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T79462SARS-CoV-2 3CLpro-IN-14；化合物 SARS-CoV-2 3CLpro-IN-14SARS-CoV-2 3CLpro-IN-14
SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active inhibitor of SARS-CoV-2 3CLpro, demonstrating potent anti-SARS-CoV-2 properties with an EC50 of 0.18 μM and exhibits minimal cytotoxicity, having a CC50 greater than 50 μM, in Vero E6 cells [1].
价 格：￥电议型 号：T79462产 地：中国大陆
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T79461YK-029A；化合物 YK-029AYK-029A
YK-029A, an orally active EGFR mutant inhibitor, targets both EGFR T790M and EGFRex20ins mutations. It demonstrates notable antitumor efficacy, inducing tumor regression in EGFRex20ins-driven patient-derived xenograft (PDX) models [1].
价 格：￥电议型 号：T79461产 地：中国大陆
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T79460Antimalarial agent 28；化合物 Antimalarial agent 28Antimalarial agent 28
Antimalarial agent 28 (Compound 2i) acts as an antiplasmodial agent, exhibiting inhibition of P. berghei with IC50 values of 0.561 μM for the liver stage, 0.14 μM for early gametocytes, and 4.34 μM for the ring stages of P. falciparum [1].
价 格：￥电议型 号：T79460产 地：中国大陆
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T7945917β-HSD10-IN-2；化合物 17β-HSD10-IN-217β-HSD10-IN-2
17β-HSD10-IN-2 (compound 11), a benzothiazolylurea-based inhibitor, specifically targets 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10), avoiding mitochondrial off-targets as well as cytotoxic or neurotoxic effects. This multifunctional mitochondrial enzyme inhibitor has potential applications in Alzheimer´s disease (AD) and hormone-dependent cancer research [1].
价 格：￥电议型 号：T79459产 地：中国大陆
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T79458YF704；化合物 YF704YF704
YF704 (compound 4w), a selective allosteric inhibitor of SHP2, exhibits antiproliferative effects and induces apoptosis in cancer cells with an IC50 of 0.25 μM. Furthermore, it downregulates Erk1/2 and Akt phosphorylation levels in cancer cells [1].
价 格：￥电议型 号：T79458产 地：中国大陆
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T79457PEX5-PEX14 PPI-IN-1；化合物 PEX5-PEX14 PPI-IN-1PEX5-PEX14 PPI-IN-1
PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor that disrupts the interaction between PEX5 and TbPEX14 with an inhibitory constant (Ki) of 53 μM. It effectively inhibits the bloodstream form of Trypanosoma brucei brucei, with a half-maximal effective concentration (EC50) of 5 μM [1].
价 格：￥电议型 号：T79457产 地：中国大陆
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T79456FD1024；化合物 FD1024FD1024
FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively. It demonstrates significant antiproliferative effects on several AML cell lines, with IC50 values of 0.16 μM for EOL-1, 0.12 μM for MV-4-11, 1.05 μM for KG-1, and 1.39 μM for MOLM-16. Additionally, FD1024 has shown antitumor efficacy in murine models [1].
价 格：￥电议型 号：T79456产 地：中国大陆
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T79455SARS-CoV-2 Mpro-IN-9；化合物 SARS-CoV-2 Mpro-IN-9SARS-CoV-2 Mpro-IN-9
SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) and improved physicochemical and drug metabolism and pharmacokinetics (DMPK) properties. It effectively suppresses viral replication in SARS-CoV-2-infected Vero E6 cells (EC50 = 1.10 μM) and demonstrates low cytotoxicity (CC50 > 50 μM) [1].
价 格：￥电议型 号：T79455产 地：中国大陆
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T79454Anti-NASH agent 1；化合物 Anti-NASH agent 1Anti-NASH agent 1
Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH). At dosages of 3-10 mg/kg over four weeks, this compound ameliorates hyperlipidemia, liver fat degeneration, and inflammation in a methionine-choline deficiency (MCD)-induced NASH mouse model, exhibiting minimal hepatotoxicity while providing substantial hepatic protection [1].
价 格：￥电议型 号：T79454产 地：中国大陆
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T79453Anticancer agent 134；化合物 Anticancer agent 134Anticancer agent 134
Anticancer Agent 134 (Compound 6a), an environment-sensitive fluorescent probe, induces apoptosis and selectively differentiates between tumor and normal tissues. This agent specifically targets nuclear bodies within tumor sections [1].
