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  • T63528HSP90-IN-11；化合物 HSP90-IN-11HSP90-IN-11

    HSP90-IN-11 is a potent inhibitor of HSP90 and induces significant accumulation of the sub-G1 population. HSP90-IN-11 has a potent HSP90α inhibitory effect comparable to that of AUY-922 (Luminespib). In CRC and NSCLC cells, HSP90-IN-11 exhibited significant anti-proliferative activity in the double-digit nM range.HSP90-IN-11 was able to rapidly degrade client proteins EGFR and Akt in NSCLC cells.

    价 格：￥电议型 号：T63528产 地：中国大陆

  • T63519Cap-dependent endonuclease-IN-13；化合物 Cap-dependent endonuclease-IN-13Cap-dependent endonuclease-IN-1

    Cap-dependent endonuclease-IN-13 is a potent inhibitor of cap-dependent endonuclease (CEN) and shows research potential against influenza virus infection (influenza A only).

    价 格：￥电议型 号：T63519产 地：中国大陆

  • T63512LpxC-IN-10；化合物 LpxC-IN-10LpxC-IN-10

    LpxC-IN-10 is a selective LpxC inhibitor with an MIC of 0.5 μg/mL against E. coli and K. pneumoniae and is capable of being used to study bacterial infections.

    价 格：￥电议型 号：T63512产 地：中国大陆

  • T63509Top/HDAC-IN-1；化合物 Top/HDAC-IN-1Top/HDAC-IN-1

    Top/HDAC-IN-1 is a dual topoisomerase (Top)/HDAC inhibitor that acts on HDAC1 (IC50: 18 nM), HDAC2 (IC50: 230 nM), HDAC3 (IC50: 790 nM), HDAC6 (IC50: 87 nM) and HDAC8 (IC50: 5250 nM). Top/HDAC-IN-1 exhibited potent antitumor effects on HCT116 cells (IC50: 180 nM), blocked the cell cycle of HCT116 cells in G2 phase, and effectively induced apoptosis.

    价 格：￥电议型 号：T63509产 地：中国大陆

  • T63497PI3Kδ/γ-IN-1；化合物 PI3Kδ/γ-IN-1PI3Kδ/γ-IN-1

    PI3Kδ/γ-IN-1 is a selective and effective inhibitor of PI3Kδ/γ that can be used in the treatment of hematologic malignancies.

    价 格：￥电议型 号：T63497产 地：中国大陆

  • T63496CYP2C9/CYP2C19-IN-1；化合物 CYP2C9/CYP2C19-IN-1CYP2C9/CYP2C19-IN-1

    CYP2C9/CYP2C19-IN-1 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.

    价 格：￥电议型 号：T63496产 地：中国大陆

  • T63490CDK9-IN-19；化合物 CDK9-IN-19CDK9-IN-19

    CDK9-IN-19 is a selective and potent CDK9 inhibitor (IC50: 2.0 nM). CDK9-IN-19 exhibits good anti-proliferative activity in cancer cells, moderate pharmacokinetic properties and low hERG inhibition. CDK9-IN-19 significantly inhibited tumor growth in the MV4-11 xenograft mouse model. CDK9-IN-19 can be used in studies of acute myeloid leukemia (AML).

    价 格：￥电议型 号：T63490产 地：中国大陆

  • T63481Tau-aggregation-IN-1；化合物 Tau-aggregation-IN-1Tau-aggregation-IN-1

    Tau-aggregation-IN-1 is a dopamine D2 and D3 receptor agonist and an inhibitor of tau441 protein aggregation (IC50: 21 μM).

    价 格：￥电议型 号：T63481产 地：中国大陆

  • T63479Caspase-3-IN-1；化合物 Caspase-3-IN-1Caspase-3-IN-1

    Caspase-3-IN-1 is a potent inhibitor of Caspase-3 (IC50: 14.5 nM).

    价 格：￥电议型 号：T63479产 地：中国大陆

  • T63471PARP1/BRD4-IN-1；化合物 PARP1/BRD4-IN-1PARP1/BRD4-IN-1

    PARP1/BRD4-IN-1 is a highly selective and potent inhibitor of PARP1 (IC50: 49 nM) and BRD4 (IC50: 202 nM).PARP1/BRD4-IN-1 inhibits the expression and activity of PARP1 and BRD4, thereby synergistically suppressing the malignant growth of pancreatic cancer cells.

