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  • T63182BTK-IN-15；化合物 BTK-IN-15BTK-IN-15

    BTK-IN-15 is a novel, orally active Bruton´s tyrosine kinase (BTK) inhibitor that inhibits BTK (IC50: 0.7 nM). BTK-IN-15 induces apoptosis in cancer cells and has good kinase selectivity and anti-tumour activity.

    价 格：￥电议型 号：T63182产 地：中国大陆

  • T63176ALPK1-IN-1；化合物 ALPK1-IN-1ALPK1-IN-1

    ALPK1-IN-1 (Compound A001) is a potent inhibitor of alpha-kinase 1 (ALPK1). ALPK1 is an intracytoplasmic serine/threonine protein kinase that plays an important role in activating the innate immune response to bacteria by interacting with TRAF proteins of the forkhead-associated structural domain (TIFA)-dependent pro-inflammatory NF-κB signalling pathway.

    价 格：￥电议型 号：T63176产 地：中国大陆

  • T63174FLT3-IN-17；化合物 FLT3-IN-17FLT3-IN-17

    FLT3-IN-17 is an FAK inhibitor (IC50: 12 nM). FLT3-IN-17 inhibits the activity of CYPs and FLT3 mutants and has an IC50 of <0.5 nM for D835Y. FLT3-IN-17 can be used in cancer research.

    价 格：￥电议型 号：T63174产 地：中国大陆

  • T63169MIF2-IN-1；化合物 MIF2-IN-1MIF2-IN-1

    MIF2-IN-1 (compound 5d) is a potent MIF2 tautomerase inhibitor (IC50: 1.0 μM). MIF2-IN-1 inhibits the proliferation of non-small cell lung cancer cells by arresting the cell cycle through the MAPK pathway. MIF2-IN-1 has the potential to study cancer diseases.

    价 格：￥电议型 号：T63169产 地：中国大陆

  • T63158hCAIX-IN-10；化合物 hCAIX-IN-10hCAIX-IN-10

    hCAIX-IN-10 (Compound 6i) is a selective inhibitor of carbonic anhydrase IX and XII, acting on hCA IX (Ki: 61.5 nM) and hCA XII (Ki: 586.8 nM). hCA IX and hCA XII are transmembrane isoforms of carbonic anhydrase that act as biomarkers for some types of tumours. hCA XII contributes to the maintenance of acid-base homeostasis in normal and tumour cells.

    价 格：￥电议型 号：T63158产 地：中国大陆

  • T63154Axl-IN-10；化合物 Axl-IN-10Axl-IN-10

    Axl-IN-10 is a potent inhibitor of AXL (IC50: 5 nM).Axl-IN-10 has good pharmacokinetic properties in animals and excellent transmembrane properties.Axl-IN-10 can be used to study proliferative, allergic, autoimmune, inflammatory, transplant rejection, cancer or other mammalian diseases.

    价 格：￥电议型 号：T63154产 地：中国大陆

  • T63146JAK2/TYK2-IN-1；化合物 JAK2/TYK2-IN-1JAK2/TYK2-IN-1

    JAK2/TYK2-IN-2 is a potent and selective inhibitor of TYK2 (IC50: 9 nM) and JAK2 (IC50: 157 nM) with anti-inflammatory effects.

    价 格：￥电议型 号：T63146产 地：中国大陆

  • T63142AChE/HDAC-IN-1；化合物 AChE/HDAC-IN-1AChE/HDAC-IN-1

    COX-2-IN-23 (compound A10) is a potent inhibitor of AChE (IC50: 0.12 nM) and HDAC (IC50: 0.23 nM).COX-2-IN-23 exhibits antioxidant and metal chelating properties.COX-2-IN-23 can be used to study Alzheimer´s disease.

    价 格：￥电议型 号：T63142产 地：中国大陆

  • T63139Glutaminyl cyclases-IN-1；化合物 Glutaminyl cyclases-IN-1Glutaminyl cyclases-IN-1

    Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent inhibitor of Glutaminyl cyclases (QC), which acts on human QC (IC50: 12 nM) and isoQC (IC 50:73 nM). Glutaminyl cyclases-IN-1 inhibited isoQC and selectively blocked CD47/SIRPα interaction. Glutaminyl cyclases-IN-1 also enhanced phagocytosis of THP-1 and U937 macrophages.

