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  • T79408KGP591；化合物 KGP591KGP591

    KGP591, a tubulin polymerization inhibitor with an IC50 of 0.57 ?M, effectively induces G2/M arrest, inhibits cell migration, and disrupts microtubule structure and cell morphology in MDA-MB-231 cells. Additionally, it demonstrates antitumor activity in an orthotopic kidney cancer model (RENCA) [1].

    价 格：￥电议型 号：T79408产 地：中国大陆

  • T79407HL23；化合物 HL23HL23

    HL23 is a histone deacetylase (HDAC) inhibitor that effectively targets hepatocellular carcinoma (HCC). It promotes acetylation at the TXNIP promoter and increases TXNIP expression, which in turn modulates potassium channel activity and induces TXNIP-dependent potassium deficiency. Additionally, HL23 impedes the advancement and spread of HCC and demonstrates a synergistic effect when combined with Sorafenib, exhibiting greater potency than the duo of Sorafenib and Vorinostat [1].

    价 格：￥电议型 号：T79407产 地：中国大陆

  • T79406Tyrosinase-IN-14；化合物 Tyrosinase-IN-14Tyrosinase-IN-14

    Tyrosinase-IN-14 (compound 7m), a tyrosinase inhibitor, modulates the enzyme´s secondary structure to diminish its catalytic function, exhibits low cytotoxicity, and possesses anti-browning properties that effectively prevent banana discoloration during storage [1].

    价 格：￥电议型 号：T79406产 地：中国大陆

  • T79405PARP1-IN-15；化合物 PARP1-IN-15PARP1-IN-15

    PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis. It exhibits anti-cancer activity in triple-negative breast cancer (TNBC) cells and patient-derived organoids, making it useful for TNBC research, including cases with or without BRCA1 mutations [1].

    价 格：￥电议型 号：T79405产 地：中国大陆

  • T79404A09-003；化合物 A09-003A09-003

    A09-003 is a novel cell cycle protein-dependent kinase-9 CDK-9 inhibitor.A09-003 inhibits the proliferation of a variety of leukemia cell lines and inhibits the increase of leukemia sequence-1 protein in myeloid cells.A09-003 also induces apoptosis, decreases RNA polymerase II activity, and decreases Mcl-1 expression.

    价 格：￥电议型 号：T79404产 地：中国大陆

  • T79403VEGFR-2-IN-36；化合物 VEGFR-2-IN-36VEGFR-2-IN-36

    VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstrated anticancer efficacy. It modulates apoptotic pathways by upregulating BAX and downregulating Bcl-2, leading to cytotoxic effects on cancer cell lines, including MCF-7 (IC50 = 0.42 μM) and HepG2 (IC50 = 0.22 μM) [1].

    价 格：￥电议型 号：T79403产 地：中国大陆

  • T79402α-Amylase/α-Glucosidase-IN-4；化合物 α-Amylase/α-Glucosidase-IN-4α-Amylase/α-Glucosidase-IN-4

    α-Amylase/α-Glucosidase-IN-4 (compound 5), a dual inhibitor targeting α-amylase (Amylases) and α-glucosidase (Glucosidase), exhibits potent inhibition with IC50 values of 1.10 μM and 0.15 μM respectively. This compound is noted for its potential antidiabetic activity [1].

    价 格：￥电议型 号：T79402产 地：中国大陆

  • T79401Tyrosinase-IN-13；化合物 Tyrosinase-IN-13Tyrosinase-IN-13

    Tyrosinase-IN-13 (compound 3c), stemming from Flurbiprofen, acts as a potent non-competitive inhibitor of tyrosinase, exhibiting IC50 and Ki values of 68 μM and 36.3 μM respectively. This compound demonstrates cytotoxicity against several cancer cell lines, including hepatocellular carcinoma (HepG2), colorectal cancer (HT-29), and melanoma (B16F10) [1].

    价 格：￥电议型 号：T79401产 地：中国大陆

  • T79400VEGFR-2-IN-35；化合物 VEGFR-2-IN-35VEGFR-2-IN-35

    VEGFR-2-IN-35 (compound 7) is a potent inhibitor of VEGFR-2, exhibiting an IC50 of 37 nM. Additionally, it demonstrates inhibitory activity against MCF-7 and HCT 116 cancer cell lines with IC50 values of 10.56 μM and 7.07 μM, respectively [1].

