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T62466HBV-IN-17;化合物 HBV-IN-17HBV-IN-17
HBV-IN-17 (compound 8) is a potent regulator of HBV capsid assembly (EC50: 511 nM).
价 格:¥电议型 号:T62466产 地:中国大陆
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T62465Urease-IN-1;化合物 Urease-IN-1Urease-IN-1
Urease -IN-1 is a urease inhibitor (IC50: 2.21±0.45 μM).
价 格:¥电议型 号:T62465产 地:中国大陆
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T62456ALR1/2-IN-1;化合物 ALR1/2-IN-1ALR1/2-IN-1
ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) (IC50: 3.26 μM) and aldose reductase (ALR2) (IC50: 3.06 μM) inhibitor with anticancer effects.
价 格:¥电议型 号:T62456产 地:中国大陆
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T62454Galectin-3-IN-1;化合物 Galectin-3-IN-1Galectin-3-IN-1
Galectin-3-IN-1 (Compound 1) is a potent inhibitor of polyvalent galactose lectin-3 (Gal-3). Galectin-3 is involved in many metabolic processes associated with cancer.
价 格:¥电议型 号:T62454产 地:中国大陆
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T62451TYK2-IN-12;化合物 TYK2-IN-12TYK2-IN-12
TYK2-IN-12 (compound 30) is a selective, orally active inhibitor of TYK2 (tyrosine kinase 2) (Ki: 0.51 nM). TYK2-IN-12 inhibits IL-12-induced IFNγ in human and mouse whole blood with IC50 values of 2.7 and 7.0 μM, respectively. 12 can be used to study psoriasis.
价 格:¥电议型 号:T62451产 地:中国大陆
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T62441AChE-IN-14;化合物 AChE-IN-14AChE-IN-14
AChE-IN-14 is a potent cholinesterase inhibitor, acting on electric eel acetylcholinesterase (eeAChE) (IC50: 0.46 μM), human recombinant acetylcholinesterase (hAChE) (IC50: 0.48 μM) and equine serum butyrylcholinesterase (eqBuChE) (IC50: 0.44 μM). AChE-IN-14 has a high affinity for the human H3 receptor (H3R) (Ki: 159.8 nM) and can be used to study Alzheimer´s disease.
价 格:¥电议型 号:T62441产 地:中国大陆
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T62439VEGFR-2-IN-14;化合物 VEGFR-2-IN-14VEGFR-2-IN-14
VEGFR-2-IN-14 (Compound 5) is a potent inhibitor of VEGFR-2, which inhibits the growth of HepG2 cells in the Pre-G1 phase and induces apoptosis.
价 格:¥电议型 号:T62439产 地:中国大陆
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T62434HBV-IN-10;化合物 HBV-IN-10HBV-IN-10
HBV-IN-10 is an isomer of compound 6 (WO2021204258A1). Compound 6 is a potent inhibitor of hepatitis B surface antigen (HBsAg) (0.1 μM < EC50 ≤ 1 μM).
价 格:¥电议型 号:T62434产 地:中国大陆
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T62433(5S,8R)-HBV-IN-10;化合物 (5S,8R)-HBV-IN-10(5S,8R)-HBV-IN-10
(5S,8R)-HBV-IN-10 is an isomer of compound 6 (WO2021204258A1). Compound 6 is a potent inhibitor of hepatitis B surface antigen (HBsAg) (0.1 μM< EC50≤1 μM).
价 格:¥电议型 号:T62433产 地:中国大陆
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T62429TRK-IN-14;化合物 TRK-IN-14TRK-IN-14
TRK-IN-14 is a potent inhibitor of TRK. TRK-IN-13 has shown potential for TRK-related diseases.
价 格:¥电议型 号:T62429产 地:中国大陆
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T62428TRK-IN-13;化合物 TRK-IN-13TRK-IN-13
TRK-IN-13 is a potent inhibitor of TRK. TRK-IN-13 has shown potential for the study of TRK-related diseases.
