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  • T61480NHE3-IN-3；化合物 NHE3-IN-3NHE3-IN-3

    NHE3-IN-3 (Compound 1) is a potent inhibitor of the isoform 3 of the Na+/H+ exchanger (NHE3). It exhibits pIC50 values of 6.2 and 6.6 against human and rat NHE3, respectively. Furthermore, NHE3-IN-3 showcases exceptional oral bioavailability of 98% in Sprague–Dawley rats [1].

    价 格：￥电议型 号：T61480产 地：中国大陆

  • T6148CX-6258 hydrochloride；化合物CX-6258 HClCX-6258 HCl|||Pim-Kinase Inhibitor X；CX-6258 HCl|||Pim-Kinase In

    CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).

    价 格：￥电议型 号：T6148产 地：中国大陆

  • T61479LOX-IN-3 dihydrochloride monohydrate；化合物 LOX-IN-3 dihydrochloride monohydrateLOX-IN-3 dihydrochlorid

    LOX-IN-3 dihydrochloride monohydrate (Compound 33) is a lysyl oxidase (LOX) inhibitor with oral activity. It is specifically designed for research purposes in the areas of fibrosis, cancer, and angiogenesis [1].

    价 格：￥电议型 号：T61479产 地：中国大陆

  • T61478ROS1-IN-1；化合物 ROS1-IN-1ROS1-IN-1

    ROS1-IN-1 (Compound 31) is a highly effective and specific inhibitor of the ROS1 kinase, displaying a remarkable inhibitory concentration (IC 50) of 0.097 μM [1].

    价 格：￥电议型 号：T61478产 地：中国大陆

  • T61477dCeMM2；化合物dCeMM2dCeMM2

    dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K.

    价 格：￥电议型 号：T61477产 地：中国大陆

  • T61476Thioridazine；化合物 ThioridazineThioridazine

    Thioridazine is a chemical compound characterized by its potent anti-psychotic and anti-anxiety activities. As an antagonist of the dopamine receptor D2 family proteins, it exhibits a strong inhibitory effect on the PI3K-Akt-mTOR signaling pathways, resulting in anti-angiogenic effects. It also demonstrates significant antiproliferative and apoptosis induction effects in a diverse range of cancer cells, specifically targeting cancer stem cells (CSCs) [1] [2] [3] [4].

    价 格：￥电议型 号：T61476产 地：中国大陆

  • T61475Ropivacaine mesylate；化合物 Ropivacaine mesylateRopivacaine mesylate

    Ropivacaine mesylate, a long-acting amide local anaesthetic, is used for spinal block and effectively mitigates neuropathic pain. It achieves analgesia by reversibly inhibiting sodium ion influx in nerve fibers, thus blocking impulse conduction. Additionally, Ropivacaine acts as an inhibitor of the K2P (two-pore domain potassium channel) TREK-1, exhibiting an IC50 of 402.7 μM in COS-7 cell membranes.

    价 格：￥电议型 号：T61475产 地：中国大陆

  • T61474HDAC6-IN-13；化合物 HDAC6-IN-13HDAC6-IN-13

    HDAC6-IN-13 (Compound 35m) is a potent and highly selective orally active inhibitor of HDAC6, with an IC50 of 0.019 μM. It also demonstrates inhibitory activity against HDAC1, HDAC2, and HDAC3, with IC50 values of 1.53 μM, 2.06 μM, and 1.03 μM, respectively. HDAC6-IN-13 exhibits substantial blood-brain barrier permeability and displays anti-inflammatory properties [1].

    价 格：￥电议型 号：T61474产 地：中国大陆

  • T61473FGFR2-IN-2；化合物 FGFR2-IN-2FGFR2-IN-2

    FGFR2-IN-2 is a selective FGFR2 inhibitor with an IC 50 of 29 nM.

    价 格：￥电议型 号：T61473产 地：中国大陆

  • T61472Tubulin inhibitor 18；化合物 Tubulin inhibitor 18Tubulin inhibitor 18

    Tubulin inhibitor 18 (compound 5j) is a highly potent chalcone compound that effectively inhibits tubulin. Its unique molecular structure renders Tubulin inhibitor 18 as a promising candidate for cancer research [1].

    价 格：￥电议型 号：T61472产 地：中国大陆

  • T61471Antitubercular agent-13；化合物 Antitubercular agent-13Antitubercular agent-13

    Antitubercular agent-13 (Compound 3d) is an antitubercular agent with MIC values of 0.007 μg/mL and 1.851 μg/mL against MTB H37Rv and MDR-MTB 16833, respectively. Antitubercular agent-13 shows metabolic instability [1].

