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  • T79499KSK68；化合物KSK68KSK68

    KSK68 is a potent dual sigma-1 and histamine H3 receptor antagonist with potential analgesic activity and high affinity for H3 receptors, sigma-1, sigma-2 receptors.KSK68 can be used in the study of pain related diseases.

    价 格：￥电议型 号：T79499产 地：中国大陆

  • T79498M867；化合物 M867M867

    M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].

    价 格：￥电议型 号：T79498产 地：中国大陆

  • T79497M826；化合物 M826M826

    M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in vitro and in vivo animal models. It is useful for research into nervous system diseases [1].

    价 格：￥电议型 号：T79497产 地：中国大陆

  • T79496Cathepsin C-IN-6；化合物 Cathepsin C-IN-6Cathepsin C-IN-6

    Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastase activation. This compound demonstrates potential efficacy in treating inflammatory diseases characterized by elevated neutrophil counts, such as chronic obstructive pulmonary disease (COPD) [1].

    价 格：￥电议型 号：T79496产 地：中国大陆

  • T79495VEGFR-2-IN-32；化合物 VEGFR-2-IN-32VEGFR-2-IN-32

    VEGFR-2-IN-32 (Comp 3a) is an inhibitor of VEGFR-2, exhibiting an inhibitory concentration (IC 50) of 8.93 nM, and demonstrates cytotoxic activity towards PC-3 cells with an IC 50 of 1.22 μM, indicating its potential utility in anti-prostate cancer research [1].

    价 格：￥电议型 号：T79495产 地：中国大陆

  • T79494VEGFR-2-IN-31；化合物 VEGFR-2-IN-31VEGFR-2-IN-31

    VEGFR-2-IN-31 (compound 3i), a robust VEGFR-2 inhibitor (IC50=8.93 nM), serves as an anti-prostate cancer agent by arresting the cell cycle at the S-phase and inducing apoptosis.

    价 格：￥电议型 号：T79494产 地：中国大陆

  • T79493HIV-1 protease-IN-10；化合物 HIV-1 protease-IN-10HIV-1 protease-IN-10

    HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) and demonstrates stability against esterase-mediated hydrolysis [1].

    价 格：￥电议型 号：T79493产 地：中国大陆

  • T79492h-NTPDase8-IN-1；h-NTPDase8 抑制剂 1h-NTPDase8-IN-1

    h-NTPDase8-IN-1 is a specific aminosulfonylbenzamide inhibitor of h-NTPDases8 (IC 50 = 0.28 ± 0.07 μM). h-NTPDase8-IN-1 can be used to study diseases brought about by aberrant h -NTPDase expression.

    价 格：￥电议型 号：T79492产 地：中国大陆

  • T79491h-NTPDase-IN-1；化合物 h-NTPDase-IN-1h-NTPDase-IN-1

    h-NTPDase-IN-1 (Compound 3i) is an inhibitor of human NTPDase (h-NTPDase) with IC50 values of 2.88 μM for h-NTPDase1 and 0.72 μM for h-NTPDase3, indicating its potential utility for thrombosis, inflammation, diabetes, and cancer research [1].

    价 格：￥电议型 号：T79491产 地：中国大陆

  • T79490LT-540-717；化合物 LT-540-717LT-540-717

    LT-540-717 (compound 32), a potent FLT3 inhibitor (IC50=0.62 nM), exhibits antiproliferative activity and effectively inhibits various acquired FLT3 mutations, including FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y), and FLT3 (D835V), indicating its potential as an anti-AML agent [1].

    价 格：￥电议型 号：T79490产 地：中国大陆

  • T7949NCC007；化合物NCC007NCC007

    NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.

    价 格：￥电议型 号：T7949产 地：中国大陆

  • T79489JNK-1-IN-2；化合物 JNK-1-IN-2JNK-1-IN-2

    "JNK-1-IN-2 (Compound c6) is a potent inhibitor of JNK-1 with an IC50 of 33.5 nM, and also exhibits inhibitory effects on JNK-2 and JNK-3 with IC50 values of 112.9 nM and 33.2 nM, respectively. This compound effectively inhibits the phosphorylation of c-Jun and has shown potential in reversing lung impairment, making it relevant for research into pulmonary fibrosis [1]."

    价 格：￥电议型 号：T79489产 地：中国大陆

  • T79488RNase L-IN-1；化合物 RNase L-IN-1RNase L-IN-1

    RNase L-IN-1 (compound 17a) functions as an inhibitor of RNase L (Ribonuclease L), an enzyme responsible for RNA degradation to inhibit viral replication, and plays a crucial role in mediating innate immune responses and inflammation [1].

    价 格：￥电议型 号：T79488产 地：中国大陆

  • T79487MAO A/HSP90-IN-2；化合物 MAO A/HSP90-IN-2MAO A/HSP90-IN-2

    MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90. This compound not only enhances HSP70 expression but also diminishes HER2 and phospho-Akt levels, and downregulates IFN-γ-induced PD-L1 expression in GL26 cells. Demonstrating efficacy against Temozolomide-sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung cancer, and other malignancies, MAO A/HSP90-IN-2 may also impede tumor immune

    价 格：￥电议型 号：T79487产 地：中国大陆

  • T79486MAO A/HSP90-IN-1；化合物 MAO A/HSP90-IN-1MAO A/HSP90-IN-1

    MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α. This compound impairs the activities of MAO A, disrupts HSP90 binding, and downregulates both HER2 and phospho-Akt expressions, thereby inhibiting GBM growth. Additionally, it diminishes PD-L1 expression, thereby thwarting T cell activation and potential tumor immune evasion. MAO A/HSP90-IN-1 (4-b) is valuable for research into brain tumor

    价 格：￥电议型 号：T79486产 地：中国大陆

  • T79485IRAK4-IN-27；化合物 IRAK4-IN-27IRAK4-IN-27

    IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line, positioning it as a valuable agent for DLBCL research [1].

    价 格：￥电议型 号：T79485产 地：中国大陆

  • T79484Nrf2 activator-8；化合物 Nrf2 activator-8Nrf2 activator-8

    Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties in BV-2 microglial cells. Furthermore, this compound notably ameliorates spatial memory deficits in a mouse model of lipopolysaccharide (LPS)-induced neuroinflammation [1].

    价 格：￥电议型 号：T79484产 地：中国大陆

  • T79483MDM2/XIAP-IN-3；化合物 MDM2/XIAP-IN-3MDM2/XIAP-IN-3

    MDM2/XIAP-IN-3 (compound 3e), a dual inhibitor of MDM2/XIAP, diminishes MDM2 and XIAP protein levels while augmenting p53 expression, consequently suppressing cancer cell proliferation and inducing apoptosis [1].

    价 格：￥电议型 号：T79483产 地：中国大陆

  • T79482Anticancer agent 137；化合物 Anticancer agent 137Anticancer agent 137

    Anticancer agent 137 (8q), a potent PI3k inhibitor, exhibits broad-spectrum anticancer activity by inducing G2/M cell cycle arrest and apoptosis. It increases levels of cleaved PARP, and caspases 3 and 7, making it useful in cancer research [1].

    价 格：￥电议型 号：T79482产 地：中国大陆

  • T79481Chitin synthase inhibitor 13；化合物 Chitin synthase inhibitor 13Chitin synthase inhibitor 13

    Chitin Synthase Inhibitor 13 (compound 12g), a non-competitive antagonist of chitin synthase, demonstrates broad-spectrum antifungal activity and has an inhibition concentration (IC50) of 106.7 μM [1].

    价 格：￥电议型 号：T79481产 地：中国大陆

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