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T79571AChE/Aβ-IN-2；化合物 AChE/Aβ-IN-2AChE/Aβ-IN-2
AChE/Aβ-IN-2 (compound 33) is a powerful, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 135 nM. It also functions as an NMDA receptor antagonist (GluN1-1b/GluN2B subunit combination) with an IC50 of 5.054 μM, inhibits Aβ aggregation, and exhibits favorable blood-brain barrier permeability. Additionally, it enhances cognitive and spatial memory in a rat model [1].
价 格：￥电议型 号：T79571产 地：中国大陆
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T79563Sirt1/2-IN-2；化合物 Sirt1/2-IN-2Sirt1/2-IN-2
Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin. The compound also promotes apoptosis and exhibits anti-proliferative effects on human leukemia cell lines [1].
价 格：￥电议型 号：T79563产 地：中国大陆
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T79514ABCG2-IN-2；化合物 ABCG2-IN-2ABCG2-IN-2
ABCG2-IN-2 is a potent inhibitor of ABCG2, exhibiting favorable oral pharmacokinetic profiles in mice, and is applicable for investigating tumor multidrug resistance (MDR) and erythropoietic protoporphyria (EPP) [1].
价 格：￥电议型 号：T79514产 地：中国大陆
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T79489JNK-1-IN-2；化合物 JNK-1-IN-2JNK-1-IN-2
"JNK-1-IN-2 (Compound c6) is a potent inhibitor of JNK-1 with an IC50 of 33.5 nM, and also exhibits inhibitory effects on JNK-2 and JNK-3 with IC50 values of 112.9 nM and 33.2 nM, respectively. This compound effectively inhibits the phosphorylation of c-Jun and has shown potential in reversing lung impairment, making it relevant for research into pulmonary fibrosis [1]."
价 格：￥电议型 号：T79489产 地：中国大陆
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T79487MAO A/HSP90-IN-2；化合物 MAO A/HSP90-IN-2MAO A/HSP90-IN-2
MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90. This compound not only enhances HSP70 expression but also diminishes HER2 and phospho-Akt levels, and downregulates IFN-γ-induced PD-L1 expression in GL26 cells. Demonstrating efficacy against Temozolomide-sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung cancer, and other malignancies, MAO A/HSP90-IN-2 may also impede tumor immune
价 格：￥电议型 号：T79487产 地：中国大陆
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T79485IRAK4-IN-27；化合物 IRAK4-IN-27IRAK4-IN-27
IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line, positioning it as a valuable agent for DLBCL research [1].
价 格：￥电议型 号：T79485产 地：中国大陆
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T79479MptpB-IN-2；化合物 MptpB-IN-2MptpB-IN-2
MptpB-IN-2 (compound 20), a selective inhibitor for mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), exhibits half maximal inhibitory concentrations (IC50) of 0.64 μM for MptpB, 4.06 μM for MptpA, and 4.14 μM for PTP1B. Despite its inhibition potency, MptpB-IN-2 demonstrates limited antituberculosis efficacy, with a minimum inhibitory concentration (MIC) of 64.9 μM against Mtb H37Rv [1].
价 格：￥电议型 号：T79479产 地：中国大陆
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T7945917β-HSD10-IN-2；化合物 17β-HSD10-IN-217β-HSD10-IN-2
17β-HSD10-IN-2 (compound 11), a benzothiazolylurea-based inhibitor, specifically targets 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10), avoiding mitochondrial off-targets as well as cytotoxic or neurotoxic effects. This multifunctional mitochondrial enzyme inhibitor has potential applications in Alzheimer´s disease (AD) and hormone-dependent cancer research [1].
价 格：￥电议型 号：T79459产 地：中国大陆
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T79452Tubulin/HDAC-IN-2；化合物 Tubulin/HDAC-IN-2Tubulin/HDAC-IN-2
Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor targeting Tubulin and HDAC, exhibiting IC50 values of 0.403 μM for HDAC1, 0.591 μM for HDAC2, 3.552 μM for HDAC3, and 0.459 μM for HDAC6. The compound induces G2 phase cell cycle arrest and promotes apoptosis. It effectively hampers the proliferation of both hematoma and solid tumor cells, diminishes tumor metastasis, and demonstrates tumor growth inhibition in a liver tumor allograft mouse model [1].
价 格：￥电议型 号：T79452产 地：中国大陆
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T79450Enzyme-IN-2；化合物 Enzyme-IN-2Enzyme-IN-2
Enzyme-IN-2 (compound 15) serves as a potent urease inhibitor, exhibiting anti-ureolytic activity with a K i of 2.36 ?M and an IC 50 of 0.75 ?M [1].
