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T79913GRK2 Inhibitor 2；化合物 GRK2 Inhibitor 2GRK2 Inhibitor 2
GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293 cells. It is utilized in congestive heart failure (HF) research [1].
价 格：￥电议型 号：T79913产 地：中国大陆
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T79904PROTAC CDK9/CycT1 Degrader-2；化合物 PROTAC CDK9/CycT1 Degrader-2PROTAC CDK9/CycT1 Degrader-2
PROTAC CDK9/CycT1 Degrader-2 inhibits CDK9 with an IC50 of 45 nM [1].
价 格：￥电议型 号：T79904产 地：中国大陆
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T79891Androgen receptor degrader-3；化合物 Androgen receptor degrader-3Androgen receptor degrader-3
Androgen Receptor Degrader-3 (ARD-3) is a compound that inhibits androgen receptor signaling and promotes the degradation of the receptor, with potential applications in prostate cancer research [1].
价 格：￥电议型 号：T79891产 地：中国大陆
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T79856Resigratinib；化合物 ResigratinibKIN-3248；KIN-3248
Resigratinib (KIN-3248) is a FGFR tyrosine kinase inhibitor exhibiting antineoplastic activity [1].
价 格：￥电议型 号：T79856产 地：中国大陆
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T79850Irpagratinib；化合物 IrpagratinibABSK011；ABSK011
Irpagratinib (ABSK011) is an orally active fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor with specificity for FGFR4, exhibiting an IC50 of less than 10 nM. It effectively inhibits FGFR4 auto-phosphorylation and disrupts subsequent signal transduction to downstream pathways. Demonstrating high exposure in pharmacokinetic studies in mice, rats, and dogs, Irpagratinib also displays antineoplastic activity in subcutaneous xenograft tumor models [1].
价 格：￥电议型 号：T79850产 地：中国大陆
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T79831PROTAC MLKL Degrader-1；化合物 PROTAC MLKL Degrader-1PROTAC MLKL Degrader-1
PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%. The compound encompasses modified cereblon (CRBN) ligands and a lenalidomide-linker as part of its structure. It effectively inhibits cell death in a TSZ-induced model of necroptosis.
价 格：￥电议型 号：T79831产 地：中国大陆
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T79818PROTAC BRD4 Degrader-21；化合物 PROTAC BRD4 Degrader-21PROTAC BRD4 Degrader-21
PROTAC BRD4 Degrader-21 (Comp 74), a potent degrader of BRD4, has demonstrated substantial inhibition of tumor growth in mouse xenograft models, showing its potential for use in anticancer research [1].
价 格：￥电议型 号：T79818产 地：中国大陆
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T79792αvβ1 integrin-IN-2；化合物 αvβ1 integrin-IN-2αvβ1 integrin-IN-2
αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively. Additionally, this compound inhibits a range of other integrins, with IC50 values of 380 nM (ανβ3), 280 nM (ανβ5), 230 nM (ανβ6), and 87 nM (ανβ8) as determined by the SPRA assay [1].
价 格：￥电议型 号：T79792产 地：中国大陆
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T79742CARM1 degrader-2；化合物 CARM1 degrader-2CARM1 degrader-2
PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated argininemethyltransferase (CARM1). It not only promotes the degradation of CARM1 but also prevents the methylation of its substrates, including poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, which consequently inhibits breast cancer cell migration [1].
价 格：￥电议型 号：T79742产 地：中国大陆
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T79741CARM1 degrader-1；化合物 CARM1 degrader-1CARM1 degrader-1
PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1). This compound facilitates the degradation of CARM1 via the VHL-proteasome pathway. By degrading CARM1, PROTAC CARM1 degrader-1 effectively reduces the methylation of its substrates, including poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, subsequently inhibiting breast cancer cell migration [1].
