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  • T74978DPP IV/hCA II-IN-1；化合物 DPP IV/hCA II-IN-1DPP IV/hCA II-IN-1

    DPP IV/hCA II-IN-1 is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA), exhibiting an IC50 of 0.049 μM for DPP IV and K_i values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and 3.034 μM for CA II, CA VB, CA VA, CA IX, CA I, and CA IV, respectively [1].

    价 格：￥电议型 号：T74978产 地：中国大陆

  • T74965CypE-IN-1；化合物 CypE-IN-1CypE-IN-1

    CypD-IN-1, a potent and subtype-selective inhibitor targeting cyclophilin E (CypE), demonstrates high affinity with IC50 and Ki values of 0.013 μM and 0.072 μM, respectively. This compound is valuable for research into various conditions, including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy, and diabetes [1].

    价 格：￥电议型 号：T74965产 地：中国大陆

  • T74962GLUT1-IN-1；化合物 GLUT1-IN-1GLUT1-IN-1

    GLUT1-IN-1, a glucose transporter 1 (GLUT1) inhibitor, possesses specific inactivation capability for GLUT1. This compound demonstrates concentration-dependent cytotoxicity towards HeLa, A549, and HepG2 cells, with IC50 values of 5.49 μM, 11.14 μM, and 8.73 μM, respectively. It is utilized in the research of photodynamic therapy (PDT) and several cancers [1].

    价 格：￥电议型 号：T74962产 地：中国大陆

  • T74955hCAIX-IN-13；化合物 hCAIX-IN-13hCAIX-IN-13

    hCAIX-IN-13 (Pt2), a Carbonic Anhydrase IX (CAIX) inhibitor, demonstrates a notable IC50 value of 6.57 μM, efficiently impeding cancer cell growth and promoting apoptosis. It is valuable for cancer research [1].

    价 格：￥电议型 号：T74955产 地：中国大陆

  • T74939HIV protease-IN-1；化合物 HIV protease-IN-1HIV protease-IN-1

    HIV protease-IN-1 (compound 1·succinate), a potent non-peptidic inhibitor of HIV protease, is utilized for AIDS research [1].

    价 格：￥电议型 号：T74939产 地：中国大陆

  • T74932Trypanothione synthetase-IN-1；化合物 Trypanothione synthetase-IN-1Trypanothione synthetase-IN-1

    Trypanothione Synthetase-IN-1 (Compound 1) serves as a competitive inhibitor of Leishmania infantum trypanothione synthetase (TryS), demonstrating an IC50 value of 14.8 μM in the presence of the polyamine S, triamine spermidine [1].

    价 格：￥电议型 号：T74932产 地：中国大陆

  • T74929Phytoene desaturase-IN-1；化合物 Phytoene desaturase-IN-1Phytoene desaturase-IN-1

    Phytoene desaturase-IN-1, a potent inhibitor of phytoene desaturase (PDS) with a dissociation constant (Kd) of 65.9 μM, acts through π?π stacking interaction with the Phe301 residue. This compound exhibits a broad spectrum of post-emergence herbicidal effects by inducing a reduction in PDS mRNA, and accumulation of phytoene and reactive oxygen species (ROS) in albino leaves, suggesting its utility in agricultural production [1].

    价 格：￥电议型 号：T74929产 地：中国大陆

  • T74917KPC-2-IN-1；化合物 KPC-2-IN-1KPC-2-IN-1

    KPC-2-IN-1, a boronic acid derivative, serves as an effective KPC-2 inhibitor with a K i of 0.032 μM, augmenting cefotaxime´s efficacy against KPC-2 expressing E. coli. It demonstrates good tolerance in human HEK-293 cells, rendering it valuable for researching E. coli´s resistance to β-lactam antibiotics [1] [2].

    价 格：￥电议型 号：T74917产 地：中国大陆

  • T74894SIRT1/2/3-IN-1；化合物 SIRT1/2/3-IN-1SIRT1/2/3-IN-1

    SIRT1/2/3-IN-1 (compound 10) is a potent, selective, and cell-permeable inhibitor targeting SIRT1, SIRT2, and SIRT3, demonstrating inhibitory concentrations (IC50s) of 0.54 μM, 0.253 μM, and 0.72 μM, respectively. It is utilized in cancer research [1].

