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T8744PROTAC BRAF-V600E degrader-2；化合物 T8744PROTAC BRAF-V600E degrader-2
PROTAC BRAF-V600E degrader-2 is a useful organic compound for research related to life sciences. The catalog number is T8744 and the CAS number is 2417296-82-1.
价 格：￥电议型 号：T8744产 地：中国大陆
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T83947HDAC4 CHDI Degrader 11；化合物 HDAC4 CHDI Degrader 11HDAC4 CHDI Degrader 11
HDAC4 CHDI Degrader 11 is a potent, selective degrader of HDAC4 (PROTAC) with DC_50 values of 4 nM and 6 nM in Jurkat E6-1 and Jurkat cells, respectively. This compound integrates the class IIa HDAC inhibitor trifluoromethyloxadiazole with a ligand for the Von Hippel-Lindau (VHL) protein through a linker. Demonstrating significant efficacy, HDAC4 CHDI Degrader 11 achieves a DC_50 value of 1 nM in a mouse cell model of Huntington´s disease. For enhanced degradation in neuroblastoma cell lin
价 格：￥电议型 号：T83947产 地：中国大陆
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T82821BRD9 Degrader-1；化合物 BRD9 Degrader-1BRD9 Degrader-1
BRD9 Degrader-1 functions as a BRD9 degrader, demonstrating micromolar binding affinity towards BRD9 and nanomolar affinity for the ternary complex involving BRD9 and VCB [1].
价 格：￥电议型 号：T82821产 地：中国大陆
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T82253GSPT1 degrader-2；化合物 GSPT1 degrader-2GSPT1 degrader-2
GSPT1 degrader-2 is a potent degrader of GSPT1 [1].
价 格：￥电议型 号：T82253产 地：中国大陆
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T81386PROTAC BRD4 Degrader-22；化合物 PROTAC BRD4 Degrader-22PROTAC BRD4 Degrader-22
PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based degrader targeting BRD4, exhibiting a pDC50 of 9.2 in MOLT4 cells over 24 hours [1].
价 格：￥电议型 号：T81386产 地：中国大陆
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T81385PROTAC BRD9 Degrader-2；化合物 PROTAC BRD9 Degrader-2PROTAC BRD9 Degrader-2
PROTAC BRD9 Degrader-2 is a bifunctional compound designed for the targeted degradation of BRD9 in cancer research applications.
价 格：￥电议型 号：T81385产 地：中国大陆
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T81384PROTAC BRD9 Degrader-3；化合物 PROTAC BRD9 Degrader-3PROTAC BRD9 Degrader-3
PROTAC BRD9 Degrader-3 is a bifunctional degrader targeting BRD9, utilized in cancer research.
价 格：￥电议型 号：T81384产 地：中国大陆
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T81383PROTAC BRD9 Degrader-5；化合物 PROTAC BRD9 Degrader-5PROTAC BRD9 Degrader-5
PROTAC BRD9 Degrader-5 is a proteolysis targeting chimera (PROTAC) designed for the specific degradation of Bromodomain-containing protein 9 (BRD9).
价 格：￥电议型 号：T81383产 地：中国大陆
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T81382PROTAC BRD9 Degrader-7；化合物 PROTAC BRD9 Degrader-7PROTAC BRD9 Degrader-7
PROTAC BRD9 Degrader-7 is a selective and orally active BRD9 degrader with a DC50 of 1.02 nM and demonstrates superior pharmacokinetics, evidenced by a Cmax of 3436.95 ng/mL [1].
价 格：￥电议型 号：T81382产 地：中国大陆
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T81381PROTAC eDHFR Degrader-1；化合物 PROTAC eDHFR Degrader-1PROTAC eDHFR Degrader-1
PROTAC eDHFR Degrader-1 is a potent degrader targeting eDHFR-YFP and various proteins of interest (POIs), such as YFP and Luciferase [1].
价 格：￥电议型 号：T81381产 地：中国大陆
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T81380PROTAC EGFR degrader 7 diTFA；化合物 PROTAC EGFR degrader 7 diTFAPROTAC EGFR degrader 7 diTFA
PROTAC EGFR degrader 7 (compound 13b) is a potent, selective, CRBN-recruiting EGFRL858R/T790M degrader with a DC50 of 13.2 nM. It effectively inhibits proliferation of NCI-H1975 cells with an IC50 of 46.82 nM, induces apoptosis, and causes a G2/M phase arrest in these cells. Demonstrating antitumor activity, this compound is applicable in non-small cell lung cancer (NSCLC) research.
