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T61442HIF-1/2α-IN-1；化合物 HIF-1/2α-IN-1HIF-1/2α-IN-1
HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrease HIF-1α levels. This compound is particularly valuable for research on clear cell renal cell carcinoma (ccRCC) [1].
价 格：￥电议型 号：T61442产 地：中国大陆
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T61441NSC381467；化合物 NSC381467NSC381467
NSC381467, a potent and orally active inhibitor of the EGFR tyrosine kinase (EGFR-TK), exhibits robust antiproliferative activity, making it a promising candidate for cancer research [1].
价 格：￥电议型 号：T61441产 地：中国大陆
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T61440TOPK-p38/JNK-IN-1；化合物 TOPK-p38/JNK-IN-1TOPK-p38/JNK-IN-1
TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NO production. It demonstrates anti-inflammatory properties by inhibiting downstream phosphorylation of related proteins and preventing the degradation of TOPK [1].
价 格：￥电议型 号：T61440产 地：中国大陆
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T6144KB-R7943 mesylate；化合物KB-R7943KB-R7943；KB-R7943
KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM.
价 格：￥电议型 号：T6144产 地：中国大陆
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T6143LPI-103 Hydrochloride；化合物 T6143LPI-103 Hydrochloride
PI-103 Hydrochloride is a potent dual inhibitor of PI3K and mTOR, demonstrating inhibitory IC50 values of 8 nM for p110α, 88 nM for p110β, 48 nM for p110δ, 150 nM for p110γ, 20 nM for mTORC1, and 83 nM for mTORC2, respectively. Additionally, it inhibits DNA-PK with an IC50 of 2 nM and induces autophagy [1] [2] [3] [4].
价 格：￥电议型 号：T6143L产 地：中国大陆
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T61439DSS30；化合物DSS30DSS30
DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).DSS30 can be used for the prevention and treatment of neurodegenerative diseases such as Alzheimer´s disease.
价 格：￥电议型 号：T61439产 地：中国大陆
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T61438Propiverine；化合物 PropiverinePropiverine
Propiverine is a potent antimuscarinic agent that effectively inhibits cellular calcium influx, leading to the reduction of muscle spasm. It exhibits neurotropic and musculotropic effects specifically on the smooth muscles of the urinary bladder. Propiverine proves valuable in research concerning overactive bladder (OAB) [1] [2].
价 格：￥电议型 号：T61438产 地：中国大陆
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T61437HPK1-IN-26；化合物 HPK1-IN-26HPK1-IN-26
HPK1-IN-26, a novel compound, is a potent inhibitor of both HPK1 and GLK. This small molecule exhibits promise in aiding the study of animal pathogen infection [1].
价 格：￥电议型 号：T61437产 地：中国大陆
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T61436Cdc7-IN-18；化合物 Cdc7-IN-18Cdc7-IN-18
Cdc7-IN-18 (compound 1-2) is a highly effective inhibitor of the CDC7 enzyme. It has an IC 50 value of 1.29 nM for the Cdc7/DBF4 enzyme. In addition, this compound exhibits strong antiproliferative activities, with an IC 50 value of 53.62 nM in COLO205 cells [1].
价 格：￥电议型 号：T61436产 地：中国大陆
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T61435(S)-Cdc7-IN-18；化合物 (S)-Cdc7-IN-18(S)-Cdc7-IN-18
(S)-Cdc7-IN-18, a potent CDC7 inhibitor, effectively impedes the overactivation of MCM2, a crucial tumor cell marker, induced by huCdc7 overexpression. Consequently, it inhibits the aberrant proliferation of tumor cells. This compound, exhibits promise for cancer disease research [1].
价 格：￥电议型 号：T61435产 地：中国大陆
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T61434Mirogabalin besylate；化合物 Mirogabalin besylateMirogabalin besylate
Mirogabalin besylate is a potent and orally active ligand that selectively targets the α2δ subunit of voltage-gated calcium channels. It displays high affinity (K d ) values, namely 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM, for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.
