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T7587LTenapanor HCl;化合物 T7587LRDX-5791|||AZD 1722|||AZD-1722|||AZD1722|||RDX5791|||RDX 5791;RDX-5791|||AZD
Tenapanor( AZD-1722, RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which is used for sodium handling in the gastrointestinal tract and kidney.
价 格:¥电议型 号:T7587L产 地:中国大陆
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T75879Men 10376 TFA;化合物 Men 10376 TFAMen 10376 TFA
Men 10376 TFA is a selective antagonist of the tachykinin NK-2 receptor, displaying a K i value of 4.4 μM specifically for the NK-2 receptor in rat small intestine [1].
价 格:¥电议型 号:T75879产 地:中国大陆
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T75878Catestatin TFA;化合物 Catestatin TFACatestatin TFA
Catestatin TFA, a 21-amino acid residue peptide, exhibits both cationic and hydrophobic properties. This endogenous peptide plays a crucial role in regulating cardiac function and blood pressure. It functions as a non-competitive nicotinic antagonist by interacting with nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release.
价 格:¥电议型 号:T75878产 地:中国大陆
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T75877α-Conotoxin AuIB TFA;化合物 α-Conotoxin AuIB TFAα-Conotoxin AuIB TFA
α-Conotoxin AuIB TFA, a potent selective antagonist of the α3β4 nicotinic acetylcholine receptor (nAChR), effectively inhibits nAChRs expressed in Xenopus oocytes, demonstrating an inhibitory concentration (IC 50) of 0.75 μM [1].
价 格:¥电议型 号:T75877产 地:中国大陆
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T75876α-Conotoxin PIA TFA;化合物 α-Conotoxin PIA TFAα-Conotoxin PIA TFA
α-Conotoxin PIA TFA, targeting nicotinic acetylcholine receptor (nAChR) subtypes with α6 and α3 subunits, acts as an antagonist. This compound shows promise for research into Parkinson’s disease and schizophrenia [1].
价 格:¥电议型 号:T75876产 地:中国大陆
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T75875α-Conotoxin PnIA TFA;化合物 α-Conotoxin PnIA TFAα-Conotoxin PnIA TFA
α-Conotoxin PnIA TFA, a potent and selective antagonist of the mammalian α7 nAChR, holds promise for neurological research, particularly in studying neuropathic pain and Alzheimer´s disease [1].
价 格:¥电议型 号:T75875产 地:中国大陆
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T75874tcY-NH2 TFA;化合物 tcY-NH2 TFAtcY-NH2 TFA
tcY-NH2 (trans-Cinnamoyl)-YPGKF-NH2) TFA is a selective PAR4 antagonist peptide with potent properties. It effectively inhibits thrombin- and AY-NH2-induced platelet aggregation and endostatin release. This compound finds utility in inflammation and immunology research [1] [2] [6].
价 格:¥电议型 号:T75874产 地:中国大陆
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T75873Parstatin(human) TFA;化合物 Parstatin(human) TFAParstatin(human) TFA
Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, effectively inhibits angiogenesis, as indicated by studies [1] [2].
价 格:¥电议型 号:T75873产 地:中国大陆
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T75872Parstatin(mouse) TFA;化合物 Parstatin(mouse) TFAParstatin(mouse) TFA
Parstatin(mouse) TFA, a cell-penetrating agonist peptide of the PAR-1 thrombin receptor, effectively inhibits angiogenesis [1] [2].
价 格:¥电议型 号:T75872产 地:中国大陆
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T75871FSLLRY-NH2 TFA;化合物 FSLLRY-NH2 TFAFSLLRY-NH2 TFA
FSLLRY-NH2 TFA is a protease-activated receptor 2 (PAR2) inhibitor [1] .