价 格：￥电议型 号：T81380产 地：中国大陆
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T81379PROTAC GDI2 Degrader-1；化合物 PROTAC GDI2 Degrader-1PROTAC GDI2 Degrader-1
PROTAC GDI2 Degrader-1 (Compound 21) is a potent degrader of PROTAC GDI2, demonstrating outstanding antitumor activity in vivo within pancreatic xenograft models that overexpress GDI2 [1].
价 格：￥电议型 号：T81379产 地：中国大陆
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T81377PROTAC NSD3 degrader-1；化合物 PROTAC NSD3 degrader-1PROTAC NSD3 degrader-1
PROTAC NSD3 degrader-1 (compound 56) is a targeted degradation agent for the Nuclear receptor binding SET domain protein NSD3. It effectively induces the degradation of NSD3 in NCI-H1703 and A549 lung cancer cell lines, with DC50 values of 1.43 and 0.94 μM, respectively. Additionally, it hinders H3K36 methylation, triggers apoptosis, and arrests the cell cycle. Furthermore, PROTAC NSD3 degrader-1 diminishes the expression of NSD3-related genes, including CDC25A, ALDH1A1, and IGFBP.
价 格：￥电议型 号：T81377产 地：中国大陆
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T81376PROTAC SMARCA2 degrader-2；化合物 PROTAC SMARCA2 degrader-2PROTAC SMARCA2 degrader-2
PROTAC SMARCA2 degrader-2, a selective and powerful degrader of SMARCA2/4, exhibits an IC50 of <0.1 μΜ in the HeLa HiBiT assay.this compound holds promise for research into cancers related to or deficient in SMARCA4 [1].
价 格：￥电议型 号：T81376产 地：中国大陆
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T81375PROTAC TTK degrader-1；化合物 PROTAC TTK degrader-1PROTAC TTK degrader-1
PROTAC TTK degrader-1, a potent threonine tyrosine kinase (TTK) PROTAC degrader, demonstrates DC50 values of 1.7 nM in COLO-205 cells and 5.8 nM in HCT-116 cells, indicating effective target degradation. Furthermore, it shows anticancer efficacy in a xenograft mouse model with COLO-205 human colorectal cancer cells [1].
价 格：￥电议型 号：T81375产 地：中国大陆
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T81374PROTAC TTK degrader-2；化合物 PROTAC TTK degrader-2PROTAC TTK degrader-2
PROTAC TTK Degrader-2 is a potent threonine tyrosine kinase (TTK) PROTAC degrader, achieving DC50 values of 3.1 nM in COLO-205 cells and 12.4 nM in HCT-116 cells. It demonstrates effective target degradation and anticancer activity in a COLO-205 human colorectal cancer cell xenograft mouse model [1].
价 格：￥电议型 号：T81374产 地：中国大陆
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T80647Androgen receptor degrader-2；化合物 Androgen receptor degrader-2Androgen receptor degrader-2
Androgen Receptor Degrader-2 (Compound 9) is a potent degrader of androgen receptors, with potential application in cancer research [1].
价 格：￥电议型 号：T80647产 地：中国大陆
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T80633Androgen receptor degrader-1；化合物 Androgen receptor degrader-1Androgen receptor degrader-1
Androgen Receptor Degrader-1 (Compound 18) is a potent agent for androgen receptor degradation, applicable in cancer research [1].
价 格：￥电议型 号：T80633产 地：中国大陆
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T79904PROTAC CDK9/CycT1 Degrader-2；化合物 PROTAC CDK9/CycT1 Degrader-2PROTAC CDK9/CycT1 Degrader-2
PROTAC CDK9/CycT1 Degrader-2 inhibits CDK9 with an IC50 of 45 nM [1].
价 格：￥电议型 号：T79904产 地：中国大陆
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T79891Androgen receptor degrader-3；化合物 Androgen receptor degrader-3Androgen receptor degrader-3
Androgen Receptor Degrader-3 (ARD-3) is a compound that inhibits androgen receptor signaling and promotes the degradation of the receptor, with potential applications in prostate cancer research [1].
价 格：￥电议型 号：T79891产 地：中国大陆
