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  • T72330Antibacterial agent 19；化合物 Antibacterial agent 19Antibacterial agent 19

    Antibacterial agent 19 exhibits strong activity against K. pneumoniae, (M-R) S. aureus, and (M-R,V-R) S. aureus, demonstrating minimum inhibitory concentrations (MICs) of 0.022 mg/mL for both K. pneumoniae and (M-R) S. aureus, and 0.045 mg/mL for (M-R,V-R) S. aureus.

    价 格：￥电议型 号：T72330产 地：中国大陆

  • T72267Antitrypanosomal agent 9；化合物 Antitrypanosomal agent 9Antitrypanosomal agent 9

    Antitrypanosomal agent 9 is a potent compound with inhibitory activity against T. b. brucei, exhibiting an IC50 of 1.15 μM. It is utilized in research for human African trypanosomiasis (HAT).

    价 格：￥电议型 号：T72267产 地：中国大陆

  • T72205Antiproliferative agent-19；化合物 Antiproliferative agent-19Antiproliferative agent-19

    Antiproliferative Agent-19, an anti-cancer compound, demonstrates antiproliferative effects by inducing apoptosis in lung cancer cells and causing cell cycle arrest in the G2/M phase.

    价 格：￥电议型 号：T72205产 地：中国大陆

  • T7197LFadrozole HCl hydrate；化合物 T7197LFadrozole|||CGS-16949A|||Fadrozole hydrochloride hemihydrate|||CGS16

    Fadrozole is a selective inhibitor of aromatase. It also effective in the treatment of estrogen-dependent diseases including breast cancer.

    价 格：￥电议型 号：T7197L产 地：中国大陆

  • T71924LAC 7739；化合物 AC 7739AC 7739

    AC 7739 is a microtubule protein binding agent with anticancer and antitumor activity that inhibits advanced solid tumors and in situ transplanted tumors.

    价 格：￥电议型 号：T71924L产 地：中国大陆

  • T71854AA43279；化合物 AA43279AA43279

    AA43279 is a novel selective Nav1.1 activator, increasing the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increasing the spontaneous inhibitory post-synaptic currents (sIPSCs) recorded from pyramidal neurons.

    价 格：￥电议型 号：T71854产 地：中国大陆

  • T71839ATV399；化合物 ATV399ATV399

    ATV399 is an inhibitor of iNOS dimerization which protects against Cytokine-Induced rat β-cell dysfunction, thereby inhibiting cleaved caspase-9 activation and subsequent β-cell apoptosis induced by a combination of IL-1β, IFN-γ, and high glucose.

    价 格：￥电议型 号：T71839产 地：中国大陆

  • T71754AV-9606-129；化合物 AV-9606-129AV-9606-129

    AV-9606-129" is a USP28 inhibitor"

    价 格：￥电议型 号：T71754产 地：中国大陆

  • T71651GSK1370319A；化合物 GSK1370319AGSK1370319A

    GSK1370319A is a potent P2X7 antagonist (IC50 = 3.2 nM). GSK1370319A inhibits ATP-induced increase in IL-1β release and caspase 1 activation in lipopolysaccharide (LPS)-primed mixed glia by blocking assembly of the inflammasome in a pannexin 1-dependent manner. GSK1370319A also inhibits ATP-induced subregion-specific neuronal loss in hippocampal organotypic slice cultures, which is dependent on its ability to prevent inflammasome assembly in glia. Significantly, GSK1370319A attenuates age-relate

    价 格：￥电议型 号：T71651产 地：中国大陆

  • T71363ACT-281959；化合物 ACT-281959ACT-281959

    ACT-281959, a prodrug of ACT-246475, is a novel potent and selective P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel. ACT-281959 showed antithrombotic efficacy after oral administration in the rat ferric chloride model. ACT-281959 entered clinical studies in healthy volunteers.

    价 格：￥电议型 号：T71363产 地：中国大陆

  • T70733APX2009；化合物 APX2009APX2009

    APX2009 is a second-generation APE1/Ref-1 redox-specific inhibitor. APX2009 significantly reduces NFkB transcriptional activity, survivin mRNA, and survivin protein levels. APX2009 decreases prostate cancer cell proliferation and induces cell cycle arrest.

    价 格：￥电议型 号：T70733产 地：中国大陆

  • T70440AGN-191659；化合物 AGN-191659AGN-191659

    AGN-191659 is a Retinoid X Receptor (RXR) pan-agonist. RXR pan-agonists have been shown to modulate endothelial cell proliferation.

    价 格：￥电议型 号：T70440产 地：中国大陆

  • T70373AS2575959；化合物 AS2575959AS2575959

    AS2575959 is a novel GPR40 agonist, exhibiting glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion.

    价 格：￥电议型 号：T70373产 地：中国大陆

  • T70004APS-2-79；化合物 APS-2-79APS-2-79

    APS-2-79, a KSR-dependent MEK antagonist, disrupts ATP (biotin) binding within the KSR2-MEK1 complex, achieving an inhibitory concentration (IC50) of 120 nM. This action stabilizes the KSR inactive state and antagonizes oncogenic Ras-MAPK signaling.

    价 格：￥电议型 号：T70004产 地：中国大陆

  • T69912AS2541019；化合物 AS2541019AS2541019

    AS2541019 is a selective Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibitor.

    价 格：￥电议型 号：T69912产 地：中国大陆

  • T69403AZD-3409；化合物 AZD-3409AZD-3409

    AZD-3409 is a potent prenyl transferase inhibitor. AZD-3409 showed higher potency than lonafarnib. The mean IC(50) for cytotoxicity of AZD3409 was 510 in MEF cells, 10,600 in A549 cells and 6,170 in MCF7 cells, respectively. In these cells, the IC(50) for FTase activity of AZD3409 ranged from 3.0 to 14.2 nM and of lonafarnib from 0.26 to 31.3 nM. AZD3409 inhibits farnesylation to a higher extent than geranylgeranylation. Both inhibition of farnesylation and geranylgeranylation could not be corre

    价 格：￥电议型 号：T69403产 地：中国大陆

  • T69135AGN-2979；化合物 AGN-2979AGN-2979

    AGN-2979 is a tryptophan hydroxylase (TPH) activation inhibitor that shows antidepressant properties in rodent models of depression.

    价 格：￥电议型 号：T69135产 地：中国大陆

  • T68996AQ 1989；化合物 AQ 1989AQ 1989

    AQ 1989 is a platelet aggregation inhibitor.

    价 格：￥电议型 号：T68996产 地：中国大陆

  • T68438APO-6619；化合物 APO-6619APO-6619

    APO-6619 is an iron chelator which was shown to inhibit growth of the following bacterial strains: Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. APO-6619 may be useful as a non-traditional treatment of bacterial infections.

    价 格：￥电议型 号：T68438产 地：中国大陆

  • T68406A-849519；化合物 A-849519A-849519

    A-849519 is a reversible inhibitor of MetAP2 that has demonstrated anti-angiogenesis and anticancer activity in a number of in vitro and in vivo models. In this study, we evaluated the anticancer activity of A-849519 in a modified Dunning model of androgen-independent prostate cancer and compared its efficacy with TNP-470, an established MetAP2 inhibitor.

    价 格：￥电议型 号：T68406产 地：中国大陆

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