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T71085BMS-824；化合物 BMS-824BMS-824
BMS-824 is a potent NS5A inhibitor. The 50% inhibition of HCV replicon replication for BMS-824 was approximately 5 nM, with a therapeutic index of >10,000. BMS-824 showed good specificity for HCV, as it was not active against several other RNA and DNA viruses.
价 格：￥电议型 号：T71085产 地：中国大陆
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T70864BMS-883559；化合物 BMS-883559BMS-883559
BMS-883559 is a novel inhibitor of the influenza nucleoprotein (INF-NP).
价 格：￥电议型 号：T70864产 地：中国大陆
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T70847BMS-351；化合物 BMS-351BMS-351
BMS-351 is a potent and selective, nonsteroidal CYP17A1 lyase inhibitor with robust selectivity over steroidogenic CYPs 21A2 and 11B1. BMS-351 emerges as an outstanding preclinical candidate to treat CRPC and is likely to minimize the side effects of current therapies due to its exceptional selectivity. BMS-351 is potentially useful for the Treatment of Prostate Cancer.
价 格：￥电议型 号：T70847产 地：中国大陆
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T70680BMS-961955；化合物 BMS-961955BMS-961955
BMS-961955 is an allosteric inhibitor of the hepatitis C virus NS5B polymerase.
价 格：￥电议型 号：T70680产 地：中国大陆
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T70450BMS-870145；化合物 BMS-870145BMS-870145
BMS-870145 is a potent and selective P2Y1 purinergic receptor antagonist..
价 格：￥电议型 号：T70450产 地：中国大陆
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T70436BMS 188745 Potassium Salt；化合物 BMS 188745 Potassium SaltBMS 188745 Potassium Salt
BMS 188745 Potassium Salt inhibits the biosynthesis of the Staphylococcus aureus virulence factor staphyloxanthin via inhibition of dehydrosqualene synthase (CrtM).
价 格：￥电议型 号：T70436产 地：中国大陆
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T70435BMS-187745；化合物 BMS-187745BMS-187745
BMS-187745 is a squalene synthase inhibitor.
价 格：￥电议型 号：T70435产 地：中国大陆
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T70389BMS986126；化合物 BMS986126BMS986126
BMS-986122 is a IRAK4 Inhibitor. BMS-986126 attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. BMS-986126 inhibited TLR7- and TLR9-dependent responses using cells derived from lupus patients, suggesting that inhibition of IRAK4 has the potential for therapeutic benefit in treating lupus.
价 格：￥电议型 号：T70389产 地：中国大陆
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T70287BMS-186511；化合物 BMS-186511BMS-186511
BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from malignant schwannoma of an NF1 patient. Following treatment with BMS-186511 , ST88-14 cells became flat, nonrefractile, were contact-inhibited, and lost their ability to grow in soft agar. BMS-186511 was found to specifically inhibit FT, but not geranylgeranyltransferase I, a clos
价 格：￥电议型 号：T70287产 地：中国大陆
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T70286BMS-37；化合物 BMS-37BMS-37
BMS-37 is a novel inhibitor of PD-1/PD-L1 immune checkpoint.
价 格：￥电议型 号：T70286产 地：中国大陆
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T70285BMS-200；化合物 BMS-200BMS-200
BMS-200 is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 80 nM.
价 格：￥电议型 号：T70285产 地：中国大陆
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T69986BMS-955176 HCl；化合物 BMS-955176 HClBMS-955176 HCl
GSK-3532795 is a second generation inhibitor of hiv-1 maturation, exhibiting a broader spectrum of antiviral effect in vitro and in clinical studies than the prototypical maturation inhibitor bevirimat
价 格：￥电议型 号：T69986产 地：中国大陆
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T69770BMS-986313；化合物 BMS-986313BMS-986313
BMS-986313 is a RORγt Inverse Agonist with RORγt EC50 = 3.6 nM and WB EC50 = 50 nM.
价 格：￥电议型 号：T69770产 地：中国大陆
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T69686BMS-986318；化合物 BMS-986318BMS-986318
BMS-986318 is a potent nonbile acid FXR agonist, displaying EC50 values of 53 nM and 350 nM in FXR Gal4 and SRC-1 recruitment assays, respectively. It exhibits a favorable ADME profile and shows effectiveness in mouse models of liver cholestasis and fibrosis caused by bile duct ligation. BMS-986318 is employed in research focusing on nonalcoholic steatohepatitis.
价 格：￥电议型 号：T69686产 地：中国大陆
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T69523BMS-681；化合物 BMS-681BMS-681
BMS-681 is an orthosteric antagonist of chemokine receptor 2 (CCR2) that forms a ternary complex with CCR2 and its allosteric antagonist, CCR2-RA-[R]. Together, the complex inhibits chemokine binding with BVMS-681 in the orthosteric pocket and CCR2-RA-[R] in the intracellular allosteric G-protein binding site. When chemokine binding is inhibited, modulation responses implicated in several inflammatory and neurodegenerative diseases, including atherosclerosis, multiple sclerosis, asthma, neuropat
价 格：￥电议型 号：T69523产 地：中国大陆
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T69371BMS 378806；化合物 BMS 378806BMS 378806
BMS-378806 is an orally bioavailable HIV-1 inhibitor that interferes with gp120-CD4 interaction.
价 格：￥电议型 号：T69371产 地：中国大陆
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T69221BMS-554417；化合物 BMS-554417BMS-554417
BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, and reduces tumor xenograft size in vivo. In a series of carcinoma cell lines, the IC50 for proliferation ranged from 120 nmol/L (Colo205) to >8.5 micromol/L (OV202). BMS-554417 treatment inhibited IGF-IR and insulin receptor signaling through extracellular signal-related kinase as well as the phosphoinositide 3-kinase/Akt pathway, as evidenced by decreased Akt phosph
价 格：￥电议型 号：T69221产 地：中国大陆
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T69181BMS-566394；化合物 BMS-566394BMS-566394
BMS-566394 is a potent, exceptionally selective inhibitor of TNF-α converting enzyme (TACE).
价 格：￥电议型 号：T69181产 地：中国大陆
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T68935BMS-645737；化合物 BMS-645737BMS-645737
BMS-645737 is an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1. BMS-646737 has anti-angiogenic activity and was evaluated in nonclinical studies as a treatment for cancer.
价 格：￥电议型 号：T68935产 地：中国大陆