价 格:¥电议型 号:T75871产 地:中国大陆
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T75870PR-39 TFA;化合物 PR-39 TFAPR-39 TFA
PR-39 TFA, a natural peptide rich in proline and arginine with antibacterial properties, acts as a noncompetitive, reversible, and allosteric inhibitor of the proteasome. It specifically attaches to the α7 subunit of the proteasome, preventing the degradation of the NF-κB inhibitor IκBα through the ubiquitin-proteasome pathway. Additionally, PR-39 TFA promotes angiogenesis, suppresses inflammatory responses, and notably decreases myocardial infarct size in mice [1] [2].
价 格:¥电议型 号:T75870产 地:中国大陆
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T7587Tenapanor;化合物TenapanorRDX-5791|||RDX 5791|||AZD 1722|||Tenapanor free base|||RDX5791|||AZD-1722|||AZ
Tenapanor (RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. Tenapanor possesses an excellent preclinical safety profile and, as of now, there are no serious concerns about its side effects.
价 格:¥电议型 号:T7587产 地:中国大陆
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T75869PSI TFA;化合物 PSI TFAPSI TFA
PSI (TFA) is a potent proteasome inhibitor effective against the proliferation of primary effusion lymphoma (PEL) cells, utilized in the study of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and related lymphomas [1].
价 格:¥电议型 号:T75869产 地:中国大陆
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T75868JMV 449 acetate;JMV 449 acetateJMV 449 acetate
JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC 50 of 0.15 nM for inhibition of 125 I-neurotensin binding to neonatal mouse brain and an EC 50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse [1] [2] .
价 格:¥电议型 号:T75868产 地:中国大陆
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T75867Parathyroid Hormone (1-34), bovine TFA;化合物 Parathyroid Hormone (1-34), bovine TFAParathyroid Hormone
Parathyroid Hormone (1-34), bovine TFA, a potent agonist of the parathyroid hormone (PTH) receptor, elevates calcium and inorganic phosphate levels in vivo. This compound is employed in osteoporosis research [1].
价 格:¥电议型 号:T75867产 地:中国大陆
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T75866RFRP-3(human) TFA;化合物 RFRP-3(human) TFARFRP-3(human) TFA
RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human homolog of the GnIH peptide, significantly suppresses gonadotropin release through inhibition of Ca 2+ mobilization. Acting as an NPFF1 receptor agonist, RFRP-3 (human) also blocks forskolin-stimulated cAMP production, achieving an inhibition concentration (IC 50) of 0.7 nM [1].
价 格:¥电议型 号:T75866产 地:中国大陆
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T75865Neuropeptide SF(mouse,rat) TFA;化合物 Neuropeptide SF(mouse,rat) TFANeuropeptide SF(mouse,rat) TFA
Neuropeptide SF (mouse, rat) TFA, a potent agonist for neuropeptide FF receptors, exhibits K_i values of 48.4 nM for NPFF1 and 12.1 nM for NPFF2. Additionally, this compound enhances the amplitude of the sustained current in heterologously expressed acid-sensing ion channel 3 (ASIC3) [1].
价 格:¥电议型 号:T75865产 地:中国大陆
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T75864Calcineurin autoinhibitory peptide TFA;化合物 Calcineurin autoinhibitory peptide TFACalcineurin autoinh
Calcineurin Autoinhibitory Peptide TFA is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), exhibiting an inhibitory concentration (IC50) of approximately 10 μM. This compound has been shown to protect neurons from excitatory neuronal death [1] [2].
价 格:¥电议型 号:T75864产 地:中国大陆
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T75863Secretin (33-59), rat TFA;化合物 Secretin (33-59), rat TFASecretin (33-59), rat TFA
Secretin (33-59), rat (TFA), a 27-amino acid peptide, targets the secretin receptor to increase the release of bicarbonate, enzymes, and potassium (K+) from the pancreas [1] [2].
价 格:¥电议型 号:T75863产 地:中国大陆
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T75862BAM(8-22) TFA;化合物 BAM(8-22) TFABAM(8-22) TFA
BAM(8-22) TFA, a proteolytically cleaved fragment of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), specifically MrgprC11 and hMrgprX1. It induces scratching in mice through an Mrgpr-dependent pathway [1].
价 格:¥电议型 号:T75862产 地:中国大陆