    价 格：￥电议型 号：T79400产 地：中国大陆

  • T7940Milnacipran ((1S-cis) hydrochloride)；左旋米那普林Levomilnacipran Hydrochloride；左旋米那普林|||Levomilnacipran Hy

    Milnacipran (1S-cis) hydrochloride (Levomilnacipran Hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI), treatment of fibromyalgia.

    价 格：￥电议型 号：T7940产 地：中国大陆

  • T78794α-Glucosidase-IN-31；化合物 α-Glucosidase-IN-31α-Glucosidase-IN-31

    α-Glucosidase-IN-31 (compound R1) is a potent oral α-Glucosidase inhibitor with an IC50 of 10.1 μM, demonstrating significant blood glucose reduction and antidiabetic activity [1].

    价 格：￥电议型 号：T78794产 地：中国大陆

  • T77949Thalidomide-5-O-C2-NH2 hydrochloride；化合物 Thalidomide-5-O-C2-NH2 hydrochlorideThalidomide-5-O-C2-NH2

    Thalidomide-5-O-C2-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated via a linker to form PROTACs [1].

    价 格：￥电议型 号：T77949产 地：中国大陆

  • T77948Tri-GalNAc-DBCO；化合物 Tri-GalNAc-DBCOTri-GalNAc-DBCO

    Tri-GalNAc-DBCO, a compound with high affinity for the hepatocyte-specific asialoglycoprotein receptor (ASGPR), can bind to this receptor, facilitating targeted protein downregulation and degradation [1].

    价 格：￥电议型 号：T77948产 地：中国大陆

  • T77947Tri-GalNAc(OAc)3 TFA；化合物 Tri-GalNAc(OAc)3 TFATri-GalNAc(OAc)3 TFA

    Tri-GalNAc(OAc)3 TFA, a triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand, is utilized in the synthesis of GalNAc-lysosome-targeting chimera (GalNAc-LYTAC). This compound facilitates targeted protein degradation by engaging with the asialoglycoprotein receptor [1].

    价 格：￥电议型 号：T77947产 地：中国大陆

  • T77946Tri-GalNAc(OAc)3；化合物 Tri-GalNAc(OAc)3Tri-GalNAc(OAc)3

    Tri-GalNAc(OAc)3, a triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand, is utilized in the synthesis of GalNAc-lysosome targeting chimeras (LYTAC). These chimeras exploit the asialoglycoprotein receptor to direct protein degradation targets to the lysosome [1].

    价 格：￥电议型 号：T77946产 地：中国大陆

  • T77945TriGalNAc CBz；化合物 TriGalNAc CBzTriGalNAc CBz

    TriGalNAc CBz is a GalNAc derivative. As an ASGPR ligand, tri-GalNAc targets lysosomes in mRNA drug delivery and LYTAC studies.L-DABA hydrobromide.

    价 格：￥电议型 号：T77945产 地：中国大陆

  • T77944SJ1008030 formic；化合物 SJ1008030 formicSJ1008030 formic

    SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with an IC50 value of 5.4 nM. It is potentially applicable for leukemia research [1].

    价 格：￥电议型 号：T77944产 地：中国大陆

  • T77943SJ1008030 TFA；化合物 SJ1008030 TFASJ1008030 TFA

    SJ1008030 (compound 8) TFA is a selective JAK2-degrading PROTAC that inhibits the growth of MHH-CALL-4 leukemia cells with an IC50 of 5.4 nM, indicating its potential use for leukemia research [1].

    价 格：￥电议型 号：T77943产 地：中国大陆

  • T77942SIAIS164018 hydrochloride；化合物 SIAIS164018 hydrochlorideSIAIS164018 hydrochloride

    SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R. It effectively suppresses cancer cell migration and invasion, induces G1 cell cycle arrest, and promotes apoptosis, demonstrating superior properties compared to Brigatinib [1].

    价 格：￥电议型 号：T77942产 地：中国大陆

  • T77941tri-GalNAc biotin；化合物 tri-GalNAc biotintri-GalNAc biotin

    Tri-GalNAc biotin, a small molecule lysosome targeting degrader, serves as a ligand for the asialoglycoprotein receptor (ASGPR). It promotes the uptake of NeutrAvidin (NA) into liver cells via ASGPR and directs NeutrAvidin to the lysosome for degradation. This compound is applicable in the study of Lysosome Targeting Chimeras (LYTAC) [1].

    价 格：￥电议型 号：T77941产 地：中国大陆

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