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  • T62044Anticancer agent 71；化合物 Anticancer agent 71Anticancer agent 71

    Anticancer agent 71 (Compound 4b) is a potent anticancer agent. Anticancer agent 71 arrests cell cycle at G2/M phase. Anticancer agent 71 induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels.

    价 格：￥电议型 号：T62044产 地：中国大陆

  • T62043Dyrk1A/B-IN-1；化合物 Dyrk1A/B-IN-1Dyrk1A/B-IN-1

    Dyrk1A/B-IN-1 (compound 3n) is a potent, selective and cell-permeable inhibitor of DYRK1A and DYRK1B. Dyrk1A/B-IN-1 inhibits DYRK1A and DYRK1B with Kis of 67.8 nM and 237.9 nM, and IC 50 s of 1.1 μM and 0.8 μM, respectively.

    价 格：￥电议型 号：T62043产 地：中国大陆

  • T61882AT791；化合物 AT791AT791

    AT791 is an effective TLR7 and TLR9 inhibitor with oral activity. AT791 has inhibitory effects on TLR7 and TLR9 signal transduction in various types of human and mouse cells. AT791 inhibits DNA-TLR9 interaction in vitro.

    价 格：￥电议型 号：T61882产 地：中国大陆

  • T61855Antistaphylococcal agent 1；化合物 Antistaphylococcal agent 1Antistaphylococcal agent 1

    Antistaphylococcal agent 1 is an antistaphylococcal therapeutic agent.

    价 格：￥电议型 号：T61855产 地：中国大陆

  • T61853Antimycobacterial agent-1；化合物 Antimycobacterial agent-1Antimycobacterial agent-1

    Antimycobacterial agent-1 (compound 33) demonstrates potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra, with a minimal inhibitory concentration (MIC) value of 1 μg/ml. Notably, antimycobacterial agent-1 exhibits low cytotoxicity in normal cells, as evidenced by an IC50 value of 143.2 μg/ml in Vero cells [1].

    价 格：￥电议型 号：T61853产 地：中国大陆

  • T61850Adenosine receptor inhibitor 1；化合物 Adenosine receptor inhibitor 1Adenosine receptor inhibitor 1

    Adenosine receptor inhibitor 1 is a highly potent and selective antagonist of adenosine receptor (AR). It exhibits exceptional affinity for A1 AR, A2A AR, A2B AR, and A3 AR, with respective Ki values of >1000, 68.5, >1000, >1000 nM. This compound demonstrates notable antinociceptive, anti-inflammatory, and peripheral analgesic properties. Therefore, Adenosine receptor inhibitor 1 holds great promise for investigating cancer and neurodegenerative diseases [1].

    价 格：￥电议型 号：T61850产 地：中国大陆

  • T61845AChE-IN-21；化合物 AChE-IN-21AChE-IN-21

    AChE-IN-21 (Compound I-8) is a highly potent and selective orally active inhibitor of acetylcholinesterase (AChE). It exhibits an impressive inhibitory concentration (IC50) of 2.66 nM. Additionally, AChE-IN-21 demonstrates excellent in vitro blood-brain barrier (BBB) permeability [1].

    价 格：￥电议型 号：T61845产 地：中国大陆

  • T61820Ar-V7-IN-1；化合物 Ar-V7-IN-1Ar-V7-IN-1

    Ar-V7-IN-1 is a highly potent inhibitor specifically targeting Ar-V7, a splice variant of the androgen receptor that exhibits hormone-independent behavior. Its development shows promise for researching various indications, notably cancers such as prostate cancer[1].

    价 格：￥电议型 号：T61820产 地：中国大陆

  • T61783Antimicrobial agent-1；化合物 Antimicrobial agent-1Antimicrobial agent-1

    Antimicrobial Agent-1 (compound 6C) shows strong activity (MIC = 2 μg/mL) against TolC mutant E. coli. Additionally, it synergistically interacts with Colistin to exhibit enhanced activity against Gram-negative bacteria. Importantly, Antimicrobial Agent-1 exhibits no cytotoxic effects on mammalian cell lines. Its MIC values on Caco-2 and Vero cell lines are greater than 128 μg/mL [1].

