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  • T61461Anticancer agent 37；化合物 Anticancer agent 37Anticancer agent 37

    Anticancer agent 37 (compound 18) is a sulfonylurea derivative known for its potent anticancer activity. It efficiently inhibits the growth of HePG2 cells, displaying an IC 50 value of 17.2 μg/mL [1].

    价 格：￥电议型 号：T61461产 地：中国大陆

  • T61460Tyrosinase-IN-3；化合物 Tyrosinase-IN-3Tyrosinase-IN-3

    Tyrosinase-IN-3 (compound 54) is a powerful tyrosinase inhibitor, an enzyme involved in the key catalytic step of melanin biosynthesis and enzymatic browning. As a copper-containing metalloenzyme, tyrosinase plays a crucial role in these processes. The compound shows promise for studying skin whitening agents and food preservatives [1].

    价 格：￥电议型 号：T61460产 地：中国大陆

  • T6146Dorsomorphin dihydrochloride；化合物Dorsomorphin dihydrochlorideBML-275 2HCl|||Compound C dihydrochlorid

    Dorsomorphin dihydrochloride (BML-275 2HCl) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin dihydrochloride inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride induces autophagy, and possesses antitumor activity.

    价 格：￥电议型 号：T6146产 地：中国大陆

  • T61459Tubulin inhibitor 19；化合物 Tubulin inhibitor 19Tubulin inhibitor 19

    Tubulin inhibitor 19 (compound 9b) is a potent indole chalcone compound that exhibits strong inhibitory activity against tubulin. Its potential in cancer research makes it valuable for studying cancer diseases [1].

    价 格：￥电议型 号：T61459产 地：中国大陆

  • T61458HIF-PHD-IN-2；化合物 HIF-PHD-IN-2HIF-PHD-IN-2

    HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].

    价 格：￥电议型 号：T61458产 地：中国大陆

  • T61457SIRT5 inhibitor 4；化合物 SIRT5 inhibitor 4SIRT5 inhibitor 4

    SIRT5 inhibitor 4 (compound 11) is a highly effective and selective inhibitor of SIRT5, with IC50 values of 26.4 μM and >400 μM for SIRT5 and other SIRT subtypes, respectively [1].

    价 格：￥电议型 号：T61457产 地：中国大陆

  • T61456OXS007417；化合物 OXS007417OXS007417

    OXS007417, a chemical compound, exhibits in vitro induction of differentiation in acute myeloid leukemia cells with a half-maximal effective concentration of 48 nM (EC 50 = 48 nM). Additionally, it demonstrates significant antitumor effects in vivo.

    价 格：￥电议型 号：T61456产 地：中国大陆

  • T61455BSP16；化合物 BSP16BSP16

    BSP16 is a highly potent and orally active STING agonist, capable of selectively stimulating the interferon genes pathway. This compound, BSP16, holds great potential for cancer research [1].

    价 格：￥电议型 号：T61455产 地：中国大陆

  • T61454α-NETA；化合物 α-NETAα-NETA

    α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC 50 of 9 μM. α-NETA is a potent ALDH1A1 ( IC 50 =0.04 μM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC 50 =84 μM) and acetylcholinesterase (AChE; IC 50 =300 μM). α-NETA has anti-cancer activity [1] [2].

    价 格：￥电议型 号：T61454产 地：中国大陆

  • T61453Propantheline；化合物 PropanthelinePropantheline

    Propantheline is an orally active antagonist of muscarinic acetylcholine receptors (mAChRs), commonly employed to investigate smooth muscle dysfunction, hyperhidrosis, smooth muscle spasms or cramps in the stomach, intestines, or bladder, as well as involuntary urination [1] [2] [3].

    价 格：￥电议型 号：T61453产 地：中国大陆

  • T61451NMDAR/HDAC-IN-1；化合物 NMDAR/HDAC-IN-1NMDAR/HDAC-IN-1

    NMDAR/HDAC-IN-1 (Compound 9d) is a potent dual inhibitor of N-methyl-D-aspartate receptors (NMDARs) and histone deacetylases (HDACs). It exhibits a high affinity (Ki = 0.59 μM) for NMDARs, while demonstrating significant inhibitory effects on various HDAC isoforms, including HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC 50 values of 2.67 μM, 8.00 μM, 2.21 μM, 0.18 μM, and 0.62 μM, respectively. Moreover, NMDAR/HDAC-IN-1 efficiently crosses the blood-brain barrier [1].

    价 格：￥电议型 号：T61451产 地：中国大陆

  • T61450IM-93；化合物 IM-93IM-93

    IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 μM for cell death inhibition [1].

    价 格：￥电议型 号：T61450产 地：中国大陆

  • T6145ZM39923 hydrochloride化合物ZM 39923 HClJAK3 Inhibitor IV|||ZM 39923 HCl

    ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.

    价 格：￥电议型 号：T6145产 地：中国大陆

  • T61449HPK1-IN-18；化合物 HPK1-IN-18HPK1-IN-18

    HPK1-IN-18 is a highly effective and specific HPK1 inhibitor. HPK1, a MAP kinase kinase kinase kinases (MAP4K) member, was initially isolated from hematopoietic progenitor cells. This compound, known as HPK1-IN-18, is valuable for investigating, preventing, or managing diseases or conditions linked to HPK1 activity, such as cancer[1].

    价 格：￥电议型 号：T61449产 地：中国大陆

  • T61448AZA1；化合物AZA1Rac1/Cdc42-IN-1；Rac1/Cdc42-IN-1

    AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.

    价 格：￥电议型 号：T61448产 地：中国大陆

  • T61447CXCR2 antagonist 4；化合物 CXCR2 antagonist 4CXCR2 antagonist 4

    CXCR2 antagonist 4 (compound 7) is a highly potent antagonist that inhibits CXCR2 with an IC50 value of 0.13 μM. It also effectively inhibits the cytosolic calcium increase induced by CXCL8, with an IC50 value of 27 μM. CXCR2 antagonist 4 shows promising potential for anticancer research [1].

    价 格：￥电议型 号：T61447产 地：中国大陆

  • T61446BioA-IN-13；化合物 BioA-IN-13BioA-IN-13

    BioA-IN-13 is a highly effective inhibitor of the Mycobacterium tuberculosis BioA enzyme, displaying potent cell permeability and whole-cell activity [1].

    价 格：￥电议型 号：T61446产 地：中国大陆

  • T61445Tenatoprazole sodium；化合物 Tenatoprazole sodiumTenatoprazole sodium

    Tenatoprazole sodium (TU-199 sodium) is a potent proton pump inhibitor that effectively suppresses the activity of hog gastric H+/K+-ATPase, a vital enzymatic pump involved in acid secretion. It achieves this inhibition at an impressive IC50 value of 6.2 μM.

    价 格：￥电议型 号：T61445产 地：中国大陆

  • T61444Nonsteroidal aromatase inhibitor 1；化合物 Nonsteroidal aromatase inhibitor 1Nonsteroidal aromatase inhi

    Nonsteroidal aromatase inhibitor 1 (Compound 13h) effectively inhibits the enzyme CYP19A1 with an IC50 value of 0.09 nM. Due to its potent inhibitory activity, Nonsteroidal aromatase inhibitor 1 holds promise for research in the field of breast cancer [1].

    价 格：￥电议型 号：T61444产 地：中国大陆

  • T61443Trk-IN-7；化合物 Trk-IN-7Trk-IN-7

    Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (IC50 <15 nM), as well as ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC50 = 5-50 nM) [1].

    价 格：￥电议型 号：T61443产 地：中国大陆

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