    价 格：￥电议型 号：T74894产 地：中国大陆

  • T74859SLC7A11-IN-1；化合物 SLC7A11-IN-1SLC7A11-IN-1

    SLC7A11-IN-1 is a potent inhibitor of the solute carrier family 7 member 11 (SLC7A11, xCT), exhibiting antiproliferative, anti-tumor activities, and the ability to inhibit cell invasion and metastasis. It induces apoptosis and arrests cell cycle progression in the S-phase [1].

    价 格：￥电议型 号：T74859产 地：中国大陆

  • T74834MTHFD2-IN-1；化合物 MTHFD2-IN-1MTHFD2-IN-1

    MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].

    价 格：￥电议型 号：T74834产 地：中国大陆

  • T74830PDK-IN-1；化合物 PDK-IN-1PDK-IN-1

    PDK-IN-1 (compound 7o), a pyruvate dehydrogenase kinase (PDK) inhibitor, exhibits IC50 values of 0.03 and 0.1 μM against PDK1 and HSP90, respectively. This compound effectively targets the PDH/PDK axis, significantly reducing tumor mass [1].

    价 格：￥电议型 号：T74830产 地：中国大陆

  • T74826AcrB-IN-1；化合物 AcrB-IN-1AcrB-IN-1

    AcrB-IN-1 (Compound H6) is a highly effective inhibitor of AcrB, utilized for the reversal of bacterial multidrug resistance [1].

    价 格：￥电议型 号：T74826产 地：中国大陆

  • T74819IL-1β-IN-1；化合物 IL-1β-IN-1IL-1β-IN-1

    IL-1β-IN-1, a cannabidiol derivative, acts as a potent inhibitor of IL-1β, exhibiting significant anti-inflammatory and pain relief properties [1].

    价 格：￥电议型 号：T74819产 地：中国大陆

  • T74816Complement C1s-IN-1；化合物 Complement C1s-IN-1Complement C1s-IN-1

    Complement C1s-IN-1 is a potent and selective C1s inhibitor that is orally active and capable of crossing the blood-brain barrier, demonstrating an IC50 value of 36 nM [1].

    价 格：￥电议型 号：T74816产 地：中国大陆

  • T74814PKM2/PDK1-IN-1；化合物 PKM2/PDK1-IN-1PKM2/PDK1-IN-1

    PKM2/PDK1-IN-1, a shikonin thioether derivative, serves as a dual inhibitor for PKM2/PDK1. This compound effectively inhibits the proliferation and induces apoptosis in NSCLC cells. It promotes intercellular ROS production and modulates apoptotic proteins, engaging in both mitochondrial and death receptor pathways [1].

    价 格：￥电议型 号：T74814产 地：中国大陆

  • T74812hBChE-IN-1；化合物 hBChE-IN-1hBChE-IN-1

    hBChE-IN-1 (compound 4), a quinolizidinyl derivative, effectively inhibits human Butyrylcholinesterase (hBChE) with an IC50 value of 7 nM, demonstrating high selectivity against human Acetylcholinesterase (hAChE). It also possesses inhibitory properties against tau and Aβ 40 protein aggregation, exhibiting IC50 values of 20 and 4.3 μM, respectively, making it a valuable asset for Alzheimer´s disease research [1].

    价 格：￥电议型 号：T74812产 地：中国大陆

  • T74811tau/Aβ40 aggregation-IN-1；化合物 tau/Aβ40 aggregation-IN-1tau/Aβ40 aggregation-IN-1

    Tau/Aβ40 aggregation-IN-1 (Compound 20) functions as an inhibitor for tau and Aβ 40 aggregation, exhibiting IC50 values of 1.8 μM and 1.3 μM, respectively [1].

    价 格：￥电议型 号：T74811产 地：中国大陆

  • T74807SARS-CoV-2 3CLpro-IN-13；化合物 SARS-CoV-2 3CLpro-IN-13SARS-CoV-2 3CLpro-IN-13

    SARS-CoV-2 3CLpro-IN-13 is a potent inhibitor of the SARS-CoV-2 3CL protease, demonstrating significant anti-coronavirus activity with an IC50 value of 21 nM [1].

    价 格：￥电议型 号：T74807产 地：中国大陆

  • T74778ASM-IN-1；化合物 ASM-IN-1ASM-IN-1

    ASM-IN-1 is a potent, orally active inhibitor of acid sphingomyelinase (ASM) with an IC50 of 1.5 ?M, demonstrating antiatherosclerotic and anti-inflammatory activity. It effectively reduces lipid plaques in the aortic arch and aorta, along with decreasing plasma ceramide concentrations and oxidized LDL (Ox-LDL) levels [1].

    价 格：￥电议型 号：T74778产 地：中国大陆

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