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  • T79480Anti-inflammatory agent 47;化合物 Anti-inflammatory agent 47Anti-inflammatory agent 47

    Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neuronal apoptosis by modulating inflammatory and apoptotic signaling pathways, showcasing potential utility in Parkinson´s Disease (PD) research [1].

    价 格:¥电议型 号:T79480产 地:中国大陆

  • T7948HPGDS inhibitor 2化合物GSK-2894631AGSK-2894631A

    HPGDS inhibitor 2 (GSK-2894631A) is a potent, selective hematopoietic prostaglandin D synthase (h-pgds) inhibitor, IC50 = 9.9 nm.

    价 格:¥电议型 号:T7948产 地:中国大陆

  • T79479MptpB-IN-2;化合物 MptpB-IN-2MptpB-IN-2

    MptpB-IN-2 (compound 20), a selective inhibitor for mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), exhibits half maximal inhibitory concentrations (IC50) of 0.64 μM for MptpB, 4.06 μM for MptpA, and 4.14 μM for PTP1B. Despite its inhibition potency, MptpB-IN-2 demonstrates limited antituberculosis efficacy, with a minimum inhibitory concentration (MIC) of 64.9 μM against Mtb H37Rv [1].

    价 格:¥电议型 号:T79479产 地:中国大陆

  • T79478Anti-inflammatory agent 45;化合物 Anti-inflammatory agent 45Anti-inflammatory agent 45

    Compound 2v (Anti-inflammatory agent 45) demonstrates anticancer properties with direct inhibitory impacts on the proliferation of various blood malignancies, such as leukemia, lymphoma, and myeloma cell lines. It induces apoptosis and suppresses nitric oxide production in HL60 leukemia cells (IC50 = 14.7 μM) [1].

    价 格:¥电议型 号:T79478产 地:中国大陆

  • T79477SCAL-266;化合物 SCAL-266SCAL-266

    SCAL-266, a potent inhibitor of mitochondrial complex I (CI), exhibits an IC50 of 0.83 μM. This compound impairs mitochondrial function by blocking oxidative phosphorylation (OXPHOS), inhibiting oxygen consumption rate (OCR), increasing reactive oxygen species (ROS) production, and diminishing mitochondrial membrane potential (MMP). Furthermore, SCAL-266 demonstrates significant antiproliferative activity against OXPHOS-dependent cancer cells [1].

    价 格:¥电议型 号:T79477产 地:中国大陆

  • T79476SCAL-255;化合物 SCAL-255SCAL-255

    SCAL-255 is a mitochondrial complex I (CI) inhibitor, exhibiting potent inhibition with an IC50 of 1.14 μM. It impedes mitochondrial function by blocking oxygen consumption rate (OCR), inducing reactive oxygen species (ROS) production, and diminishing mitochondrial membrane potential (MMP). Furthermore, SCAL-255 significantly hampers the proliferation of cancer cells reliant on oxidative phosphorylation (OXPHOS) [1].

    价 格:¥电议型 号:T79476产 地:中国大陆

  • T79475GPR119 agonist 2;化合物 GPR119 agonist 2GPR119 agonist 2

    GPR119 agonist 2 (compound 43), an orally active agonist of GPR119, exhibits favorable pharmacokinetic properties in rodents and has demonstrated efficacy in enhancing glucose tolerance in both mice and rats, indicating its potential in type 2 diabetes research [1].

    价 格:¥电议型 号:T79475产 地:中国大陆

  • T79474GSPT1 degrader-1;化合物 GSPT1 degrader-1GSPT1 degrader-1

    GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces G0/G1 phase arrest and apoptosis in cells [1].

    价 格:¥电议型 号:T79474产 地:中国大陆

  • T79473Anti-inflammatory agent 46;化合物 Anti-inflammatory agent 46Anti-inflammatory agent 46

    Anti-inflammatory agent 46 (compound 7h), exhibiting nitric oxide (NO) inhibitory properties, demonstrates a high affinity for iNOS through low binding energies and effectively reduces swelling in mouse models at a dose of 10 mg/kg [1].

