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  • T61425Tyrosinase-IN-5；化合物 Tyrosinase-IN-5Tyrosinase-IN-5

    Tyrosinase-IN-5 (compound 16c) is a highly effective inhibitor of tyrosinase, exhibiting an IC50 value of 0.02 μM. This compound efficiently suppresses melanogenesis while posing minimal toxicity to cells [1].

    价 格：￥电议型 号：T61425产 地：中国大陆

  • T61424OD36 hydrochloride；OD36盐酸盐OD 36 hydrochloride|||OD-36 hydrochloride；OD 36 hydrochloride|||OD-36 hydr

    OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of the ALK2 kinase and effectively antagonizes mutant ALK2 signaling and osteogenic differentiation.OD36 hydrochloride targets ALK2. OD36 hydrochloride targets ALK2 with a KD of 37 nM.

    价 格：￥电议型 号：T61424产 地：中国大陆

  • T61423Transthyretin-IN-1；化合物 Transthyretin-IN-1Transthyretin-IN-1

    Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].

    价 格：￥电议型 号：T61423产 地：中国大陆

  • T61422DPP-4-IN-1；化合物 DPP-4-IN-1DPP-4-IN-1

    DPP-4-IN-1 (compound d1) is a highly potent inhibitor of DPP-4 (dipeptidyl peptidase 4) with an IC 50 of 49 nM, making it suitable for diabetes research [1]. It shares structural similarities to Alogliptin and can be effectively utilized for studying diabetes-related mechanisms.

    价 格：￥电议型 号：T61422产 地：中国大陆

  • T61421LUF7244；化合物 LUF7244LUF7244

    LUF7244, a selective allosteric modulator of K v 11.1 channels, effectively suppresses early afterdepolarizations and holds potential for anti-arrhythmia research [1].

    价 格：￥电议型 号：T61421产 地：中国大陆

  • T61420CXCR4 antagonist 6；化合物 CXCR4 antagonist 6CXCR4 antagonist 6

    CXCR4 antagonist 6 (compound 46) is a highly potent inhibitor of CXCR4 with an IC50 value of 79 nM. It effectively inhibits the cytosolic calcium flux induced by CXCL12, achieving an IC50 of 0.25 nM. Moreover, CXCR4 antagonist 6 demonstrates significant mitigation of cell migration mediated by the CXCL12/CXCR4 interaction. Notably, this compound exhibits remarkable efficacy in a mouse model of cancer metastasis [1].

    价 格：￥电议型 号：T61420产 地：中国大陆

  • T6142PD128907 HCl；化合物PD128907盐酸盐PD128907 HCl

    PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.

    价 格：￥电议型 号：T6142产 地：中国大陆

  • T61419CXCR4 antagonist 5；化合物 CXCR4 antagonist 5CXCR4 antagonist 5

    CXCR4 antagonist 5 (compound 23), a potent CXCR4 antagonist, exhibits high inhibition efficacy against CXCR4 with an IC50 value of 8.8 nM. It effectively suppresses CXCL12-induced cytosolic calcium increase (IC50 = 0.02 nM) and hinders CXCR4/CXCL12-mediated chemotaxis. Moreover, Compound 23 demonstrates favorable physicochemical properties and in vitro safety profiles, exhibiting only marginal to moderate inhibition of CYP isozymes and hERG [1].

    价 格：￥电议型 号：T61419产 地：中国大陆

  • T61418BuChE-IN-6；化合物 BuChE-IN-6BuChE-IN-6

    BuChE-IN-6 (compound 1b) is a highly effective and specific inhibitor of BuChE (butyrylcholinesterase), demonstrating an IC50 value of 0.46 μM for eqBuChE and 0.51 μM for hBuChE. Furthermore, BuChE-IN-6 has the additional capability of inhibiting the self-aggregation of Aβ 42 [1].

    价 格：￥电议型 号：T61418产 地：中国大陆

  • T61417PPARγ agonist 7；化合物 PPARγ agonist 7PPARγ agonist 7

    PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It specifically stimulates adiponectin production in human bone marrow mesenchymal stem cells (hBM-MSCs), making it an innovative full agonist of PPARγ with an EC 50 value of 4.34 μM [1].

