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T60373SIRT1-IN-2；化合物 SIRT1-IN-2SIRT1-IN-2
SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1) with an IC 50 of 1.6 μM [1].
价 格：￥电议型 号：T60373产 地：中国大陆
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T60370Metallo-β-lactamase-IN-2；化合物 Metallo-β-lactamase-IN-2Metallo-β-lactamase-IN-2
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor with IC 50 values of 0.1 μM for VIM-1, 1.3 μM for NDM-1 and 5.0 μM for IMP-7, respectively [1].
价 格：￥电议型 号：T60370产 地：中国大陆
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T60362LSD1-IN-22；化合物 LSD1-IN-22LSD1-IN-22
LSD1-IN-22 is a potent inhibitor of Lysine-specific demethylase 1 ( LSD1 ) with a K i value of 98 nM. LSD1-IN-22 has anti-proliferative activity against certain cancer cells [1].
价 格：￥电议型 号：T60362产 地：中国大陆
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T60357NF-κB-IN-2；化合物 NF-κB-IN-2JEUD-38；JEUD-38
NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.
价 格：￥电议型 号：T60357产 地：中国大陆
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T60299MurA-IN-2；化合物 MurA-IN-2MurA-IN-2
MurA-IN-2 (compound 37), a potent MurA inhibitor characterized by a chloroacetamide fragment with a primary aliphatic amine, exhibits antibacterial activity by inhibiting bacterial cell wall synthesis, demonstrated by an IC50 of 39 μM [1].
价 格：￥电议型 号：T60299产 地：中国大陆
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T60294FBPase-IN-2；化合物 FBPase-IN-2FBPase-IN-2
FBPase-IN-2 (HS36), a potent covalent inhibitor of Fructose-1,6-bisphosphatase (FBPase), exhibits an IC50 of 0.15 μM and effectively reduces glucose production in hepatocytes, making it relevant for type 2 diabetes mellitus research [1].
价 格：￥电议型 号：T60294产 地：中国大陆
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T60286DHFR-IN-2；化合物 DHFR-IN-2DHFR-IN-2
DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor for MtDHFR with an IC 50 of 7 μM. The enzyme dihydrofolate reductase from M.tuberculosis (MtDHFR) has a high unexploited potential to be a target for new drugs against tuberculosis (TB), due to its importance for pathogen survival. DHFR-IN-2 can be used for tuberculosis (TB) research [1].
价 格：￥电议型 号：T60286产 地：中国大陆
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T60278Tyrosinase-IN-2；化合物Tyrosinase-IN-2Tyrosinase-IN-2
Tyrosinase-IN-2 (compound 67) is a potent inhibitor of tyrosinase, a copper-containing metalloenzyme pivotal for the catalytic step that limits the rate in melanin biosynthesis and enzymatic browning processes. This compound holds potential for research into skin whitening agents and food preservatives [1].
价 格：￥电议型 号：T60278产 地：中国大陆
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T60275ALDH3A1-IN-2；化合物 ALDH3A1-IN-2ALDH3A1-IN-2
ALDH3A1-IN-2 (Compound 19), a potent inhibitor of aldehyde dehydrogenases (ALDHs), demonstrates high efficacy against ALDH3A1 with an IC50 of 1.29 μM. Given the overexpression of ALDHs in multiple tumor types, including prostate cancer, ALDH3A1-IN-2 holds significant potential for cancer research [1].
价 格：￥电议型 号：T60275产 地：中国大陆
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T60271SARS-CoV-2 nsp3-IN-2；化合物 SARS-CoV-2 nsp3-IN-2SARS-CoV-2 nsp3-IN-2
SARS-CoV-2 nsp3-IN-2 is a SARS-CoV-2 nsp3 macrodomain (Mac1) inhibitor with IC 50 value of 180 μM. SARS-CoV-2 nsp3 macrodomain is an ADP-ribosylhydrolase that is critical for coronavirus replication and pathogenesis. SARS-CoV-2 nsp3-IN-2 is a small molecule chemical probe that can be used for the viral research[1].
价 格：￥电议型 号：T60271产 地：中国大陆
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T60240ALDH1A3-IN-2；化合物ALDH1A3-IN-2ALDH1A3-IN-2
ALDH1A3-IN-2 is a potent ALDH1A3 inhibitor with an IC50 of 0.30 μM.ALDH1A3-IN-2 has potential for cancer disease research.
价 格：￥电议型 号：T60240产 地：中国大陆
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T60202MMRi62；化合物T602027-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol；7-[(2,3-dichlorophen
MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits ortho
价 格：￥电议型 号：T60202产 地：中国大陆
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T60156PBRM1-BD2-IN-2；化合物PBRM1-BD2-IN-2PBRM1-BD2-IN-2
PBRM1-BD2-IN-2, a selective and cell-active inhibitor of the polybromo-1 (PBRM1) bromodomain, exhibits binding affinity and inhibitory activity specifically targeting the PBRM1-BD2 domain, with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. This compound is utilized in cancer research.
价 格：￥电议型 号：T60156产 地：中国大陆
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T60098MSC2504877；化合物MSC25048773-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one；3
MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phospho-Rb.
价 格：￥电议型 号：T60098产 地：中国大陆
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T60094SU 4981；3-(4-吗啉亚苄基)吲哚啉-2-酮3-(4-Morpholinobenzylidene)indolin-2-one；3-(4-Morpholinobenzylidene)indoli
SU 4981 is an inhibitor of VEGFR and a modulator of tyrosine kinase activity.
价 格：￥电议型 号：T60094产 地：中国大陆
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T60086TTBK1-IN-2；化合物TTBK1-IN-2N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine；N-[4-(4-chl
TTBK1-IN-2 (N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine) is an inhibitor of Tau-Tubulin kinase (TTBK1) with IC50s of 0.24 and 4.22 ?M. TTBK1-IN-2 reduces TDP-43 phosphorylation both in cell cultures and the spinal cord of transgenic TDP-43 mice.
价 格：￥电议型 号：T60086产 地：中国大陆
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T60060ACSS2-IN-2；化合物ACSS2-IN-2MTB-9655；MTB-9655
ACSS2-IN-2 (MTB-9655) is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer.
价 格：￥电议型 号：T60060产 地：中国大陆
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T60059methyl (Z)-4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropen
methyl(Z)-4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzoate is a useful compound for the synthesis of a variety of organic compounds.
价 格：￥电议型 号：T60059产 地：中国大陆
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T60058methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-
methyl4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-yn-2-yl)oxy)benzoate is a useful compound for the synthesis of a variety of organic compounds.
价 格：￥电议型 号：T60058产 地：中国大陆
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T60035(S)-5-chloro-N-(1-((4-chlorophenyl)amino)-1-oxo-3-phenylpropan-2-yl)-2-hydroxybenzamide；化合物 T60035(S
(S)-5-chloro-N-(1-((4-chlorophenyl)amino)-1-oxo-3-phenylpropan-2-yl)-2-hydroxybenzamide has antifungal and tuberculostatic activities.
价 格：￥电议型 号：T60035产 地：中国大陆