    价 格:¥电议型 号:T79473产 地:中国大陆

  • T79472CSF1R-IN-17;化合物 CSF1R-IN-17CSF1R-IN-17

    CSF1R-IN-17 (compound 9) is a potent, selective antagonist of CSF1R, exhibiting an inhibition concentration half-maximum (IC50) of 0.2 nM. It is capable of inhibiting osteoclast differentiation [1].

    价 格:¥电议型 号:T79472产 地:中国大陆

  • T79471Antileishmanial agent-20;化合物 Antileishmanial agent-20Antileishmanial agent-20

    Antileishmanial agent-20 exhibits selectivity against the Leishmania parasite, with IC50 values of 2.8 μM for L. infantum and 0.2 μM for L. braziliensis. It is a potential research tool for studying these parasites [1].

    价 格:¥电议型 号:T79471产 地:中国大陆

  • T79470RORγt inverse agonist 31;化合物 RORγt inverse agonist 31RORγt inverse agonist 31

    RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (IC50) of 0.428 μM. It has demonstrated efficacy in mitigating Imiquimod-induced psoriasis severity in murine models [1].

    价 格:¥电议型 号:T79470产 地:中国大陆

  • T7947FT113;化合物FT113FT113

    FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity

    价 格:¥电议型 号:T7947产 地:中国大陆

  • T79469HBV-IN-34;化合物 HBV-IN-34HBV-IN-34

    HBV-IN-34 (compound 17i) is a potent inhibitor of HBsAg production, demonstrating remarkable in vitro anti-HBV efficacy with EC50 values of 0.018 μM for HBV DNA and 0.044 μM for HBsAg [1].

    价 格:¥电议型 号:T79469产 地:中国大陆

  • T79468Antimicrobial agent-22;化合物 Antimicrobial agent-22Antimicrobial agent-22

    Antimicrobial agent-22 (THI 6c) constitutes a broad-spectrum, multi-target antibacterial with notable rapid bactericidal efficacy and effective anti-biofilm activity, paired with low cytotoxicity and hemolytic properties [1].

    价 格:¥电议型 号:T79468产 地:中国大陆

  • T79467Antifungal agent 60;化合物 Antifungal agent 60Antifungal agent 60

    Antifungal agent 60 (compound 16), a broad-spectrum ergosterol biosynthesis inhibitor, demonstrates potent activity against seven human pathogenic fungal species, including two fluconazole-resistant C. albicans isolates and two multi-drug resistant Candida auris isolates.

    价 格:¥电议型 号:T79467产 地:中国大陆

  • T79466Antitumor agent-111;化合物 Antitumor agent-111Antitumor agent-111

    Antitumor Agent-111 (Compound 46), a c-Met kinase inhibitor (IC50 = 46 nM), exhibits both antitumor and antiproliferative effects. It impedes the cell cycle at the G0/G1 phase and induces apoptosis [1].

    价 格:¥电议型 号:T79466产 地:中国大陆

  • T79465Anticancer agent 135;化合物 Anticancer agent 135Anticancer agent 135

    Anticancer agent 135 (compound 26h) acts as a potent androgen receptor (AR) antagonist, effectively blocking AR nuclear translocation and inhibiting AR/AR-V7 heterodimerization to suppress downstream gene transcription. This compound demonstrates strong efficacy in prostate cancer xenograft models [1].

    价 格:¥电议型 号:T79465产 地:中国大陆

  • T79464RORγ antagonist 1;化合物 RORγ antagonist 1RORγ antagonist 1

    RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM. It demonstrates anti-proliferative effects in the HPAF-II pancreatic cancer xenograft model, inhibits the RAS/MAPK and AKT/mTORC1 signaling pathways, and triggers caspase-dependent apoptosis in pancreatic cancer cells [1].

    价 格:¥电议型 号:T79464产 地:中国大陆

  • T79463Antitumor agent-110;化合物 Antitumor agent-110Antitumor agent-110

    Antitumor Agent-110 (Compound 13), an imidazotetrazine anticancer agent, exhibits excellent permeability. It halts the cell cycle at the G2/M phase and induces apoptosis [1].

    价 格:¥电议型 号:T79463产 地:中国大陆

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