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  • T79426SARS-CoV-2-IN-61；化合物 SARS-CoV-2-IN-61SARS-CoV-2-IN-61

    SARS-CoV-2-IN-61 (compound 8i) is a potent inhibitor of the SARS-CoV-2 PLpro, exhibiting an IC50 of 16 ?M and demonstrating antiviral activities [1].

    价 格：￥电议型 号：T79426产 地：中国大陆

  • T79425TGR5 agonist 4；化合物 TGR5 agonist 4TGR5 agonist 4

    TGR5 agonist 4 (compound 19), a derivative of cholic acid, selectively activates the TGR5 receptor with an effective concentration (EC50) of 4 μM [1].

    价 格：￥电议型 号：T79425产 地：中国大陆

  • T79424TGR5 agonist 3；化合物 TGR5 agonist 3TGR5 agonist 3

    Compound 8, a cholic acid derivative, functions as a selective TGR5 agonist and exhibits an EC50 value of 5 μM [1].

    价 格：￥电议型 号：T79424产 地：中国大陆

  • T79423BuChE-IN-9；化合物 BuChE-IN-9BuChE-IN-9

    BuChE-IN-9 (compound 22a), an eqBuChE (equine serum-derived butyrylcholinesterase) inhibitor, exhibits potent activity with an IC50 of 173 nM. In addition to eqBuChE, it also inhibits human BACE1, Aβ aggregation, and mouse GABA transporters 1 and 4 (mGAT1 and mGAT4). Notably, BuChE-IN-9 demonstrates significant antiamnesic properties [1].

    价 格：￥电议型 号：T79423产 地：中国大陆

  • T79422BuChE-IN-8；化合物 BuChE-IN-8BuChE-IN-8

    BuChE-IN-8 (compound 19c), a butyrylcholinesterase (BuChE) inhibitor, exhibits an IC50 value of 559 nM and concurrently inhibits human β-secretase (BACE1) and Aβ40 aggregation. It also demonstrates notable antiamnesic properties [1].

    价 格：￥电议型 号：T79422产 地：中国大陆

  • T79421DCLK1-IN-2；化合物 DCLK1-IN-2DCLK1-IN-2

    DCLK1-IN-2 (Compound I-5) is a potent inhibitor of DCLK1, exhibiting an IC50 of 171.3 nM, and demonstrates significant antiproliferative effects on SW1990 cell lines with an IC50 of 0.6 μM, as well as in vivo antitumor potency [1].

    价 格：￥电议型 号：T79421产 地：中国大陆

  • T79420FLT3-IN-22；化合物 FLT3-IN-22FLT3-IN-22

    FLT3-IN-22 (compound 22f) is a potent inhibitor of FLT3, demonstrating IC50 values of 0.941 nM for FLT3 and 0.199 nM for the FLT3/D835Y mutant. This compound displays significant antiproliferative effects against MV4-11 cells and Ba/F3 cell lines expressing mutant FLT kinase variants, such as FLT-D835Y and FLT3-F691L [1].

    价 格：￥电议型 号：T79420产 地：中国大陆

  • T7942Tranylcypromine hemisulfate；反苯环丙胺半硫酸盐Tranylcypromine Sulfate|||Tranylcypromine (hemisulfate)；Tranylc

    Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.

    价 格：￥电议型 号：T7942产 地：中国大陆

  • T79419Antileishmanial agent-24；化合物 Antileishmanial agent-24Antileishmanial agent-24

    Antileishmanial agent-24 (compound 33) exhibits antileishmanial activity, demonstrating an inhibitory concentration 50 (IC50) value of 5.39 μM against amastigotes [1].

    价 格：￥电议型 号：T79419产 地：中国大陆

  • T79418BLT2 antagonist-1；化合物 BLT2 antagonist-1BLT2 antagonist-1

    BLT2 antagonist-1 (compound 15b) is a selective inhibitor of the BLT2 receptor, impeding the chemotaxis of CHO-BLT2 cells at an IC50 of 224 nM, while not affecting CHO-BLT1 cell chemotaxis. It blocks the interaction between LTB4 and the BLT2 receptor with a K_i of 132 nM and may serve as a research tool for inflammatory airway diseases, including asthma and chronic obstructive pulmonary disease [1].

