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  • T62371SOS1-IN-12；化合物 SOS1-IN-12SOS1-IN-12

    SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).

    价 格：￥电议型 号：T62371产 地：中国大陆

  • T62369Tubulin polymerization-IN-17；化合物 Tubulin polymerization-IN-17Tubulin polymerization-IN-17

    Tubulin aggregation-IN-17 (compound 23g) is a potent inhibitor of tubulin aggregation. tubulin aggregation-IN-17 has a microtubulin-depolymerising effect, induces apoptosis and inhibits migration. tubulin aggregation-IN-17 has potential for cancer disease research. Tubulin aggregation-IN-17 has potential for cancer disease research.

    价 格：￥电议型 号：T62369产 地：中国大陆

  • T62359TLR4/NF-κB/MAPK-IN-1；化合物 TLR4/NF-κB/MAPK-IN-1TLR4/NF-κB/MAPK-IN-1

    TLR4/NF-κB/MAPK-IN-1 is a novel antineuroinflammatory agent that functions by inhibiting the TLR4/NF-κB/MAPK pathways.

    价 格：￥电议型 号：T62359产 地：中国大陆

  • T62355HBV-IN-14；化合物 HBV-IN-14HBV-IN-14

    HBV-IN-14 is a pyridinopyrimidinone compound and a potent covalent closed-loop DNA (cccDNA) inhibitor. HBV-IN-14 has potential for the study of HBV infection.

    价 格：￥电议型 号：T62355产 地：中国大陆

  • T62350XO/COX/LOX-IN-1；化合物 XO/COX/LOX-IN-1XO/COX/LOX-IN-1

    XO/COX/LOX-IN-1 is a potent inhibitor of xanthine oxidase/cyclooxygenase/lipoxygenase XO/COX/LOX. XO/COX/LOX-IN-1 can be used in the study of inflammatory, cancer and metabolic diseases.

    价 格：￥电议型 号：T62350产 地：中国大陆

  • T62337CDK2-IN-11；化合物 CDK2-IN-11CDK2-IN-11

    CDK2-IN-11 (compound 9d) is a potent inhibitor of CDK2 (IC50: 6.4 μM) and acts on hCA II (Ki: 23.4 nM), hCA IX (Ki: 56.3 nM) and hCA XII (Ki: 44.3 nM). CDK2-IN-11 can be used in anticancer studies.

    价 格：￥电议型 号：T62337产 地：中国大陆

  • T62331Autophagy-IN-1；化合物 Autophagy-IN-1Autophagy-IN-1

    Autophagy-IN-1 is a potent inhibitor of autophagy/mitophagy, blocking autophagosomal-lysosomal fusion in cancer cells while selectively increasing autophagic flux. Autophagy-IN-1 significantly inhibits tumour growth in the HCT116 mouse xenograft tumour model with low toxicity.Autophagy-IN-1 can be used to study colorectal cancer.

    价 格：￥电议型 号：T62331产 地：中国大陆

  • T62327HDAC2-IN-1；化合物 HDAC2-IN-1HDAC2-IN-1

    HDAC2-IN-1 (Compound 17) is an orally active, competitive HDAC2 inhibitor (IC50: 0.5 μM) that crosses the blood-brain barrier. HDAC2-IN-1 also inhibits HDAC1 (IC50: 1.61 μM) and HDAC8 (IC50: 0.98 μM).

    价 格：￥电议型 号：T62327产 地：中国大陆

  • T62313CSF1R-IN-10；化合物 CSF1R-IN-10CSF1R-IN-10

    CSF1R-IN-10 (Compound 48) is a CSF-1R inhibitor (IC50: 0.005 μM).

    价 格：￥电议型 号：T62313产 地：中国大陆

  • T62307Aha1/Hsp90-IN-1；化合物 Aha1/Hsp90-IN-1Aha1/Hsp90-IN-1

    Aha1/Hsp90-IN-1 (Compound 17) is an inhibitor of the Aha1/Hsp90 complex and has an inhibitory effect on tau protein aggregation.Aha1/Hsp90-IN-1 disrupts the Aha1/Hsp90 interaction (IC50: 3.32 μM).

    价 格：￥电议型 号：T62307产 地：中国大陆

  • T62306Human enteropeptidase-IN-1；化合物 Human enteropeptidase-IN-1Human enteropeptidase-IN-1

    Human enteropeptidase-IN-1 (compound 6b) is an orally active and potent enteropeptidase inhibitor with low systemic exposure. Human enteropeptidase-IN-1 can be used to study anti-obesity.

