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  • T61198FAAH/MAGL-IN-1;化合物 FAAH/MAGL-IN-1FAAH/MAGL-IN-1

    FAAH/MAGL-IN-1, also known as compound SIH 3, is a highly effective inhibitor of FAAH (fatty acid amide hydrolase) and MAGL (monoacylglycerol lipase). It exhibits IC50 values of 31 nM and 29 nM against FAAH and MAGL, respectively. This compound shows promising potential for advancing research in the field of neuropathic pain [1].

    价 格:¥电议型 号:T61198产 地:中国大陆

  • T61197Irdabisant hydrochloride;化合物 Irdabisant hydrochlorideIrdabisant hydrochloride

    Irdabisant hydrochloride (CEP-26401) is a selective, orally active, and blood-brain barrier (BBB) penetrant histamine H3 receptor (H3R) inverse agonist/inverse agonist, demonstrating high affinity with K*i values of 7.2 nM and 2.0 nM for rat and human H3R respectively. It exhibits relatively low hERG current inhibitory activity, with an IC*50 of 13.8 μM. This compound has been shown to enhance cognition and promote wakefulness in rat social recognition models, suggesting potential applications i

    价 格:¥电议型 号:T61197产 地:中国大陆

  • T61196COX-1/2-IN-1;化合物 COX-1/2-IN-1COX-1/2-IN-1

    COX-1/2-IN-2, a potent inhibitor of both COX-1 and COX-2, demonstrates significant inhibitory activity, with IC50 values of 13.9 ± 3.21 μM for COX-1 and 6.4 ± 0.74 μM for COX-2, respectively [1].

    价 格:¥电议型 号:T61196产 地:中国大陆

  • T61193DDX3-IN-2;化合物 DDX3-IN-2DDX3-IN-2

    DDX3-IN-2, a potent inhibitor of DEADbox polypeptide 3 (DDX3), demonstrates remarkable activity against the target with an IC50 value of 0.3 μM. Notably, this compound exhibits a wide range of antiviral effects, showcasing its efficacy against various viral strains. Importantly, DDX3-IN-2 exhibits the potential to overcome resistance observed in the context of HIV [1].

    价 格:¥电议型 号:T61193产 地:中国大陆

  • T61192CBR-6672;化合物 CBR-6672CBR-6672

    CBR-6672, a type II NADH dehydrogenase inhibitor, demonstrates potent antimycobacterial activity against mycobacterium tuberculosis (Mtb) with a minimum inhibitory concentration (MIC) of 0.14 μM [1].

    价 格:¥电议型 号:T61192产 地:中国大陆

  • T61191EAI001;化合物EAI001EAI001

    EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI001 can be used in cancer research.

    价 格:¥电议型 号:T61191产 地:中国大陆

  • T61190Tubulin inhibitor 27;化合物 Tubulin inhibitor 27Tubulin inhibitor 27

    Tubulin Inhibitor 27 (DYT-1), a compound that inhibits tubulin polymerization with an IC50 of 25.6 μM, exhibits anti-angiogenesis and antitumor activities [1].

    价 格:¥电议型 号:T61190产 地:中国大陆

  • T6119Sotuletinib;化合物BLZ945BLZ945;BLZ945

    Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor (IC50: 1 nM), >1000-fold selective against its closest receptor tyrosine kinase homologs.

    价 格:¥电议型 号:T6119产 地:中国大陆

  • T61189E7016;化合物E7016GPI 21016;GPI 21016

    E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.

    价 格:¥电议型 号:T61189产 地:中国大陆

  • T61188Chitin synthase inhibitor 2;化合物 Chitin synthase inhibitor 2Chitin synthase inhibitor 2

    Chitin synthase inhibitor 2 (compound 2b) is a highly potent inhibitor of chitin synthase, with an IC50 value of 0.09 mM and a K i value of 0.12 mM. This compound exhibits antimicrobial activities in vitro and demonstrates synergistic or additive effects when combined with fluconazole or polyoxin B [1].