价 格：￥电议型 号：T79453产 地：中国大陆
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T79452Tubulin/HDAC-IN-2；化合物 Tubulin/HDAC-IN-2Tubulin/HDAC-IN-2
Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor targeting Tubulin and HDAC, exhibiting IC50 values of 0.403 μM for HDAC1, 0.591 μM for HDAC2, 3.552 μM for HDAC3, and 0.459 μM for HDAC6. The compound induces G2 phase cell cycle arrest and promotes apoptosis. It effectively hampers the proliferation of both hematoma and solid tumor cells, diminishes tumor metastasis, and demonstrates tumor growth inhibition in a liver tumor allograft mouse model [1].
价 格：￥电议型 号：T79452产 地：中国大陆
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T79451WES-1；化合物 WES-1WES-1
WES-1 (Compound 8g), a carbonic anhydrase IX inhibitor (Ki: 55.9 μM), exhibits broad-spectrum antiproliferative activity against various cancer cell lines, including leukemia (K-562 and MOLT-4), non-small cell lung cancer (NCI-H460), colon cancer (HCT 116 and HCT-15), and melanoma (LOX IMVI) [1].
价 格：￥电议型 号：T79451产 地：中国大陆
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T79450Enzyme-IN-2；化合物 Enzyme-IN-2Enzyme-IN-2
Enzyme-IN-2 (compound 15) serves as a potent urease inhibitor, exhibiting anti-ureolytic activity with a K i of 2.36 ?M and an IC 50 of 0.75 ?M [1].
价 格：￥电议型 号：T79450产 地：中国大陆
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T7945SU14813；化合物SU14813SU14813
SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT).
价 格：￥电议型 号：T7945产 地：中国大陆
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T79449Antileishmanial agent-19；化合物 Antileishmanial agent-19Antileishmanial agent-19
Compound F27 (Antileishmanial agent-19) is an antileishmanial compound effective against L. donovani promastigotes, demonstrating an IC50 of 3.39 μM. It functions by inhibiting the Leishmania prolyl-tRNA synthetase and disrupting the host PI3K/Akt/CREB axis-mediated IL-10 secretion. Additionally, Compound F27 promotes autophagy-mediated apoptosis in L. donovani promastigotes and has been shown to reduce parasite burden in L.d-infected animals [1].
价 格：￥电议型 号：T79449产 地：中国大陆
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T79448IRAK4-IN-26；化合物 IRAK4-IN-26IRAK4-IN-26
IRAK4-IN-26 (Compound 21), an IRAK4 inhibitor with an IC50 of 6.2 nM, exhibits an oral bioavailability of 21%. It is utilized for the study of inflammatory and autoimmune disorders [1].
价 格：￥电议型 号：T79448产 地：中国大陆
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T79447IRAK4-IN-25；化合物 IRAK4-IN-25IRAK4-IN-25
IRAK4-IN-25 (compound 38), a potent oral IRAK4 inhibitor (IC50 = 7.3 nM) with low clearance (Cl = 12 mL/min/kg), effectively suppresses pro-inflammatory cytokine production and demonstrates favorable in vitro safety and ADME profiles. It is suitable for research on inflammatory and autoimmune disorders [1].
价 格：￥电议型 号：T79447产 地：中国大陆
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T79446INF200；化合物 INF200INF200
INF200 (compound 5), a sulfonylurea-based inhibitor of NLRP3 and associated pyroptosis, exhibits cardiometabolic benefits in a rat model of high-fat diet (HFD)-induced metaflammation and demonstrates anti-inflammatory effects by reducing IL-1β release in human macrophages at a concentration of 10 μM. Additionally, it enhances glucose and lipid profiles, diminishes systemic inflammation and cardiac dysfunction biomarkers, notably BNP, and ameliorates myocardial damage linked to ischemia/reperfusi
价 格：￥电议型 号：T79446产 地：中国大陆
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T79445KV1.3-IN-1；化合物 KV1.3-IN-1KV1.3-IN-1
KV1.3-IN-1 (Compound trans-18), a selective KV1.3 channel inhibitor with IC50 values of 230 nM in Ltk cells and 26.12 nM in PHA-activated T-lymphocytes, disrupts intracellular Ca2+ signaling and impedes T-cell activation and proliferation, as well as colony formation [1].
价 格：￥电议型 号：T79445产 地：中国大陆
