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  • T38835STK33-IN-1STK33-IN-1STK33-IN-1

    STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC 50 of 7 nM.

    价 格：￥电议型 号：T38835产 地：中国大陆

  • T38834LYP-IN-1；LYP-IN-1LYP-IN-1

    LYP-IN-1 is a powerful LYP inhibitor that demonstrates high potency, selectivity, and specificity, with a Ki of 110 nM and an IC 50 of 0.259 μM. Beyond its primary target, LYP-IN-1 also exhibits selectivity towards a wide range of PTPs, including SHP1 (IC 50 = 5 μM) and SHP2 (IC 50 = 2.5 μM). Additionally, LYP-IN-1 demonstrates remarkable efficacy in T- and mast cells, making it a valuable tool for investigating autoimmune disorders.

    价 格：￥电议型 号：T38834产 地：中国大陆

  • T38775LeuRS-IN-1；LeuRS-IN-1LeuRS-IN-1

    LeuRS-IN-1 is a highly potent and orally active inhibitor of the leucyl-tRNA synthetase enzyme derived from Mycobacterium tuberculosis (M.tb LeuRS). It exhibits significant inhibitory activity against M.tb LeuRS with IC 50 and Kd values of 0.06 μM and 0.075 μM, respectively. Additionally, LeuRS-IN-1 effectively inhibits human cytoplasmic LeuRS with an IC 50 value of 38.8 μM and suppresses protein synthesis in HepG2 cells with an EC 50 value of 19.6 μM.

    价 格：￥电议型 号：T38775产 地：中国大陆

  • T38773LeuRS-IN-1 hydrochloride；LeuRS-IN-1 hydrochlorideLeuRS-IN-1 hydrochloride

    LeuRS-IN-1 hydrochloride is a potent and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS). It has IC 50 and Kd values of 0.06 μM and 0.075 μM, respectively, for M.tb LeuRS. Additionally, LeuRS-IN-1 hydrochloride inhibits human cytoplasmic LeuRS with an IC 50 of 38.8 μM and HepG2 protein synthesis with an EC 50 of 19.6 μM.

    价 格：￥电议型 号：T38773产 地：中国大陆

  • T38770Guanylate cyclase-IN-1；Guanylate cyclase-IN-1Guanylate cyclase-IN-1

    Guanylate cyclase-IN-1 (Example 46) is a specific inhibitor of guanylate cyclase, employed in research related to cardiovascular diseases.

    价 格：￥电议型 号：T38770产 地：中国大陆

  • T38765UBE2T/FANCL-IN-1；UBE2T/FANCL-IN-1UBE2T/FANCL-IN-1；UBE2T/FANCL-IN-1

    UBE2T/FANCL-IN-1 is a highly effective inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation. It greatly enhances the sensitivity of cells to Carboplatin, a DNA cross-linking agent.

    价 格：￥电议型 号：T38765产 地：中国大陆

  • T38584ALK-IN-12；ALK-IN-12ALK-IN-12

    ALK-IN-12 is a highly potent and orally active inhibitor of anaplastic lymphoma kinase (ALK), demonstrating an exceptional IC50 value of 0.18 nM. Additionally, ALK-IN-12 displays inhibitory activity against insulin-like growth factor 1 receptor (IGF1R) and insulin receptor (InsR), with IC50 values of 20.3 nM and 90.6 nM, respectively. Notably, its antitumor effects have been observed, making it a promising compound for targeted cancer therapy.

    价 格：￥电议型 号：T38584产 地：中国大陆

  • T38583ALK-IN-13；ALK-IN-13ALK-IN-13

    ALK-IN-13 is an ALK inhibitor.

    价 格：￥电议型 号：T38583产 地：中国大陆

  • T38436JAK-2/3-IN-1；JAK-2/3-IN-1JAK-2/3-IN-1

    JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms. It exhibits remarkable potency, with Ki values below 250 nM for both isoforms.