    价 格:¥电议型 号:T61188产 地:中国大陆

  • T61187BRD4 Inhibitor-17;化合物 BRD4 Inhibitor-17BRD4 Inhibitor-17

    BRD4 Inhibitor-17 (Compound 5i) is a highly potent inhibitor of BRD4, exhibiting an impressive IC50 value of 0.33 μM. It fulfills a crucial regulatory function in transcription by effectively modulating the expression of inflammatory, proliferation, and cell cycle genes. Moreover, BRD4 Inhibitor-17 shows promise as a potential remedy for arsenical-induced toxicity, thus highlighting its potential as an antidote in such cases [1].

    价 格:¥电议型 号:T61187产 地:中国大陆

  • T61186Antitumor agent-57;化合物 Antitumor agent-57Antitumor agent-57

    Antitumor agent-57 (Compound 3o) is a potent NQO1-directed antitumor compound. It effectively inhibits tumor cell growth, induces ROS generation, and promotes cell apoptosis [1].

    价 格:¥电议型 号:T61186产 地:中国大陆

  • T61184LQZ-7F;化合物 LQZ-7FLQZ-7F

    LQZ-7F is a small molecule survivin dimerisation inhibitor with anticancer activity.LQZ-7F induces proteasome-dependent survivin degradation, mitotic arrest, and apoptosis, and blocks human tumour growth in mouse xenograft assays.

    价 格:¥电议型 号:T61184产 地:中国大陆

  • T61183MRGPRX4 modulator-2;化合物 MRGPRX4 modulator-2MRGPRX4 modulator-2

    MRGPRX4 modulator-2 (compound 1-55) is a highly potent modulator of MRGPR X4, displaying antagonist activity against this receptor with an IC50 value of less than 100 nM. Its application in the research of autoimmune diseases such as psoriasis, multiple sclerosis, Steven Johnson´s Syndrome, and various chronic itch conditions is notable [1].

    价 格:¥电议型 号:T61183产 地:中国大陆

  • T61182(R)-BDP9066;化合物 (R)-BDP9066(R)-BDP9066

    (R)-BDP9066 is a highly effective inhibitor of myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK), effectively impeding cancer cell invasion, making it an invaluable resource for studying and researching proliferative diseases, particularly cancer.

    价 格:¥电议型 号:T61182产 地:中国大陆

  • T61181Pentagamavunon-1;化合物 Pentagamavunon-1Pentagamavunon-1

    Pentagamavunon-1 (PGV-1) is an oral Curcumin analog that effectively induces apoptosis through multiple molecular mechanisms. It primarily targets and inhibits key angiogenic factors, including cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF), which play crucial roles in mediating cell proliferation and survival. Additionally, PGV-1 possesses the ability to inhibit the activation of NF-κB, further enhancing its apoptotic effects. [1]

    价 格:¥电议型 号:T61181产 地:中国大陆

  • T61180GAT564;化合物 GAT564GAT564

    GAT564 (Compound 15d) is a highly effective allosteric modulator of cannabinoid 1 receptor (CB1R), having EC50 values of 87 nM and 320 nM for cAMP and β-arrestin2, respectively. It significantly enhances the binding of orthosteric ligands to hCB1R. Moreover, GAT564 exhibits remarkable efficacy as a topical agent, resulting in a significant reduction of intraocular pressure (IOP) in an ocular normotensive murine model of glaucoma [1].

    价 格:¥电议型 号:T61180产 地:中国大陆

  • T6118NVP-HSP990;化合物HSP990HSP990;HSP990

    NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).

    价 格:¥电议型 号:T6118产 地:中国大陆

  • T61179EMI48;化合物 EMI48EMI48

    EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].

    价 格:¥电议型 号:T61179产 地:中国大陆

  • T61178Aβ-IN-5;化合物 Aβ-IN-5Aβ-IN-5

    Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor that also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Furthermore, Aβ-IN-5 exhibits remarkable neuroprotective effects along with low neurotoxicity [1].

    价 格:¥电议型 号:T61178产 地:中国大陆

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