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T62393ALK5-IN-25;化合物 ALK5-IN-25ALK5-IN-25
ALK5-IN-25 (compound EX-02) is a potent inhibitor of ALK-5 (IC50<10 nM) and also inhibits ALK-2. ALK5-IN-25 can be used in cancer research.
价 格:¥电议型 号:T62393产 地:中国大陆
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T62392PI3K-IN-34;化合物 PI3K-IN-34PI3K-IN-34
PI3K-IN-34 (Compound 6g) is a highly selective inhibitor of PI3K that acts on PI3K-α (IC50: 11.73 μM), PI3K-β (IC50: 6.09 μM) and PI3K-δ (IC50: 11.18 μM). PI3K-IN-34 can be used to study leukaemia.
价 格:¥电议型 号:T62392产 地:中国大陆
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T62391FGFR-IN-6;化合物 FGFR-IN-6FGFR-IN-6
FGFR-IN-6 (Compound 5) is an FGFR inhibitor.
价 格:¥电议型 号:T62391产 地:中国大陆
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T62390CSF1R-IN-8;化合物 CSF1R-IN-8CSF1R-IN-8
CSF1R-IN-8 (Compound 22) is a CSF-1R inhibitor (IC50: 0.012 μM).
价 格:¥电议型 号:T62390产 地:中国大陆
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T6238914α-Demethylase/DNA Gyrase-IN-2;化合物 14α-Demethylase/DNA Gyrase-IN-214α-Demethylase/DNA Gyrase-IN-2
14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.
价 格:¥电议型 号:T62389产 地:中国大陆
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T62388RUSKI-201 dihydrochloride;化合物 RUSKI-201 dihydrochlorideRUSKI-201 dihydrochloride
RUSKI-201 dihydrochloride is a potent and specific inhibitor of Hedgehog acyltransferase (Hhat) (IC50: 0.20 μM). RUSKI-201 dihydrochloride blocks Hh signalling in Shh overexpressing cells and has an inhibitory effect on Hh palmitoylation. RUSKI-201 dihydrochloride is a promising Hhat chemical probe that can be used to study Hhat catalytic function.
价 格:¥电议型 号:T62388产 地:中国大陆
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T62387CA IX-IN-1;化合物 CA IX-IN-1CA IX-IN-1
CA IX-IN-1 (compound 12g) is a potent and highly selective hCA IX inhibitor (IC50: 7 nM) that exhibits antitumour effects.
价 格:¥电议型 号:T62387产 地:中国大陆
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T62386(R)-Bicalutamide;化合物 (R)-Bicalutamide(R)-Bicalutamide
(R)-Bicalutamide is the R-type enantiomer of Bicalutamide, an androgen receptor (AR) antagonist that exhibits antitumour effects. (R)-Bicalutamide is widely used in prostate cancer research.
价 格:¥电议型 号:T62386产 地:中国大陆
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T62385Befiradol hydrochloride;化合物 Befiradol hydrochlorideNLX-112 hydrochloride|||F 13640 hydrochloride;NLX
Befiradol hydrochloride (NLX-112 hydrochloride) is a selective 5-hydroxytryptamine 1A (5-HT)1A receptor agonist with anxiolytic activity.Befiradol hydrochloride inhibits mutant ATXN3 aggregation.
价 格:¥电议型 号:T62385产 地:中国大陆
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T62383Anti-MRSA agent 2;化合物 Anti-MRSA agent 2Anti-MRSA agent 2
Anti-MRSA agent 2 (compound 14) is a good inhibitor of methicillin-resistant Staphylococcus aureus (MRSA) (MIC: 0.098 μg/ml) with relatively low toxicity to normal cells. anti-MRSA agent 2 is a strong disruptor of bacterial membranes and has a good ability to bind to bacterial genomic DNA.
价 格:¥电议型 号:T62383产 地:中国大陆
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T62382Tiagabine hydrochloride hydrate;化合物 Tiagabine hydrochloride hydrateTiagabine hydrochloride hydrate
Tiagabine hydrochloride hydrate is a potent and selective inhibitor of GABA uptake; it inhibits [3H] GABA uptake in synaptosomes, neurons and glia, with IC50 values of 67, 446 and 182 nM respectively. hydrate can be used as an anticonvulsant.