    价 格：￥电议型 号：T79418产 地：中国大陆

  • T79417PITB；化合物 PITBPITB

    PITB, a selective and orally active transthyretin (TTR) aggregation inhibitor, is utilized in transthyretin amyloidosis (ATTR) disease research [1].

    价 格：￥电议型 号：T79417产 地：中国大陆

  • T79416FASN-IN-6；化合物 FASN-IN-6FASN-IN-6

    FASN-IN-6 (compound 44), a potent fatty acid biosynthesis (FAB) inhibitor, serves as an antibacterial agent, exhibiting minimum inhibitory concentrations (MICs) of 1 μg/mL for S. aureus ATCC 25923 and 4 μg/mL for E. faecalis ATCC 29212 [1].

    价 格：￥电议型 号：T79416产 地：中国大陆

  • T79415Antiparasitic agent-18；化合物 Antiparasitic agent-18Antiparasitic agent-18

    Antiparasitic agent-18 (compound 3a) exhibits potent and selective antiprotozoal activity, demonstrating effective inhibition of T. brucei (EC 50 =0.4 ?M), T. cruzi (EC 50 =0.21 ?M), and L. donovani (EC 50 =0.26 ?M) [1].

    价 格：￥电议型 号：T79415产 地：中国大陆

  • T79414SARS-CoV-2-IN-60；化合物 SARS-CoV-2-IN-60SARS-CoV-2-IN-60

    SARS-CoV-2-IN-60 (compound 5a) is a specific, irreversible inhibitor of SARS-CoV-2 nsp16-nsp10 methyltransferase, competing with S-adenosylmethionine (SAM) and exhibiting an IC50 of 9 ?M and a Ki of 26 ?M. It binds to a novel pocket near the SAM-binding site on nsp16, suggesting potential as a pan-coronavirus therapeutic [1].

    价 格：￥电议型 号：T79414产 地：中国大陆

  • T79413Antifungal agent 73；化合物 Antifungal agent 73Antifungal agent 73

    Antifungal agent 73 (compound A32) effectively combats azole-resistant candidiasis by disrupting the fungal cell wall and membrane. It demonstrates potent in vivo activity against pathogenic fungi, including fluconazole-resistant strains [1].

    价 格：￥电议型 号：T79413产 地：中国大陆

  • T79412SHP2-IN-16；化合物 SHP2-IN-16SHP2-IN-16

    SHP2-IN-16 (compound 222) is a potent SHP2 inhibitor exhibiting an IC50 of 1 nM, and is applicable in glioblastoma research [1].

    价 格：￥电议型 号：T79412产 地：中国大陆

  • T79411hCAXII-IN-7；化合物 hCAXII-IN-7hCAXII-IN-7

    hCAXII-IN-7 (compound 6e) functions as an inhibitor of human carbonic anhydrase XII (hCA XII) and possesses blood-brain barrier (BBB) permeability. Moreover, it promotes apoptosis in 786-0, SF-539, and HS 578 T cell lines [1].

    价 格：￥电议型 号：T79411产 地：中国大陆

  • T79410anti-TNBC agent-3；化合物 anti-TNBC agent-3anti-TNBC agent-3

    Anti-TNBC agent-3 (compound 3g) is a compound that induces apoptosis and possesses anti-cancer cell proliferation properties. It effectively inhibits tumor growth and metastasis in xenograft models of triple-negative breast cancer (TNBC) [1].

    价 格：￥电议型 号：T79410产 地：中国大陆

  • T7941Imipramine hydrochloride；盐酸丙咪嗪Imipramine (hydrochloride)|||Tofranil|||G 22355|||Imipramine HCl|||Mel

    Imipramine hydrochloride (Imipramine HCl) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively).Imipramine hydrochloride is reported to prevent the translocation of aSMase, inhibiting MV and exosomes secretion

    价 格：￥电议型 号：T7941产 地：中国大陆

  • T79409Antibacterial agent 154；化合物 Antibacterial agent 154Antibacterial agent 154

    Antibacterial Agent 154 (Compound 7), a Fluoroquinolone derivative, exhibits broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria when administered orally. It has been shown to be effective in vivo using a mouse model of staphylococcal sepsis [1].

    价 格：￥电议型 号：T79409产 地：中国大陆

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