    价 格：￥电议型 号：T62306产 地：中国大陆

  • T62303PDE4B/7A-IN-1；化合物 PDE4B/7A-IN-1PDE4B/7A-IN-1

    Compound 22, a 5-hydroxynitrile rubber 7 receptor antagonist (5-HT1A Ki=8 nm, Kb=0.04 nm; 5-nitrile rubber 7K I=451 nm, Kb=460 nm), exhibits inhibitory activity against PDE4B/PDE7A (PDE4B IC50=80.4 μM; PDE7A IC50=151.3 μM). It demonstrates significant passive biofilm penetration capabilities and high metabolic stability in vitro. Pharmacological assessment has revealed precognitive and antidepressant effects in rat behavioral tests, highlighting its potential therapeutic applications.

    价 格：￥电议型 号：T62303产 地：中国大陆

  • T62298PHD2/HDACs-IN-1；化合物 PHD2/HDACs-IN-1PHD2/HDACs-IN-1

    PHD2/HDACs-IN-1 is a potent mixed inhibitor of PHD2/HDACs, acting on PHD2 (IC50: 1.15 μM), HDAC1 (IC50: 19.75 μM), HDAC2 (IC50: 26.60 μM), HDAC16 (IC50: 15.98 μM). HDACs-IN-1 is a low toxicity nephroprotective agent that can be used in studies of cisplatin-induced acute kidney injury (AKI).

    价 格：￥电议型 号：T62298产 地：中国大陆

  • T62293CDK8-IN-11 hydrochloride；化合物 CDK8-IN-11 hydrochlorideCDK8-IN-11 hydrochloride

    CDK8-IN-11 hydrochloride is a selective and potent inhibitor of CDK8 (IC50: 46 nM). CDK8-IN-11 hydrochloride inhibits the WNT/β-catenin signalling pathway. CDK8-IN-11 hydrochloride can be used to study colon cancer.

    价 格：￥电议型 号：T62293产 地：中国大陆

  • T62289PI3KC2α-IN-1；化合物 PI3KC2α-IN-1PI3KC2α-IN-1

    PI3KC2α-IN-1 is a potent inhibitor of PI3KC2α with an IC50 value of 95 nM. PI3KC2α-IN-1 interacts with the ATP binding site of PI3KC2α. PI3KC2α-IN-1 impairs the kinetics of endocytosis and membrane remodelling. PI3KC2α-IN-1 can be used to study thrombosis, diabetes and cancer. and cancer.

    价 格：￥电议型 号：T62289产 地：中国大陆

  • T62270IDO-IN-14；化合物 IDO-IN-14IDO-IN-14

    IDO-IN-14 is an IDO inhibitor (IC50: 0.6928 nM).

    价 格：￥电议型 号：T62270产 地：中国大陆

  • T62260FLT3-IN-11；化合物 FLT3-IN-11FLT3-IN-11

    FLT3-IN-11 (compound 30) is an orally active, potent and selective inhibitor of FLT3 kinase, acting on wild-type FLT3 (IC50: 7.22 nM) and FLT3-D835Y (IC50: 4.95 nM). FLT3-IN-11 exhibited significant anti-AML effects with an IC50 value of 3.2 nM for MV4-11 cells.

    价 格：￥电议型 号：T62260产 地：中国大陆

  • T62256HBV-IN-11；化合物 HBV-IN-11HBV-IN-11

    HBV-IN-11 is a potent inhibitor of HBsAg secretion (EC50: 0.46 μM).

    价 格：￥电议型 号：T62256产 地：中国大陆

  • T62254TLR9-IN-1；化合物 TLR9-IN-1TLR9-IN-1

    TLR9-IN-1 is a selective and potent TLR9 inhibitor that acts on human TLR9 (IC50: 7 nM). TLR9-IN-1 can be used in the study of adverse immune response-related diseases.

    价 格：￥电议型 号：T62254产 地：中国大陆

  • T62249Bcl-2/Mcl-1-IN-1；化合物 Bcl-2/Mcl-1-IN-1Bcl-2/Mcl-1-IN-1

    Bcl-2/Mcl-1-IN-1 is an inhibitor of Bcl-2 (Ki: 4.53 μM) and Mcl-1 (Ki: 1.19 μM).Bcl-2/Mcl-1-IN-1 can be used in cancer research.

    价 格：￥电议型 号：T62249产 地：中国大陆

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