价 格:¥电议型 号:T62382产 地:中国大陆
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T62381Branaplam hydrochloride;化合物 Branaplam hydrochlorideBranaplam hydrochloride
Branaplam (LMI070; NVS-SM1) hydrochloride is a selective, orally active SMN2 splicing modulator that acts on SMN (EC50: 20 nM). branaplam hydrochloride inhibits hERG (IC50: 6.3 μM). In a mouse model of severe spinal muscular atrophy (SMA), Branaplam hydrochloride increased full-length SMN protein and improved survival.
价 格:¥电议型 号:T62381产 地:中国大陆
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T62380L20-HC-Me-Pyrrolidine FA;20-HC-Me-Pyrrolidine甲酸盐20-HC-Me-Pyrrolidine FA
20-HC-Me-Pyrrolidine FA is a potent inhibitor of Aster proteins, inhibiting Aster-A, Aster-B, and Aster-C, and inhibiting Aster protein binding and transfer of cholesterol.20-HC-Me-Pyrrolidine FA can be used in studies of lipid metabolism.20-HC-Me-Pyrrolidine FA is a potent inhibitor of Aster proteins.
价 格:¥电议型 号:T62380L产 地:中国大陆
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T6238020-HC-Me-Pyrrolidine;化合物 20-HC-Me-Pyrrolidine20-HC-Me-Pyrrolidine
20-HC-Me-Pyrrolidine was A potent inhibitor of Aster protein, with IC50 values of 0.11 μM, 0.06 μM and 0.71 μM for Aster A, Aster B and Aster C, respectively. 20-HC-Me-Pyrrolidine prevents Aster protein from binding and transferring cholesterol and inhibits the movement of low-density lipoprotein (LDL) cholesterol into the endoplasmic reticulum (ER).
价 格:¥电议型 号:T62380产 地:中国大陆
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T6238WZ4002;化合物WZ4002WZ4002
WZ4002 is a mutant-selective EGFR inhibitor for EGFR(L858R) and EGFR(T790M) with IC50 of 2 nM/8 nM.
价 格:¥电议型 号:T6238产 地:中国大陆
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T62379GGTI-286;化合物 GGTI-286GGTI-286
GGTI-286 is a potent, cell permeable GGTase I inhibitor (IC50: 2 μM). GGTI-286 inhibits Rap1A geranylation in NIH3T3 cells (IC50: 2 μM) more potently than H-Ras farnesylation (IC50>30 μM). Ras4B stimulation (IC50: 1 μM).
价 格:¥电议型 号:T62379产 地:中国大陆
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T62378(1R,2R)-ML-SI3;化合物 (1R,2R)-ML-SI3(1R,2R)-ML-SI3
(1R,2R)-ML-SI3 is a potent inhibitor of TRPML1 (IC50: 1.6 μM) and TRPML2 (IC50: 2.3 μM). (1R,2R)-ML-SI3 is also a weak inhibitor of TRPML3 with an IC50 value of 12.5 μM.
价 格:¥电议型 号:T62378产 地:中国大陆
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T62377Zofenopril;化合物 ZofenoprilZofenopril
Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50: 81 μM).
价 格:¥电议型 号:T62377产 地:中国大陆
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T62376GNE-9278;化合物 GNE-9278GNE-9278
GNE-9278 is a highly selective NMDAR orthosteric modulator that acts on the GluN1 transmembrane structural domain (TMD).GNE-9278 acts on activated NMDAR and increases peak current and agonist affinity.
价 格:¥电议型 号:T62376产 地:中国大陆
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T62375SARS-CoV-2 nsp13-IN-3;化合物 SARS-CoV-2 nsp13-IN-3SARS-CoV-2 nsp13-IN-3
SARS-CoV-2 nsp13-IN-3 (Compound C3) is a small molecule inhibitor of SARS-CoV-2 non-structural protein 13 (nsp13) that acts on nsp13 ssDNA+ATPase (IC50: 32 μM).
价 格:¥电议型 号:T62375产 地:中国大陆