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T62898Glucosylceramide synthase-IN-1；化合物 Glucosylceramide synthase-IN-1Glucosylceramide synthase-IN-1
Glucosylceramide synthase-IN-1 (T-036) is a potent, orally active, blood-brain barrier permeable glucosylceramide synthase (GCS) inhibitor that acts on human GCS (IC50: 31 nM) and mouse GCS (IC50: 51 nM). Glucosylceramide synthase-IN-1 can be used to study Gaucher disease.
价 格：￥电议型 号：T62898产 地：中国大陆
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T62896EZH2-IN-12；化合物 EZH2-IN-12EZH2-IN-12
EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.
价 格：￥电议型 号：T62896产 地：中国大陆
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T62892hCAI/II-IN-1；化合物 hCAI/II-IN-1hCAI/II-IN-1
hCAI/II-IN-1 (Compound 3h) is a human carbonic anhydrase I and II (hCA I/II) inhibitor that acts on hCA I (IC50: 0.047 μM) and hCA II (IC50: 0.024 μM).
价 格：￥电议型 号：T62892产 地：中国大陆
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T62891α-Glucosidase-IN-19；化合物 α-Glucosidase-IN-19α-Glucosidase-IN-19
Alpha-Glucosidase-IN-19 (Compound 6B) is an orally active alpha-glucosidase inhibitor (IC50: 3.63 μM) with antidiabetic effects.
价 格：￥电议型 号：T62891产 地：中国大陆
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T62890OXPHOS-IN-1；化合物 OXPHOS-IN-1OXPHOS-IN-1
OXPHOS-IN-1 (compound 2) is an inhibitor of oxidative phosphorylation (OXPHOS) and inhibits the growth of MIA PaCa-2 cells (IC50: 2.34 μM) and BxPC-3 cells (IC50: 13.82 μM).
价 格：￥电议型 号：T62890产 地：中国大陆
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T62872PDGFR-IN-1；化合物 PDGFR-IN-1PDGFR-IN-1
PDGFR-IN-1 (compound 7m) is an orally active PDGFR (platelet-derived growth factor receptor) inhibitor that acts on PDGFRα (IC50: 2.4 nM) and PDGFRβ (IC50: 0.9 nM). PDGFR-IN-1 exhibits strong anti-tumour effects and low toxicity, allowing it to be used in the study of osteosarcoma.
价 格：￥电议型 号：T62872产 地：中国大陆
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T62861ERAP2-IN-1；化合物 ERAP2-IN-1ERAP2-IN-1
ERAP2-IN-1 (compound 61) is a non-competitive inhibitor of ERAP2. ERAP2-IN-1 specifically inhibits the hydrolytic activity of ERAP2 peptides, inhibiting Arg-AMC hydrolysis (IC50: 27 μM) and the hydrolytic activity of model peptides (IC50: 44 μM).
价 格：￥电议型 号：T62861产 地：中国大陆
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T62859MEIS-IN-1；化合物 MEIS-IN-1MEIS-IN-1
MEIS-IN-1 is a potent MEIS inhibitor that induces the expansion of hematopoietic stem cells in mice and humans.
价 格：￥电议型 号：T62859产 地：中国大陆
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T62855OX2R-IN-1；化合物 OX2R-IN-1OX2R-IN-1
OX2R-IN-1 is an OX2R antagonist (a potential OX2R binding agent) that exhibits low cytotoxicity (IC50: 484 μM). oX2R-IN-1 has blood-brain barrier permeability and a short drug half-life.
价 格：￥电议型 号：T62855产 地：中国大陆
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T62850IRAK4-IN-13；化合物 IRAK4-IN-13IRAK4-IN-13
IRAK4-IN-13 (compound 21) is a selective and potent IRAK4 inhibitor (IC50: 0.6 nM). iRAK4-IN-13 has a high metabolic clearance, with an intrinsic human liver microsomal (HLM) clearance of 96 μL/min/mg.
价 格：￥电议型 号：T62850产 地：中国大陆
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T62830SGLT1/2-IN-1；化合物 SGLT1/2-IN-1SGLT1/2-IN-1
SGLT1/2-IN-1 is a dual SGLT1/SGLT2 inhibitor.