价 格:¥电议型 号:T62428产 地:中国大陆
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T62423GCPII-IN-1 TFA;化合物 GCPII-IN-1 TFAGCPII-IN-1 TFA
GCPII-IN-1 TFA is a glutamate carboxypeptidase II (GCPII; PSMA) inhibitor scaffold (Ki: 44.3 nM).
价 格:¥电议型 号:T62423产 地:中国大陆
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T62418hACC2-IN-1;化合物 hACC2-IN-1hACC2-IN-1
hACC2-IN-1 is a potent inhibitor of acetyl coenzyme A carboxylase 2 (ACC2) with an IC50 value of 2.5 μM for hACC2. hACC2-IN-1 has potential for obesity studies.
价 格:¥电议型 号:T62418产 地:中国大陆
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T62415CBP/p300-IN-17;化合物 CBP/p300-IN-17CBP/p300-IN-17
CBP/p300-IN-17 (compound 7) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.18 μM) and LK2 H3K27 (IC50: 0.69 μM).
价 格:¥电议型 号:T62415产 地:中国大陆
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T62414Dyrk1A-IN-1;化合物 Dyrk1A-IN-1Dyrk1A-IN-1
Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.
价 格:¥电议型 号:T62414产 地:中国大陆
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T62413SARS-CoV-2 nsp13-IN-1;化合物 SARS-CoV-2 nsp13-IN-1SARS-CoV-2 nsp13-IN-1
SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent inhibitor of nsp13 (non-structural protein 13). SARS-CoV-2 nsp13-IN-1 inhibits only nsp13 ssDNA+ATPase (IC50: 6 μM), but not ssDNA-ATPase. CoV-2 nsp13-IN-1 was able to be used to study COVID-19.
价 格:¥电议型 号:T62413产 地:中国大陆
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T62412FLT3-IN-12;化合物 FLT3-IN-12FLT3-IN-12
FLT3-IN-12 is a selective, potent, orally active FLT3 kinase inhibitor that acts on FLT3-WT (IC50: 1.48 nM) and FLT3-D835Y (IC50: 2.87 nM). FLT3-IN-12 is more selective than c-KIT (>1000-fold). FLT3-IN-12 showed significant anti-AML effects, with an IC50 value of 0.75 nM for MV4-11 cells.
价 格:¥电议型 号:T62412产 地:中国大陆
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T62408PI3Kδ-IN-11;化合物 PI3Kδ-IN-11PI3Kδ-IN-11
PI3Kδ-IN-11 is a potent and selective PI3Kδ inhibitor (IC50: 27.5 nM) that dose-dependently blocks PI3K/Akt pathway activity. PI3Kδ-IN-11 can be used in B- or T-cell-associated malignancy studies.
价 格:¥电议型 号:T62408产 地:中国大陆
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T62405KDM1/CDK1-IN-1;化合物 KDM1/CDK1-IN-1KDM1/CDK1-IN-1
KDM1/CDK1-IN-1 (compound 4) is a potent inhibitor of KDM1 (IC50: 0.096 μM) and CDK1 (IC50: 0.078 μM). kDM1/CDK1-IN-1 blocks the cell cycle of HOP-92 cells in G2/M phase and induces apoptosis. KDM1/CDK1-IN-1 is highly cytotoxic to CCRF-CEM cells (IC50: 16.34 μM), HOP-92 cells (IC50: 3.45 μM) and Hep-G2 cells (IC50: 7.79 μM).
价 格:¥电议型 号:T62405产 地:中国大陆
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T62387CA IX-IN-1;化合物 CA IX-IN-1CA IX-IN-1
CA IX-IN-1 (compound 12g) is a potent and highly selective hCA IX inhibitor (IC50: 7 nM) that exhibits antitumour effects.
价 格:¥电议型 号:T62387产 地:中国大陆