    价 格：￥电议型 号：T61471产 地：中国大陆

  • T61470NMDA receptor antagonist 5；化合物 NMDA receptor antagonist 5NMDA receptor antagonist 5

    NMDA receptor antagonist 5 (Compound 10e), a potent and non-toxic NMDA receptor antagonist, exhibits brain permeability. It is of significance in studying neurological disorders [1].

    价 格：￥电议型 号：T61470产 地：中国大陆

  • T6147Nortadalafil；去甲基他达那非Demethyl Tadalafil；Demethyl Tadalafil|||去甲基他达那非

    Nortadalafil (Demethyl Tadalafil) is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio.

    价 格：￥电议型 号：T6147产 地：中国大陆

  • T61469RAD51-IN-8；化合物 RAD51-IN-8RAD51-IN-8

    RAD51-IN-8, a new RAD51 binder, is a RAD51-BRCA2 inhibitor that inhibits the RAD51 BRCA2 protein protein interaction in the micromolar range. RAD51-IN-8 also is a protein protein interaction (PPI) inhibitor. RAD51-IN-8 has inhibitory activity for H4A4 with an EC 50 value of 19 μM [1].

    价 格：￥电议型 号：T61469产 地：中国大陆

  • T61467Esomeprazole magnesium salt；化合物 Esomeprazole magnesium saltEsomeprazole magnesium salt

    Esomeprazole magnesium salt is a potent and orally active proton pump inhibitor that effectively reduces acid secretion in gastric parietal cells by inhibiting the H+, K+-ATPase. This compound has shown promise for the research and treatment of symptomatic gastroesophageal reflux disease [1][2][3].

    价 格：￥电议型 号：T61467产 地：中国大陆

  • T61466PptT-IN-3；化合物 PptT-IN-3PptT-IN-3

    PptT-IN-3 (compound 5p) is a powerful inhibitor (IC 50 = 3.5 μM) of phosphopantetheinyl phosphoryl transferase (PptT), an indispensable enzyme involved in the synthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. This compound, PptT-IN-3, holds promise for tuberculosis research [1].

    价 格：￥电议型 号：T61466产 地：中国大陆

  • T61465PPARγ agonist 3；化合物 PPARγ agonist 3PPARγ agonist 3

    PPARγ agonist 3, also known as Compound 18a, is a potent and selective agonist of PPARγ. This compound does not exhibit cytotoxicity towards both non-resistant and resistant cells. Notably, PPARγ agonist 3 demonstrates antitumor efficacy exclusively when co-administered with Imatinib [1].

    价 格：￥电议型 号：T61465产 地：中国大陆

  • T61464TRβ agonist 2；化合物 TRβ agonist 2TRβ agonist 2

    TRβ agonist 2 (Compound 1) is a highly potent agonist of TRβ. Moreover, it effectively reduces lipid accumulation in HepG2 cells and promotes lipolysis, offering comparable effects. With its promising attributes, TRβ agonist 2 emerges as a potential thyromimetics that selectively targets TRβ [1].

    价 格：￥电议型 号：T61464产 地：中国大陆

  • T61463Monoamine oxidase/Aromatase-IN-1；化合物 Monoamine oxidase/Aromatase-IN-1Monoamine oxidase/Aromatase-IN-

    Monoamine oxidase/Aromatase-IN-1 (compound 2q) is a potent dual inhibitor of monoamine oxidase (MAO) and aromatase, with IC50 values of 39 nM and 31 nM for MAO-B and aromatase, respectively. It holds significant potential for research in neurological disorders and breast cancer [1].

    价 格：￥电议型 号：T61463产 地：中国大陆

  • T61462EV-A71-IN-1；化合物 EV-A71-IN-1EV-A71-IN-1

    EV-A71-IN-1 is a potent inhibitor of the human enterovirus A71 (EV-A71) capsid protein, with an EC50 of 0.27 μM against EV-A71. Acting as a capsid binder, EV-A71-IN-1 disrupts the crucial interaction between the viral VP1 protein and the host receptor hSCARB2. It displays broad-spectrum antiviral activity against various human enteroviruses, while being non-toxic to human cells (CC50 > 56.2 μM) [1].

    价 格：￥电议型 号：T61462产 地：中国大陆

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