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  • T80259PMAP-23；化合物 PMAP-23PMAP-23

    PMAP-23 is an antimicrobial peptide (AMP) with biological activity, derived from porcine myeloid cells.

    价 格：￥电议型 号：T80259产 地：中国大陆

  • T80252BMAP-18；化合物 BMAP-18BMAP-18

    BMAP-18 is a biologically active peptide, a truncated derivative of BMAP-27, which is part of the Cathelicidin family of peptides known for their potent bactericidal properties against pathogens such as Staphylococcus aureus, Streptococcus uberis, and Escherichia coli. Unlike the full-length BMAP-27, which can be cytotoxic to human erythrocytes and neutrophils at concentrations higher than required for its antimicrobial effect, BMAP-18 offers increased cell selectivity due to its reduced hemolyt

    价 格：￥电议型 号：T80252产 地：中国大陆

  • T80215BMAP-28；化合物 BMAP-28BMAP-28

    BMAP-28, an antibiotic peptide, induces cell death by triggering the mitochondrial permeability transition pore and serves as a research tool in the study of microbial infections and cancer [1].

    价 格：￥电议型 号：T80215产 地：中国大陆

  • T80213BMAP-27；化合物 BMAP-27BMAP-27

    BMAP-27, an antimicrobial peptide, disrupts the membrane integrity of microorganisms, exhibiting inhibitory activity against bacteria and cancer cells due to its membrane permeability [1].

    价 格：￥电议型 号：T80213产 地：中国大陆

  • T80171Tamapin TFA；化合物 Tamapin TFATamapin TFA

    Tamapin TFA, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small conductance Ca(2+)-activated K(+) (SK) channels, particularly the SK2 subtype (Potassium Channel). It is known to inhibit SK channel-mediated currents in the hippocampal pyramidal neurons.

    价 格：￥电议型 号：T80171产 地：中国大陆

  • T80170Tamapin；化合物 TamapinTamapin

    Tamapin, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small-conductance Ca(2+)-activated K(+) (SK) channels, particularily SK2 (Potassium Channel). It inhibits SK channel-mediated currents in the pyramidal neurons of the hippocampus.

    价 格：￥电议型 号：T80170产 地：中国大陆

  • T80062Mitogen-activated protein kinase 1；化合物 Mitogen-activated protein kinase 1MAPK1；MAPK1

    Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases. Its catalytic action phosphorylates substrate proteins, serving as a regulatory switch for their activity [1].

    价 格：￥电议型 号：T80062产 地：中国大陆

  • T79794TNIK&MAP4K4-IN-1；化合物 TNIK&MAP4K4-IN-1TNIK&MAP4K4-IN-1

    TNIK&MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor targeting TNIK and MAP4K4/HGK, exhibiting IC50 values of 1.29 nM and <10 nM, respectively, in human hepatic stellate cell LX-2. This compound is applicable in the inhibition of cancer and fibrosis [1].

    价 格：￥电议型 号：T79794产 地：中国大陆

  • T79572MAPK-IN-2；化合物 MAPK-IN-2MAPK-IN-2

    MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cell lines. It demonstrates robust suppression of the MAPK pathway (EGFR WT IC50 = 281 nM, c-MET IC50 = 205 nM, B-RAF WT IC50 = 112 nM, CDK4/6 IC50 = 95 and 184 nM, respectively) and exhibits pronounced activity against mutated forms of EGFR and B-RAF (EGFR T790M IC50 = 69 nM and B-RAF V600E IC50 = 83 nM) [1].

    价 格：￥电议型 号：T79572产 地：中国大陆

  • T79304Semapimod；化合物 SemapimodCPSI-2364|||CNI-1493 free base；CPSI-2364|||CNI-1493 free base

    Semapimod is an inhibitor of proinflammatory cytokine production, capable of suppressing TNF-α, IL-1β, and IL-6. It hinders TLR4 signaling with an IC50 of approximately 0.3 μM, impedes p38 MAPK, and reduces nitric oxide production in macrophages. This compound shows promise for treating various inflammatory and autoimmune disorders [1] [2] [3].