    价 格：￥电议型 号：T63139产 地：中国大陆

  • T63138PRMT5-IN-16；化合物 PRMT5-IN-16PRMT5-IN-16

    PRMT5-IN-16 (Compound 20) is a PRMT5 inhibitor with antitumour effects. PRMT5, a protein arginine methyltransferase, is a novel anti-tumour target associated with epigenetic modifications.

    价 格：￥电议型 号：T63138产 地：中国大陆

  • T63135FLT3/CDK4-IN-1；化合物 FLT3/CDK4-IN-1FLT3/CDK4-IN-1

    FLT3/CDK4-IN-1 is a highly selective, potent, orally active dual inhibitor of FLT3/CDK4, acting on FLT3 (IC50: 7 nM) and CDK4 (IC50: 11 nM).FLT3/CDK4-IN-1 has good anti-tumour effects in vivo, showing anti-proliferative effects on some cancer cells.

    价 格：￥电议型 号：T63135产 地：中国大陆

  • T63131ZIKV-IN-1；化合物 ZIKV-IN-1ZIKV-IN-1

    ZIKV-IN-1 is a potent inhibitor of zika virus (EC50: 2.8 μM, EC90: 6.8 μM). zIKV-IN-1 has anti-ZIKV effects and low cytotoxicity. zIKV-IN-1 shows high affinity for the RdRp domain of ZIKV.

    价 格：￥电议型 号：T63131产 地：中国大陆

  • T63122CBP/p300-IN-19；化合物 CBP/p300-IN-19CBP/p300-IN-19

    CBP/p300-IN-19 is a potent inhibitor of p300/CBP HAT, which can act on P300-HAT (IC50: 1.4 μM), CBP-HAT (IC50: 1.4 μm), 2.2 μM), PCAF (IC50>100 μM), and Myst3 (IC50>100 μM). CBP/p300-IN-19 has anti-tumor activity.

    价 格：￥电议型 号：T63122产 地：中国大陆

  • T63119NF-κB/MAPK-IN-1；NF-κB/MAPK抑制剂1NF-κB/MAPK-IN-1

    NF-κB/MAPK-IN-1 is a potent dual inhibitor of the NF-κB and MAPK pathways with potential anti-inflammatory activity, inhibition of NO production, and inhibition of LPS-induced activation of iNOS, COX-2, ERΚ and P38. NF-κB/MAPK-IN-1 is used for the prevention and treatment of rheumatoid arthritis (RA).

    价 格：￥电议型 号：T63119产 地：中国大陆

  • T63110CBP/p300-IN-15；化合物 CBP/p300-IN-15CBP/p300-IN-15

    CBP/p300-IN-15 (compound 13a) is a potent inhibitor of p300 (IC50: 2.5 nM) and CBP (IC50: 28.0 nM). p300-IN-15 inhibits OVCAR-3 cells (EC50: 0.865 μM) and A2780 cells (EC50. 2.71 μM). 2.71 μM). CBP/p300-IN-15 can be used to study ovarian cancer.

    价 格：￥电议型 号：T63110产 地：中国大陆

  • T63108CDK7-IN-14；化合物 CDK7-IN-14CDK7-IN-14

    CDK7-IN-14 is a pyrimidine-derived compound that is a potent inhibitor of CDK7. CDK7-IN-14 has the potential to be investigated in a variety of cancers, particularly those with transcriptional dysregulation.

    价 格：￥电议型 号：T63108产 地：中国大陆

  • T63104iNOS/PGE2-IN-1；化合物 iNOS/PGE2-IN-1iNOS/PGE2-IN-1

    iNOS/PGE2-IN-1 is an iNOS/PGE2 inhibitor and a potent anti-inflammatory agent. iNOS/PGE2-IN-1 exhibits an inhibitory effect on LPS-induced NO production and has a low ulcerogenic potential.

    价 格：￥电议型 号：T63104产 地：中国大陆

  • T63103PRMT5-IN-17；化合物 PRMT5-IN-17PRMT5-IN-17

    PRMT5-IN-17 (Compound 6) is a PRMT5 inhibitor that exhibits antitumour activity. PRMT5, a protein arginine methyltransferase, is a novel anti-tumour target associated with epigenetic modifications.

    价 格：￥电议型 号：T63103产 地：中国大陆

  • T63102SIRT2-IN-10；化合物 SIRT2-IN-10SIRT2-IN-10

    SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases.

    价 格：￥电议型 号：T63102产 地：中国大陆

  • T63086SYK/JAK-IN-1；化合物 SYK/JAK-IN-1SYK/JAK-IN-1

    SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.

    价 格：￥电议型 号：T63086产 地：中国大陆

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