    价 格：￥电议型 号：T38436产 地：中国大陆

  • T38421PRMT1-IN-1PRMT1-IN-1PRMT1-IN-1

    PRMT1-IN-1 is a PRMT1 inhibitor.

    价 格：￥电议型 号：T38421产 地：中国大陆

  • T38420GCPII-IN-1；GCPII-IN-1GCPII-IN-1

    GCPII-IN-1 is a potent inhibitor scaffold targeting glutamate carboxypeptidase II (GCPII), also known as prostate-specific membrane antigen (PSMA). It exhibits a high affinity for GCPII, with a binding affinity (K i ) of 44.3 nanomolar (nM).

    价 格：￥电议型 号：T38420产 地：中国大陆

  • T38310Luciferase-IN-1；荧光素酶-IN-1Luciferase-IN-1

    Luciferase-IN-1 is a luciferase inhibitor that can be used to study bacterial and fungal infections.

    价 格：￥电议型 号：T38310产 地：中国大陆

  • T38234HCoV-229E-IN-1；HCoV-229E-IN-1HCoV-229E-IN-1

    HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, demonstrating efficacy with an EC50 value of 0.65 μM in MTS cells and 0.6 μM in CPE cells[1].

    价 格：￥电议型 号：T38234产 地：中国大陆

  • T38168S.pombe lumazine synthase-IN-1；S.pombe lumazine synthase-IN-1S.pombe lumazine synthase-IN-1

    S.pombe lumazine synthase-IN-1 is a compound that inhibits lumazine synthases, demonstrating Ki values of 243 μM for Schizosaccharomyces pombe and 9.6 μM for Mycobacterium tuberculosis, respectively[1].

    价 格：￥电议型 号：T38168产 地：中国大陆

  • T38078TLR7/8-IN-1；化合物TLR7/8-IN-1TLR7/8-IN-1；TLR7/8-IN-1

    TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research[1].

    价 格：￥电议型 号：T38078产 地：中国大陆

  • T37824MCT4-IN-1；MCT4-IN-1MCT4-IN-1；MCT4-IN-1

    MCT4-IN-1 is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MCT4-IN-1 targets to the cytosolic domain of MCT4. MCT4-IN-1 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MCT4-IN-1 has the potential for MCT4 transporter inhibition research[1].

    价 格：￥电议型 号：T37824产 地：中国大陆

  • T37696NOS1-IN-1；NOS1抑制剂1nNOS Inhibitor I；nNOS Inhibitor I

    NOS1-IN-1（nNOS Inhibitor I） is a potent, selective and cell permeable nNOS inhibitor (Ki: 120 nM).NOS1-IN-1 has a Ki value of 39 μM for eNOS and 325 μM for iNOS.NOS1-IN-1 can be used for the study of neurological disorders such as cerebral palsy.

    价 格：￥电议型 号：T37696产 地：中国大陆

  • T37657Mitochondrial respiration-IN-1 hydrobromide；Mitochondrial respiration-IN-1 hydrobromideMitochondrial

    Mitochondrial respiration-IN-1 hydrobromide (compound 49) is a potent mitochondrial inhibitor (IC50=8.8 mg/mL). Mitochondrial respiration-IN-1 hydrobromide significantly reduces mitochondrial respiration in platelets[1].

    价 格：￥电议型 号：T37657产 地：中国大陆

  • T37356Cbl-b-IN-1；Cbl-b抑制剂1Cbl-b-IN-1

    Cbl-b-IN-1 is a potent Cbl-b inhibitor (IC50 <100 nM) with potential anticancer activity for the study of intestinal inflammation.

    价 格：￥电议型 号：T37356产 地：中国大陆

  • T37174SARS-CoV MPro-IN-1MPro Inhibitor 11bSARSCoV MProIN1|||SARS CoV MPro IN 1

    MProinhibitor 11b is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.04 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50= 0.72 μM). MProinhibitor 11b also reduces viral RNA copy numbers in the same model when used at concentrations ranging from 1.85 to 50 μM.

    价 格：￥电议型 号：T37174产 地：中国大陆

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