    价 格：￥电议型 号：T79304产 地：中国大陆

  • T78838Akt/NF-κB/MAPK-IN-1；化合物 Akt/NF-κB/MAPK-IN-1Akt/NF-κB/MAPK-IN-1

    Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity. This compound exerts anti-inflammatory effects by impeding the Akt/NF-κB and MAPK signaling pathways [1].

    价 格：￥电议型 号：T78838产 地：中国大陆

  • T77780Zamaporvint；化合物ZamaporvintRXC004；RXC004

    Zamaporvint (RXC004) is a selective, orally active and potent inhibitor of the Wnt pathway that acts on the membrane-bound fatty acyltransferase porcupine to block Wnt ligand palmitoylation, secretion, and pathway activation.Zamaporvint has shown anti-tumor and anti-proliferative activity in a wide range of cancer cell lines.

    价 格：￥电议型 号：T77780产 地：中国大陆

  • T77751Imaprelimab；伊普利单抗PRX-003；PRX-003

    Imaprelimab (PRX-003) is a humanized IgG1 κmonoclonal antibody against melanoma cell adhesion molecule (MCAM). Imaprelimab has antitumor activity and can be used to study inflammation, tumors, and psoriasis.

    价 格：￥电议型 号：T77751产 地：中国大陆

  • T76742Emapalumab；依马利尤单抗NI-0501；NI-0501

    Emapalumab (NI-0501) is an IgG1 monoclonal antibody that humanizes human monoclonal antibodies against interferon gamma, blocking its binding to cell surface receptors and activating inflammatory signaling. Emapalumab has a high binding force (Kd=1.4 pM) to free IFN-γ and to IFN-γ bound to its receptor. Emapalumab can be used in the study of hemophagocytic lymphohistiocytosis (HLH).

    价 格：￥电议型 号：T76742产 地：中国大陆

  • T74691Aprinocarsen sodium；化合物 Aprinocarsen sodiumAprinocarsen sodium

    Aprinocarsen (ISIS 3521) sodium is a specific antisense oligonucleotide inhibitor targeting protein kinase C-alpha (PKC-α). It is a 20-mer oligonucleotide that modulates cell differentiation and proliferation. Demonstrating efficacy in inhibiting the growth of human tumor cell lines in nude mice, Aprinocarsen sodium presents significant chemotherapeutic potential against human cancers [1].

    价 格：￥电议型 号：T74691产 地：中国大陆

  • T74433Apatorsen sodium；化合物 Apatorsen sodiumApatorsen sodium

    Apatorsen (sodium) is an antisense oligonucleotide that targets Hsp27 mRNA, effectively inhibiting the production of Hsp27 protein.

    价 格：￥电议型 号：T74433产 地：中国大陆

  • T73992IONIS-MAPTRx；化合物 IONIS-MAPTRxIONIS-MAPTRx

    IONIS-MAPTRx (BIIB080) is the first Tau-lowering antisense oligonucleotide (ASO). IONIS-MAPTRx has the potential for the research of Alzheimer Disease [1] . ( MCE IONIS-MAPTRx for murine use [3] : Tau ASO-12 sequence – 5′ GCTTTTACTGACCATGCGAG 3′ )

    价 格：￥电议型 号：T73992产 地：中国大陆

  • T7367Acumapimod；化合物AcumapimodBCT-197；BCT-197

    Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).

    价 格：￥电议型 号：T7367产 地：中国大陆

  • T71928Nordimaprit dihydrochloride；化合物 Nordimaprit dihydrochlorideNordimaprit dihydrochloride

    Nordimaprit dihydrochloride is a metabolite of Dimaprit -- a histamine analog and selective H2 histamine receptor agonist.

    价 格：￥电议型 号：T71928产 地：中国大陆

  • T71058Doramapimod HCl；化合物 Doramapimod HClDoramapimod HCl

    Doramapimod HCl is the salt form of Doramapimod, a member of the N-pyrazole-N´-naphthly urea class of p38MAPK inhibitors, which binds to the kinase with both slow association and dissociation rates. BIRB -796 has entered clinical trials for the treatment of autoimmune diseases.

    价 格：￥电议型 号：T71058产 地：中国大陆

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