价 格：￥电议型 号：T62830产 地：中国大陆
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T62829SARS-CoV-2 nsp14-IN-1；化合物 SARS-CoV-2 nsp14-IN-1SARS-CoV-2 nsp14-IN-1
SARS-CoV-2 nsp14-IN-1 (Compound 3) is a typical dual-substrate inhibitor of SARS-CoV-2Nsp14 Mtase (IC50: 0.061 μM). Histone lysine, protein arginine, DNA and RNA, etc.).
价 格：￥电议型 号：T62829产 地：中国大陆
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T62828FRα-IN-1；化合物 FRα-IN-1FRα-IN-1
FRα-IN-1 (Compound 4) is a tumour targeting agent. FRα-IN-1 exhibits selective anti-cancer effects on FRα and FRβ expressing cells.
价 格：￥电议型 号：T62828产 地：中国大陆
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T62818LSD1/ER-IN-1；化合物 LSD1/ER-IN-1LSD1/ER-IN-1
LSD1/ER-IN-1 (compound 11g) is a potent inhibitor of ER and LSD1 that acts on LSD1 (IC50: 1.55 μM). LSD1/ER-IN-1 showed good anti-proliferative effect on MCF-7 breast cancer cells (IC50: 8.79 μM).
价 格：￥电议型 号：T62818产 地：中国大陆
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T62815PRMT5-IN-1 hydrochloride；化合物 PRMT5-IN-1 hydrochloridePRMT5-IN-1 hydrochloride
PRMT5 IN-1 hydrochloride (compound 9) is a hemiacetalamine, a potent inhibitor of the selective protein arginine methyltransferase 5 (PRMT5) with an inhibitory effect on PRMT5/MEP50 (IC50: 11 nM). PRMT5 IN-1 hydrochloride can be converted to an aldehyde under physiological conditions and reacts with C449 to form a covalent adduct.
价 格：￥电议型 号：T62815产 地：中国大陆
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T62803STAT3-IN-12；化合物 STAT3-IN-12STAT3-IN-12
STAT3-IN-12 is a potent inhibitor of STAT3 signalling and inhibits IL-6-induced activation of the JAK/STAT3 signalling pathway. STAT3-IN-12 inhibits the growth and migration of cancer cells, blocks the cell cycle and induces apoptosis. HCC), oesophageal cancer.)
价 格：￥电议型 号：T62803产 地：中国大陆
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T62801FLT3/TrKA-IN-1；化合物 FLT3/TrKA-IN-1FLT3/TrKA-IN-1
FLT3/TrKA-IN-1 is a potent FLT3/TrKA dual kinase inhibitor, capable of acting on FLT3 (IC50: 43.8 nM), FLT3-ITD (IC50: 97.2 nM), FLT3-TKD (IC50: 92.5 nM) and TrKA (IC50: 23.6 nM). -FLT3/TrKA-IN-1 has potential for acute myeloid leukaemia (AML) studies.
价 格：￥电议型 号：T62801产 地：中国大陆
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T62800HPK1-IN-16；化合物 HPK1-IN-16HPK1-IN-16
HPK1-IN-16 is a selective and potent inhibitor of HPK1. HPK1-IN-16 can be used for the study, prevention or amelioration of diseases or conditions associated with HPK1 activity, such as cancer.
价 格：￥电议型 号：T62800产 地：中国大陆
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T62796VEGFR-2-IN-13；化合物 VEGFR-2-IN-13VEGFR-2-IN-13
VEGFR-2-IN-13 (Compound 19a) is a potent VEGFR-2 inhibitor (IC50: 3.4 nM). vEGFR-2-IN-13 arrests the HepG2 cell cycle in G2/M phase and induces apoptosis.
价 格：￥电议型 号：T62796产 地：中国大陆
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T6279214α-Demethylase/DNA Gyrase-IN-1；化合物 14α-Demethylase/DNA Gyrase-IN-114α-Demethylase/DNA Gyrase-IN-1
14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.
价 格：￥电议型 号：T62792产 地：中国大陆