    价 格：￥电议型 号：T61783产 地：中国大陆

  • T61756APN/AKT-IN-1；化合物 APN/AKT-IN-1APN/AKT-IN-1

    APN/AKT-IN-1 is a potent dual inhibitor of aminopeptidase N (APN) and protein kinase B (AKT), exhibiting IC50 values of 0.21 μM and 0.27 μM for APN and AKT inhibition, respectively. This compound effectively suppresses the phosphorylation of glycogen synthase kinase 3 beta (GSK3β), which serves as an intracellular substrate of AKT [1].

    价 格：￥电议型 号：T61756产 地：中国大陆

  • T61739Dyrk1A-IN-5；化合物 Dyrk1A-IN-5Dyrk1A-IN-5

    Dyrk1A-IN-5 (compound 5j) is a highly potent and selective inhibitor of DYRK1A, exhibiting an IC50 of 6 nM. It dose-dependently diminishes the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Moreover, Dyrk1A-IN-5 effectively inhibits the phosphorylation of tau at Thr212, with an IC50 of 2.1 μM. Given these properties, Dyrk1A-IN-5 is a valuable tool for Down syndrome research [1].

    价 格：￥电议型 号：T61739产 地：中国大陆

  • T61620AChE/PDE4-IN-1；化合物 AChE/PDE4-IN-1AChE/PDE4-IN-1

    AChE/PDE4-IN-1 (compound 12c) is a highly effective and specific dual inhibitor of PDE4 and AChE, with IC50 values of 0.28 μM and 1.88 μM for AChE and PDE4D, respectively. This compound demonstrates notable potential in reducing neuroinflammation associated with Alzheimer´s disease research [1].

    价 格：￥电议型 号：T61620产 地：中国大陆

  • T61537ASIC-IN-1；化合物 ASIC-IN-1ASIC-IN-1

    ASIC-IN-1 is a potent inhibitor of acid-sensing ion channels, demonstrating an IC 50 value of less than 10 μM. It effectively reduces pain intensity in a dose-dependent manner [1].

    价 格：￥电议型 号：T61537产 地：中国大陆

  • T61536A1AR antagonist 4；化合物 A1AR antagonist 4A1AR antagonist 4

    A1AR antagonist 4 (compound 22) is a highly developed chemical compound that acts as a potent and selective antagonist of the A1 adenosine receptor (A1AR). It possesses a pIC50 value of 5.51 and a pKi value of 6.29 [1].

    价 格：￥电议型 号：T61536产 地：中国大陆

  • T61487APE1-IN-1；APE1抑制剂1APE1-IN-1

    APE1-IN-1 is a potent purine/pyrimidine endonuclease 1 (APE1)-free inhibitor that crosses the blood-brain barrier with potential antitumor activity and potentiates the cytotoxicity of the alkylating agent, methyl methanesulfonate, on cancer cells.

    价 格：￥电议型 号：T61487产 地：中国大陆

  • T61326AIMP2-DX2-IN-1；AIMP2-DX2抑制剂1AIMP2-DX2-IN-1

    AIMP2-DX2-IN-1 is a potent AIMP2-DX2 inhibitor with potential antitumor activity for the study of lymphoma.

    价 格：￥电议型 号：T61326产 地：中国大陆

  • T61317Anabolic agent-1；化合物 Anabolic agent-1Anabolic agent-1

    Anabolic agent-1 is a novel bone morphogenetic protein-2 up regulator, with the capability of rectifying bone loss in patients and exhibiting versatile clinical applicability.

    价 格：￥电议型 号：T61317产 地：中国大陆

  • T61287CYP121A1-IN-1；化合物 CYP121A1-IN-1CYP121A1-IN-1

    CYP121A1-IN-1 is a potent inhibitor of CYP121A1, demonstrating favorable activity against Mycobacterium tuberculosis (H37Rv MIC 90 ~6.25 μM, ~2.2 μg/mL). It significantly reduces mycocyclosin production by blocking the CYP121A1-mediated conversion of cyclo(l-tyrosyl-l-tyrosyl) to mycocyclosin [1].

    价 格：￥电议型 号：T61287产 地：中国大陆

  • T61278Aminopeptidase-IN-1；氨基肽酶-IN1Aminopeptidase-IN-1

    Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and memory disorders.

    价 格：￥电议型 号：T61278产 地：中国大陆

  • T61269Anti-osteoporosis agent-1；化合物 Anti-osteoporosis agent-1Anti-osteoporosis agent-1

    Anti-osteoporosis agent-1 (comp 4aa) is an effective RPA (replication protein A) inhibitor, demonstrating potency with an IC50 value of 18 μM [1].

    价 格：￥电议型 号：T61269产 地：中国大陆

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