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  • T6148CX-6258 HClCX-6258 HCl,Pim-Kinase Inhibitor X,

    CX-6258 HCl is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).

    价 格：￥电议型 号：T6148产 地：美洲

  • T6149YH239-EEYH239-EE

    YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

    价 格：￥电议型 号：T6149产 地：美洲

  • T61499AAK1-IN-4；化合物 AAK1-IN-4AAK1-IN-4

    AAK1-IN-4 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), capable of efficiently penetrating the central nervous system and exhibiting oral bioactivity. It has demonstrated a high degree of selectivity with an AAK1 inhibitory concentration (IC50) of 4.6 nM, a Filt dissociation constant (Ki) of 0.9 nM, and a cellular IC50 of 8.6 nM. AAK1-IN-4 holds promise as a valuable tool in the investigation of neuropathic pain [1].

    价 格：￥电议型 号：T61499产 地：中国大陆

  • T61498Sulfisoxazole diethanolamine；化合物 Sulfisoxazole diethanolamineSulfisoxazole diethanolamine

    Sulfisoxazole diethanolamine, also known as Sulfafurazole diethanolamine, is a sulfonamide antibacterial compound with an oxazole substituent. It acts as an endothelin receptor antagonist, specifically targeting endothelin receptor A with an IC50 value of 0.60 μM and endothelin receptor B with an IC50 value of 22 μM. Additionally, Sulfisoxazole diethanolamine has been found to inhibit the release of breast cancer exosomes by specifically targeting endothelin receptor A [1] [2].

    价 格：￥电议型 号：T61498产 地：中国大陆

  • T61496NPR-C activator 1；化合物 NPR-C activator 1NPR-C activator 1

    NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C), a receptor involved in the regulation of vascular homeostasis. It acts as a potent agonist (EC50 ~ 1 μM) of C-type natriuretic peptide (CNP), showing promising in vivo pharmacokinetic properties [1].

    价 格：￥电议型 号：T61496产 地：中国大陆

  • T61495Medroxalol；化合物 MedroxalolMedroxalol

    Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist that effectively blocks both α- and β-adrenergic receptors, effectively producing antihypertensive and vasodilating effects [1].

    价 格：￥电议型 号：T61495产 地：中国大陆

  • T61494JAK-IN-21；JAK抑制剂21JAK-IN-21

    JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.

    价 格：￥电议型 号：T61494产 地：中国大陆

  • T61493Olanexidine；化合物 OlanexidineOlanexidine

    Olanexidine is a broad-spectrum antibacterial agent and antiseptic, effective against both Gram-positive and Gram-negative bacteria. It is commonly utilized in the research of infection and inflammation [1] [2] [3].

    价 格：￥电议型 号：T61493产 地：中国大陆

  • T61492Idoxuridine hydrate；化合物 Idoxuridine hydrateIdoxuridine hydrate

    Idoxuridine hydrate (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is a competitive inhibitor of phosphorylases. As an iodinated thymidine analogue, it effectively inhibits DNA polymerase and hinders viral replication, making it useful in the treatment of viral eye infections such as herpes simplex keratitis. Against feline herpesvirus, Idoxuridine has been found to have an IC50 value of 4.3 μM [1].

    价 格：￥电议型 号：T61492产 地：中国大陆

  • T61491(R)-ND-336；化合物 (R)-ND-336(R)-ND-336

    (R)-ND-336 is a highly potent and selective MMP-9 inhibitor, displaying a K i value of 19 nM. It also exhibits inhibitory activity against MMP-2 (K i = 127 nM) and MMP-14 (K i =119 nM). With its significant potential, (R)-ND-336 is being investigated in the field of diabetic foot ulcers (DFUs) research [1].

    价 格：￥电议型 号：T61491产 地：中国大陆

  • T61490P2X receptor-1；化合物 P2X receptor-1P2X receptor-1

    P2X receptor-1 is a potential inhibitor of P2X receptor for the treatment of pain and inflammation.