价 格：￥电议型 号：T79741产 地：中国大陆
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T79505PROTAC TG2 degrader-1；化合物 PROTAC TG2 degrader-1PROTAC TG2 degrader-1
PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM. This compound effectively decreases TG2 levels in ovarian cancer cells through a proteasome-dependent pathway [1].
价 格：￥电议型 号：T79505产 地：中国大陆
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T79474GSPT1 degrader-1；化合物 GSPT1 degrader-1GSPT1 degrader-1
GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces G0/G1 phase arrest and apoptosis in cells [1].
价 格：￥电议型 号：T79474产 地：中国大陆
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T79437NAMPT degrader-3；化合物 NAMPT degrader-3NAMPT degrader-3
NAMPT Degrader-3 (compound C5) is a NAMPT degrader that functions through a VHL- and proteasome-dependent mechanism. It exhibits cytotoxic properties and inhibits the proliferation of A2780 cells [1].
价 格：￥电议型 号：T79437产 地：中国大陆
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T79425TGR5 agonist 4；化合物 TGR5 agonist 4TGR5 agonist 4
TGR5 agonist 4 (compound 19), a derivative of cholic acid, selectively activates the TGR5 receptor with an effective concentration (EC50) of 4 μM [1].
价 格：￥电议型 号：T79425产 地：中国大陆
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T79424TGR5 agonist 3；化合物 TGR5 agonist 3TGR5 agonist 3
Compound 8, a cholic acid derivative, functions as a selective TGR5 agonist and exhibits an EC50 value of 5 μM [1].
价 格：￥电议型 号：T79424产 地：中国大陆
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T79383ER degrader 7；化合物 ER degrader 7ER degrader 7
ER degrader 7 (Compound 35t) is a selective degrader of both ERα and ERβ, and possesses activity as a tubulin polymerization inhibitor. It exhibits potent cell viability inhibition, with IC50 values of 0.06 μM for MCF-7, 2.56 μM for T47D, 15.84 μM for MCF-10A, 1.59 μM for LCC2, 1.67 μM for T47D D538G, and 1.37 μM for T47D Y537S cells. Additionally, ER degrader 7 demonstrates efficacy in suppressing breast cancer tumor growth [1].
价 格：￥电议型 号：T79383产 地：中国大陆
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T79382ER degrader 6；化合物 ER degrader 6ER degrader 6
ER degrader 6 (compound 35s) is a potent selective estrogen receptor modulator (SERM) with the capacity to degrade Estrogen Receptor (ER)α. It disrupts the microtubule network, inhibiting tubulin polymerization, and effectively suppresses tumor growth with minimal toxicity [1].
价 格：￥电议型 号：T79382产 地：中国大陆
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T79323PROTAC Hsp90α degrader 1；化合物 PROTAC Hsp90α degrader 1PROTAC Hsp90α degrader 1
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research. It demonstrates inhibitory effects on the proliferation of breast cancer cell lines, MDA-MB-231, MDA-MB-468, MCF-7, and MX-1, with respective IC50 values of 51.48 μM, 16.46 μM, 8.93 μM, and 11.95 μM [1].
价 格：￥电议型 号：T79323产 地：中国大陆
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T79315PROTAC TG2 degrader-2；化合物 PROTAC TG2 degrader-2PROTAC TG2 degrader-2
PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM. It inhibits cell migration and reduces TG2 levels in ovarian cancer cells, making it a valuable tool for ovarian cancer research [1].
价 格：￥电议型 号：T79315产 地：中国大陆
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T79292PROTAC BTK Degrader-5；化合物 PROTAC BTK Degrader-5PROTAC BTK Degrader-5
PROTAC BTK Degraders-5 (Compound 3e) is a selective Bruton´s tyrosine kinase (BTK) degrader with a DC50 of 7.0 nM in JeKo-1 cells, demonstrating specificity by not affecting CRBN neosubstrates. It also exhibits antiproliferative effects on various lymphoma cell lines, underscoring its potential application in chronic lymphoid malignancies research.
价 格：￥电议型 号：T79292产 地：中国大陆