价 格：￥电议型 号：T79450产 地：中国大陆
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T79448IRAK4-IN-26；化合物 IRAK4-IN-26IRAK4-IN-26
IRAK4-IN-26 (Compound 21), an IRAK4 inhibitor with an IC50 of 6.2 nM, exhibits an oral bioavailability of 21%. It is utilized for the study of inflammatory and autoimmune disorders [1].
价 格：￥电议型 号：T79448产 地：中国大陆
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T79447IRAK4-IN-25；化合物 IRAK4-IN-25IRAK4-IN-25
IRAK4-IN-25 (compound 38), a potent oral IRAK4 inhibitor (IC50 = 7.3 nM) with low clearance (Cl = 12 mL/min/kg), effectively suppresses pro-inflammatory cytokine production and demonstrates favorable in vitro safety and ADME profiles. It is suitable for research on inflammatory and autoimmune disorders [1].
价 格：￥电议型 号：T79447产 地：中国大陆
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T79421DCLK1-IN-2；化合物 DCLK1-IN-2DCLK1-IN-2
DCLK1-IN-2 (Compound I-5) is a potent inhibitor of DCLK1, exhibiting an IC50 of 171.3 nM, and demonstrates significant antiproliferative effects on SW1990 cell lines with an IC50 of 0.6 μM, as well as in vivo antitumor potency [1].
价 格：￥电议型 号：T79421产 地：中国大陆
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T79420FLT3-IN-22；化合物 FLT3-IN-22FLT3-IN-22
FLT3-IN-22 (compound 22f) is a potent inhibitor of FLT3, demonstrating IC50 values of 0.941 nM for FLT3 and 0.199 nM for the FLT3/D835Y mutant. This compound displays significant antiproliferative effects against MV4-11 cells and Ba/F3 cell lines expressing mutant FLT kinase variants, such as FLT-D835Y and FLT3-F691L [1].
价 格：￥电议型 号：T79420产 地：中国大陆
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T79396T3SS-IN-2；化合物 T3SS-IN-2T3SS-IN-2
T3SS-IN-2 (Compound 2h) serves as an inhibitor of the type three secretion system (T3SS), with applications in bacterial infection research [1].
价 格：￥电议型 号：T79396产 地：中国大陆
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T79395CBP/p300-IN-21；化合物 CBP/p300-IN-21CBP/p300-IN-21
CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibits the growth of 4T1 tumors in mice [1].
价 格：￥电议型 号：T79395产 地：中国大陆
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T79393ALK/EGFR-IN-2；化合物 ALK/EGFR-IN-2ALK/EGFR-IN-2
ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells. It effectively suppresses proliferation in H1975, PC9, and Baf3-EML4-ALK cancer cell lines, demonstrating IC50s of 0.0034, 0.0065, and 0.0018 μM, respectively [1].
价 格：￥电议型 号：T79393产 地：中国大陆
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T79391FLT3-IN-21；化合物 FLT3-IN-21FLT3-IN-21
FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase. It effectively inhibits the proliferation of FLT3-ITD-positive AML cells MV-4-11, with an IC50 of 5.3 nM. In murine models, a daily dose of 10 mg/kg FLT3-IN-21 markedly inhibited tumor growth in the MV-4-11 xenograft model, achieving a tumor growth inhibition (TGI) of 92.16% [1].
价 格：￥电议型 号：T79391产 地：中国大陆
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T79389LTB4-IN-2；化合物 LTB4-IN-2LTB4-IN-2
LTB4-IN-2 (Compound 6x) is a selective inhibitor of Leukotriene B4 (LTB4), acting by specifically targeting the 5-Lipoxygenase-activating protein (FLAP) with an inhibitory concentration (IC 50) of 1.15 μM, thus serving as a potential agent for anti-inflammatory research [1].
价 格：￥电议型 号：T79389产 地：中国大陆
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T79381Galectin-3/galectin-8-IN-2；化合物 Galectin-3/galectin-8-IN-2Galectin-3/galectin-8-IN-2
Galectin-3/galectin-8-IN-2 (Compound 57) is a dual inhibitor targeting the C-terminal domains of Galectin-3 and galectin-8, exhibiting dissociation constants (Kd) of 12.8 μM and 2.06 μM, respectively. It effectively inhibits the migration of MRC-5 lung fibroblast cells and serves as a potential research tool for studying cancer and tissue fibrosis [1].
价 格：￥电议型 号：T79381产 地：中国大陆