    价 格：￥电议型 号：T61490产 地：中国大陆

  • T6149YH239-EE；化合物YH239-EEYH239-EE

    YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

    价 格：￥电议型 号：T6149产 地：中国大陆

  • T61489VEGFR-2/DHFR-IN-1；化合物 VEGFR-2/DHFR-IN-1VEGFR-2/DHFR-IN-1

    VEGFR-2/DHFR-IN-1 (compound 8b) is a chemical inhibitor targeting VEGFR-2 and DHFR, exhibiting IC50 values of 0.384 μM and 7.881 μM, respectively. It demonstrates effective antibacterial properties against a range of pathogens including Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA, and MRSA, with MIC values ranging from 8 to 16 μg/mL. Additionally, this compound shows potent cytotoxic effects against various cancer cell lines such as C26, HepG2, and MCF7, with IC50 values

    价 格：￥电议型 号：T61489产 地：中国大陆

  • T61487APE1-IN-1；APE1抑制剂1APE1-IN-1

    APE1-IN-1 is a potent purine/pyrimidine endonuclease 1 (APE1)-free inhibitor that crosses the blood-brain barrier with potential antitumor activity and potentiates the cytotoxicity of the alkylating agent, methyl methanesulfonate, on cancer cells.

    价 格：￥电议型 号：T61487产 地：中国大陆

  • T61486DHFR-IN-4；DHFR抑制剂4DHFR-IN-4

    DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer.

    价 格：￥电议型 号：T61486产 地：中国大陆

  • T61485S07-2010；化合物 S07-2010S07-2010

    S07-2010 is a potent pan-AKR1C inhibitor, effectively inhibiting AKR1C3, AKR1C4, AKR1C1, and AKR1C2 with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM, respectively. This compound induces apoptosis in A549/DDP cells and enhances the cytotoxicity of chemotherapeutic agents in drug-resistant cells, making it a viable option for combating drug resistance. Furthermore, S07-2010 significantly inhibits the proliferation of drug-resistant cells [1].

    价 格：￥电议型 号：T61485产 地：中国大陆

  • T61484LasR-IN-1；化合物 LasR-IN-1LasR-IN-1

    LasR-IN-1 (compound 9g) is a highly effective inhibitor of LasR, exhibiting strong potency against E. coli. It also demonstrates significant anti-bacterial properties, displaying a minimum inhibitory concentration (MIC) of 28.13 μM against P. aeruginosa [1].

    价 格：￥电议型 号：T61484产 地：中国大陆

  • T61483GLP-1R modulator C5；化合物GLP-1R modulator C5GLP-1R modulator C5

    GLP-1R modulator C5 is a small molecule GLP-1R orthosteric modulator that enhances GLP-1 binding to GLP-1R via transmembrane sites and can be used in the study of type II diabetes.

    价 格：￥电议型 号：T61483产 地：中国大陆

  • T61482Tubulin polymerization-IN-13；化合物 Tubulin polymerization-IN-13Tubulin polymerization-IN-13

    Tubulin polymerization-IN-13 (Compound 4f) is a potent inhibitor of tubulin polymerization, with an IC50 value of 0.37 μM. It displays significant anti-proliferative effects against cancer cells, inducing apoptosis and exhibiting potential antivascular activity [1].

    价 格：￥电议型 号：T61482产 地：中国大陆

  • T61481TP0480066；化合物 TP0480066TP0480066

    TP0480066, a selective topoisomerase II inhibitor, demonstrates excellent inhibitory activity against DNA gyrase (IC50 = 1.10 nM) and topo IV (IC50 = 62.89 nM). This compound exhibits potent efficacy against multiple bacterial species, including drug-resistant strains. Moreover, TP0480066 displays significant inhibitory activity against N. gonorrhoeae, making it suitable for research on gonorrhea [1] [2].

    价 格：￥电议型 号：T61481产 地：中国大陆

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