    价 格：￥电议型 号：T61417产 地：中国大陆

  • T61416Antileishmanial agent-9；化合物 Antileishmanial agent-9Antileishmanial agent-9

    Antileishmanial agent-9 (compound 16c) exhibits potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 4.01 μM. In addition, this compound demonstrates relatively low cytotoxicity in L-6 cells, with an IC50 value of 40.1 μM [1].

    价 格：￥电议型 号：T61416产 地：中国大陆

  • T61415FLT3/ITD-IN-1；化合物 FLT3/ITD-IN-1FLT3/ITD-IN-1

    FLT3/ITD-IN-1 (Compound 1) is a highly potent inhibitor of FLT3 internal tandem duplications (FLT3-ITD). It exhibits remarkable inhibitory effects against FLT3 and FLT3-ITD, with impressive IC50 values of 38.2 nM and 144.1 nM, respectively. Moreover, FLT3/ITD-IN-1 shows exceptional antiproliferative activities against several acute myeloid leukemia cell lines [1].

    价 格：￥电议型 号：T61415产 地：中国大陆

  • T61414DPP-4 inhibitor 3；化合物 DPP-4 inhibitor 3DPP-4 inhibitor 3

    Compound 5a, also known as DPP-4 inhibitor 3, is a powerful dipeptidyl peptidase IV (DPP-IV) inhibitor, demonstrating an IC50 value of 0.75 nM. It exhibits outstanding antioxidant and insulinotropic activity [1].

    价 格：￥电议型 号：T61414产 地：中国大陆

  • T61413Gü1303；化合物 Gü1303Gü1303

    Gü1303 is a highly potent and reversible inhibitor of Cathepsin K (CatK), with a Ki value of 0.91 nM for mature CatK (mCatK). This compound effectively suppresses the autocatalytic activation of the CatK zymogen [1].

    价 格：￥电议型 号：T61413产 地：中国大陆

  • T61412Anticancer agent 47；化合物 Anticancer agent 47Anticancer agent 47

    Anticancer agent 47 (compound 4j) exhibits potent anticancer properties, demonstrating antiproliferative activities and inducing apoptosis as well as cell cycle arrest at G0/G1 phase. Moreover, Anticancer agent 47 has exhibited significant in vivo antitumor activities [1].

    价 格：￥电议型 号：T61412产 地：中国大陆

  • T61411InhA-IN-4；InhA抑制剂4InhA-IN-4

    InhA-IN-4 (TU14) is a potent Mycobacterium tuberculosis InhA (enoyl ACP reductase) inhibitor with potential anticancer and antiproliferative activities for the study of Mycobacterium tuberculosis infections.

    价 格：￥电议型 号：T61411产 地：中国大陆

  • T61410FAK-IN-8；化合物 FAK-IN-8FAK-IN-8

    FAK-IN-8 (compound 5h), a FAK inhibitor with an IC50 of 5.32 μM, exhibits potent anti-proliferative activity, making it suitable for use in cancer research [1].

    价 格：￥电议型 号：T61410产 地：中国大陆

  • T6141IMD-0354；化合物IMD 0354IKK2 Inhibitor V|||IMD 0354；IKK2 Inhibitor V|||IMD 0354

    IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.

    价 格：￥电议型 号：T6141产 地：中国大陆

  • T61409CXCR4 antagonist 3；化合物 CXCR4 antagonist 3CXCR4 antagonist 3

    CXCR4 antagonist 3 (compound 12a), an effective antagonist of CXCR4, exhibits an IC50 of 11 nM. It is a congener of TIQ15, showcasing exceptional properties such as CXCR4 antagonism, CYP 2D6 inhibition, metabolic stability, and permeability. With its potential for research on the human immunodeficiency virus, CXCR4 antagonist 3 holds great promise [1].

    价 格：￥电议型 号：T61409产 地：中国大陆

  • T61408BChE-IN-2；化合物 BChE-IN-2BChE-IN-2

    BChE-IN-2 (compound 22) is a highly effective inhibitor of BChE, exhibiting a Ki value of 0.099 μM. This compound represents a promising pyrimidine and pyridine derivative for investigating Alzheimer´s disease (AD). [1]

    价 格：￥电议型 号：T61408产 地：中国大陆

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