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T69836Paltusotine HCl；化合物 Paltusotine HClPaltusotine HCl
Paltusotine, also known as CRN00808, is a somatostatin receptor agonist.
价 格：￥电议型 号：T69836产 地：中国大陆
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T69825Dexetimide HCl；化合物 Dexetimide HClDexetimide HCl
Dexetimide HCl is a muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
价 格：￥电议型 号：T69825产 地：中国大陆
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T69810N-2733 HCl；化合物 N-2733 HClN-2733 HCl
N-2733 HCl is a nuclear factor (NF)-kappaB activation inhibitor.
价 格：￥电议型 号：T69810产 地：中国大陆
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T697984-Me-PDTic HCl；化合物 4-Me-PDTic HCl4-Me-PDTic HCl
4-Me-PDTic is a potent and selective Kappa Opioid Receptor Antagonist. 4-Me-PDTic had a Ke = 0.37 nM in a [35S]GTPγS binding assay and was 645- and >8100-fold selective for the κ relative to the μ and δ opioid receptors, respectively. Calculated logBB and CNS (central nervous system) multiparameter optimization (MPO) and low molecular weight values all predict that 4-Me-PDTic will penetrate the brain and pharmacokinetic studies in rats shows that 4-Me-PDTic does indeed penetrate the brain.
价 格：￥电议型 号：T69798产 地：中国大陆
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T69784GSK3527497 HCl；化合物 GSK3527497 HClGSK3527497 HCl
GSK3527497 is a potent and selective inhibitor of Transient Receptor Potential Vanilloid?4 (TRPV4) with IC50 = 12 nM) for the treatment of heart failure and respiratory diseases. GSK3527497 is a preclinical candidate suitable for oral and iv administration that is projected to inhibit TRPV4 effectively in patients from a low daily clinical dose.
价 格：￥电议型 号：T69784产 地：中国大陆
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T69766Gusacitinib HCl；化合物 Gusacitinib HClGusacitinib HCl
Gusacitinib, also known as ASN-002 and EN-3351, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively. When profiled in a panel of 178 cell lines, ASN002 showed strong anti-proliferative activity in many lymphoid/leukemia cell lines, including SU-DHL-6, SU-DHL-4, OCI-LY10, H929 and
价 格：￥电议型 号：T69766产 地：中国大陆
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T69741DWN-12088 HCl；化合物 DWN-12088 HClDWN-12088 HCl
DWN-12088 HCl is the salt form of DWN-12088 Free Base, an orally administered small molecule prolyl-tRNA synthetase (PRS) inhibitor
价 格：￥电议型 号：T69741产 地：中国大陆
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T69712Icapamespib HCl；化合物 Icapamespib HClIcapamespib HCl
Icapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans.
价 格：￥电议型 号：T69712产 地：中国大陆
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T69682AEW541 HCl；化合物 AEW541 HClAEW541 HCl
AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder sc
价 格：￥电议型 号：T69682产 地：中国大陆
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T69669Camsirubicin HCl；化合物 Camsirubicin HClCamsirubicin HCl
Camsirubicin, also known as GPX-150, MNPR-201, and CNDO1011, is a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis.
价 格：￥电议型 号：T69669产 地：中国大陆
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T69667IAG-10 HCl；化合物 IAG-10 HClIAG-10 HCl
IAG-10 is a Novel potent and selective inhibitor of human DNA polymerase kappa (hpol κ).
价 格：￥电议型 号：T69667产 地：中国大陆
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T69664Umibecestat HCl；化合物 Umibecestat HClUmibecestat HCl
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer´s disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP‐transgenic mice
价 格：￥电议型 号：T69664产 地：中国大陆
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T69657GS-441524 HCl；化合物 GS-441524 HClGS-441524 HCl
GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM.. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. GS-441524 was non-toxic in feline cells at concentrations
价 格：￥电议型 号：T69657产 地：中国大陆
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T69648Inupadenant HCl；化合物 Inupadenant HClInupadenant HCl
Inupadenant, also known as EOS-850, is a highly selective small molecule antagonist of the adenosine A2a receptor, in the adenosine triphosphate adenosine pathway, a key driver of immunosuppression in the tumor microenvironment across a broad range of tumors.
价 格：￥电议型 号：T69648产 地：中国大陆
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T69641EP-7041 HCl；化合物 EP-7041 HClEP-7041 HCl
EP-7041 is a novel, potent, and selective Factor XIa inhibitor.
价 格：￥电议型 号：T69641产 地：中国大陆
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T69627Dapivirine HCl；化合物 Dapivirine HClDapivirine HCl
Dapivirine HCl is the salt form of Dapivirine, also known as TMC120, a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM. The HIV-1 replication inhibitor dapivirine (DPV) is one of the most promising drug candidates being used in topical microbicide products for prevention of HIV-1 sexual transmission.
价 格：￥电议型 号：T69627产 地：中国大陆
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T69621BIIE-0246 HCl；化合物 BIIE-0246 HClBIIE-0246 HCl
BIIE-0246 is a potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y2 receptor. BIIE-0246 displays > 650-fold selectivity over Y1, Y4 and Y5 receptors.
价 格：￥电议型 号：T69621产 地：中国大陆
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T6961PX-478；化合物PX-478 2HClPX-478 2HCl；PX-478 2HCl
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 diabetes mellitus research.
价 格：￥电议型 号：T6961产 地：中国大陆
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T6960LPU-H71 HCl；PU-H71盐酸盐PU-H71 HCl(873436-91-0 Free base)|||Zelavespib HCl；PU-H71 HCl(873436-91-0 Free b
PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of malignancy. PU-H71 HCL has an inhibitory effect on the protein expression levels of Rad51 and Ku70, which may be associated with the double chain break repair in the homologous recombination pathway and non-homologous end-joining pathway.
价 格：￥电议型 号：T6960L产 地：中国大陆
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T69608TG11-77 HCl；化合物 TG11-77 HClTG11-77 HCl
TG11-77 HCl is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 HCl has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 HCl are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties.
价 格：￥电议型 号：T69608产 地：中国大陆