    价 格：￥电议型 号：T63471产 地：中国大陆

  • T63468RET-IN-14；化合物 RET-IN-14RET-IN-14

    RET-IN-14 is a potent inhibitor of RET, capable of acting on RET (WT) (IC50 < 0.51 nM), RET (G810R) (IC50: 9.3 nM), RET (V804M) (IC50: 1.3 nM), BTK (C481S) (IC50: 9.2 nM) and BTK (C481S) (IC50 : 15 nM). RET-IN-14 exhibits potential for tumor studies.

    价 格：￥电议型 号：T63468产 地：中国大陆

  • T63464ERCC1-XPF-IN-1；化合物 ERCC1-XPF-IN-1ERCC1-XPF-IN-1

    ERCC1-XPF-IN-1 is a potent, high-affinity inhibitor of ERCC1-XPF (IC50: 0.49 μM). ERCC1-XPF-IN-1 inhibits the removal of CPDs, reduces the toxicity of cyclophosphamide to colorectal cancer cells, enhances the cytotoxic effects of UV radiation, and impedes DNA repair.

    价 格：￥电议型 号：T63464产 地：中国大陆

  • T63454PDGFRα/FLT3-ITD-IN-1；化合物 PDGFRα/FLT3-ITD-IN-1PDGFRα/FLT3-ITD-IN-1

    PDGFRα/FLT3-ITD-IN-1 are potent inhibitors of PDGFRα/FLT3, and their IC50 values are greater than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 exhibits investigational potential in acute myeloid leukemia or chronic eosinophilic leukemia.

    价 格：￥电议型 号：T63454产 地：中国大陆

  • T63453HIV-1 protease-IN-1；化合物 HIV-1 protease-IN-1HIV-1 protease-IN-1

    HIV-1 protease-IN-1 is a potent inhibitor of HIV-1 protease (IC50: 90 pM). HIV-1 protease-IN-1 has antiviral activity against B-HIV (EC50: 89 nM): HIV-1 protease-IN-1 was able to act on C-HIV strain ZM246 (EC50: 13.59 nM) and C-HIV strain Indie (EC50: 8.23 nM).

    价 格：￥电议型 号：T63453产 地：中国大陆

  • T63448BRAF V600E/CRAF-IN-1；化合物 BRAF V600E/CRAF-IN-1BRAF V600E/CRAF-IN-1

    BRAF V600E/CRAF-IN-1 is a potent inhibitor of BRAFV600E/CRAF. BRAF V600E/CRAF-IN-1 acts in the G0/G1 phase of HCT-116 colon cancer cells to arrest the cell cycle and cause apoptosis. BRAF V600E/CRAF-IN-1 shows potential for cancer disease research.

    价 格：￥电议型 号：T63448产 地：中国大陆

  • T63447FTO-IN-1 TFA；化合物 FTO-IN-1 TFAFTO-IN-1 TFA

    FTO-IN-1 TFA is an inhibitor of adiposity and obesity-related enzymes (FTO) (IC50 < 1 μM).FTO-IN-1 TFA can be used to study cancer.

    价 格：￥电议型 号：T63447产 地：中国大陆

  • T63435PTP1B-IN-16；化合物 PTP1B-IN-16PTP1B-IN-16

    PTP1B-IN-16 is a promising and selective benzimidazole derivative and an inhibitor of protein tyrosine phosphatase 1B (PTP1B) (Ki: 12.6 μM).PTP1B-IN-16 can be used to study type 2 diabetes.

    价 格：￥电议型 号：T63435产 地：中国大陆

  • T63426mGAT3/4-IN-1；化合物 mGAT3/4-IN-1mGAT3/4-IN-1

    mGAT3/4-IN-1 is a potent inhibitor of mGAT3/mGAT4, and their pIC50 values were 5.31 and 5.24, respectively. mGAT3/4-IN-1 significantly inhibited tactile abnormal pain in diabetic neuropathic mice.

    价 格：￥电议型 号：T63426产 地：中国大陆

  • T63410CDK7-IN-17；化合物 CDK7-IN-17CDK7-IN-17

    CDK7-IN-17 is a pyrimidine-derived compound and a potent inhibitor of CDK7. CDK7-IN-17 has shown research potential for a variety of cancers, particularly those with dysregulated transcription.

    价 格：￥电议型 号：T63410产 地：中国大陆

  • T63401EGFR/HER2/TS-IN-1；化合物 EGFR/HER2/TS-IN-1EGFR/HER2/TS-IN-1

    EGFR/HER2/TS-IN-1 are EGFR, HER2 and TS (Thymidylate synthase) inhibitors with IC50 values of 0.203, 0.088 and 0.168 μM, respectively, and have the ability to induce apoptosis (MCF7 cell death).

    价 格：￥电议型 号：T63401产 地：中国大陆

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