价 格：￥电议型 号：T61434产 地：中国大陆
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T61433HDAC1-IN-5；化合物 HDAC1-IN-5HDAC1-IN-5
HDAC1-IN-5, a potent inhibitor of HDAC1 with an IC50 value of 15 nM, also exhibits inhibitory activity towards HDAC6 with an IC50 value of 20 nM. In cancer cells, HDAC1-IN-5 enhances the acetylation of both histone H3 and α-tubulin, leading to the activation of caspase 3 and induction of apoptosis. Additionally, HDAC1-IN-5 binds with DNA, causing chromatin damage. Furthermore, it demonstrated strong inhibitory activity against tumor growth in xenograft mice. [1]
价 格：￥电议型 号：T61433产 地：中国大陆
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T61432ATR-IN-16；化合物 ATR-IN-16ATR-IN-16
ATR-IN-16 (compound 46) is a highly effective ATR kinase inhibitor, exhibiting considerable anticancer activity in LoVo cells, as demonstrated by its IC 50 value of 410 nM [1].
价 格：￥电议型 号：T61432产 地：中国大陆
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T61431Topoisomerase IIα-IN-4；化合物 Topoisomerase IIα-IN-4Topoisomerase IIα-IN-4
Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, specifically inhibiting TopoIIα with an IC50 value of 3.8 μM and TopoIIβ with an IC50 value of 10.1 μM. It demonstrates significant efficacy in inducing apoptosis and arresting the cell cycle in HepG2 cells. Moreover, Topoisomerase IIα-IN-4 exhibits robust antitumor effects against various human cancer cell lines, making it a valuable compound for cancer research [1].
价 格：￥电议型 号：T61431产 地：中国大陆
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T61430S-2E；化合物 S-2ES-2E
S-2E is a compound that functions as an orally active, noncompetitive inhibitor of both HMG-CoA reductase and acetyl-CoA carboxylase. It exhibits an anti-hyperlipidemic action, making it suitable for studying conditions such as familial hypercholesterolemia and mixed hyperlipidemia [1] [2].
价 格：￥电议型 号：T61430产 地：中国大陆
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T6143PI-103；化合物PI103PI103|||PI 103；PI103|||PI 103
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).
价 格：￥电议型 号：T6143产 地：中国大陆
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T61429HDAC-IN-33；化合物 HDAC-IN-33HDAC-IN-33
HDAC-IN-33 is a highly potent HDAC inhibitor, effectively inhibiting HDAC1, HDAC2, and HDAC6 with IC50 values of 24, 46, and 47 nM, respectively. This compound demonstrates significant antiproliferation activity against tumor cells and exhibits remarkable in vivo antitumor efficacy. Additionally, HDAC-IN-33 initiates the activation of antitumor immunity [1].
价 格：￥电议型 号：T61429产 地：中国大陆
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T614284-PQBH；化合物4-PQBH4-PQBH
4-PQBH is a potent Nur77-binding agent with antitumour activity.4-PQBH inhibits xenograft tumours through Nur77-mediated endoplasmic stress and autophagy by broadly inducing cysteoaspartase-independent cytoplasmic vacuolisation and parapetaloid ptosis.4-PQBH is used in the study of hepatocellular carcinoma.4-PQBH is a potent Nur77-binding agent with antitumour activity.
价 格：￥电议型 号：T61428产 地：中国大陆
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T61427Lamivudine salicylate；化合物 Lamivudine salicylateLamivudine salicylate
Lamivudine (BCH-189) salicylate is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that effectively inhibits the reverse transcriptase activity of both HIV 1/2 and hepatitis B virus. Moreover, it demonstrates the ability to penetrate the central nervous system [1] [2].
价 格：￥电议型 号：T61427产 地：中国大陆
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T61426NOS-IN-2；化合物 NOS-IN-2NOS-IN-2
NOS-IN-2 (Compound 4i), an imidamide-derived NOS inhibitor, exhibits high potency and selectivity, specifically inhibiting iNOS with an IC50 of 20 μM while sparing eNOS. Demonstrating minimal toxicity, it is suitable for research on inflammatory disorders [1].
价 格：￥电议型 号：T61426产 地：中国大陆
