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T63922ERα degrader 5；化合物 ERα degrader 5ERα degrader 5
ERα degrader 5 is an orally active, selective estrogen receptor (ER) reducer that acts on ERα (EC50: 1.1 nM). ERα degrader 5 shows anti-tumour effects in vivo.
价 格：￥电议型 号：T63922产 地：中国大陆
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T63675ER degrader 1；化合物 ER degrader 1ER degrader 1
ER degrader 1 is a potent degrader of the estrogen receptor (ER). The estrogen signaling system plays an important role in the regulation of cell growth, differentiation and apoptosis, and ER degrader 1 has shown potential for cancer diseases.
价 格：￥电议型 号：T63675产 地：中国大陆
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T60416CRM1 degrader 1；化合物 CRM1 degrader 1CRM1 degrader 1
CRM1 degrader 1 (1l) is a low-toxic CRM1 degrader that induces apoptosis in gastric carcinoma and selectively inhibits the proliferation of gastric cancer[1].
价 格：￥电议型 号：T60416产 地：中国大陆
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T5439BRD4 degrader AT1；化合物BRD4 degrader AT1BRD4 degrader AT1
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
价 格：￥电议型 号：T5439产 地：中国大陆
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T5438PROTAC CDK9 Degrader-1；化合物PROTAC CDK9 Degrader-1PROTAC CDK9 Degrader-1
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
价 格：￥电议型 号：T5438产 地：中国大陆
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T4207(S,R,S)-AHPC hydrochloride；化合物Protein degrader 1 hydrochlorideVHL Ligand 1 hydrochloride|||ULM-1|||P
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
价 格：￥电议型 号：T4207产 地：中国大陆
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T40250SHP2 protein degrader-1；SHP2 protein degrader-1SHP2 protein degrader-1；SHP2 protein degrader-1
SHP2 protein degrader-1 is a highly efficient allosteric inhibitor targeting SHP2. It effectively induces degradation of SHP2 protein, resulting in cell apoptosis. This compound shows promising potential for studying diseases associated with SHP2.
价 格：￥电议型 号：T40250产 地：中国大陆
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T40143PROTAC CBP/P300 Degrader-1；PROTAC CBP/P300 Degrader-1PROTAC CBP/P300 Degrader-1；PROTAC CBP/P300 Degr
PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.
价 格：￥电议型 号：T40143产 地：中国大陆
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T40112PROTAC PD-1/PD-L1 degrader-1；PROTAC PD-1/PD-L1 degrader-1PROTAC PD-1/PD-L1 degrader-1；PROTAC PD-1/PD
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
价 格：￥电议型 号：T40112产 地：中国大陆
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T40075PROTAC BRD4 Degrader-13；PROTAC BRD4 Degrader-13PROTAC BRD4 Degrader-13；PROTAC BRD4 Degrader-13
PROTAC BRD4 Degrader-13 (compound 9d) is a bioactive compound that functions as a proteolysis targeting chimera (PROTAC), linking ligands for von Hippel-Lindau and BRD4 proteins. In the context of PC3 prostate cancer cells, this compound effectively degrades the BRD4 protein through conjugation with STEAP1 and CLL1 antibodies. The degradation of BRD4 protein is achieved with remarkable potency, exhibiting a DC 50 of 0.025 nM and 6.0 nM when combined with STEAP1 and CLL1 antibodies, respectively.
价 格：￥电议型 号：T40075产 地：中国大陆
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T40074PROTAC BRD4 Degrader-15；PROTAC BRD4 Degrader-15PROTAC BRD4 Degrader-15；PROTAC BRD4 Degrader-15
PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2. Additionally, PROTAC BRD4 Degrader-15 demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells.
价 格：￥电议型 号：T40074产 地：中国大陆
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T40073PROTAC BRD4 Degrader-10；PROTAC BRD4 Degrader-10PROTAC BRD4 Degrader-10；PROTAC BRD4 Degrader-10
PROTAC BRD4 Degrader-10, also known as compound 8b, is a dual ligand-based PROTAC that combines ligands for von Hippel-Lindau and BRD4. To degrade the BRD4 protein in PC3 prostate cancer cells, PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies, with respective DC 50 values of 1.3 nM and 18 nM.
价 格：￥电议型 号：T40073产 地：中国大陆
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T40072PROTAC BRD4 Degrader-9；PROTAC BRD4 Degrader-9PROTAC BRD4 Degrader-9；PROTAC BRD4 Degrader-9
PROTAC BRD4 Degrader-9 (compound 8a) is a novel chemical compound consisting of ligands for von Hippel-Lindau and BRD4, connected by a PROTAC moiety. This compound can effectively degrade the BRD4 protein in PC3 prostate cancer cells. When conjugated with STEAP1 and CLL1 antibodies, PROTAC BRD4 Degrader-9 exhibits potent activity, with respective DC50 values of 0.86 nM and 7.6 nM.
价 格：￥电议型 号：T40072产 地：中国大陆
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T39996PROTAC CDK9 degrader-4；PROTAC CDK9 degrader-4PROTAC CDK9 degrader-4；PROTAC CDK9 degrader-4
PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9, thereby modulating transcriptional activity.
价 格：￥电议型 号：T39996产 地：中国大陆
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T39920PROTAC IRAK4 degrader-3；PROTAC IRAK4 degrader-3PROTAC IRAK4 degrader-3；PROTAC IRAK4 degrader-3
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.
价 格：￥电议型 号：T39920产 地：中国大陆
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T39903PROTAC IRAK4 degrader-6；PROTAC IRAK4 degrader-6PROTAC IRAK4 degrader-6；PROTAC IRAK4 degrader-6
PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
价 格：￥电议型 号：T39903产 地：中国大陆
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T39902PROTAC IRAK4 degrader-5；PROTAC IRAK4 degrader-5PROTAC IRAK4 degrader-5；PROTAC IRAK4 degrader-5
PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader.
价 格：￥电议型 号：T39902产 地：中国大陆
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T39901PROTAC IRAK4 degrader-4；PROTAC IRAK4 degrader-4PROTAC IRAK4 degrader-4；PROTAC IRAK4 degrader-4
PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
价 格：￥电议型 号：T39901产 地：中国大陆
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T39837PROTAC ERRα Degrader-3；PROTAC ERRα Degrader-3PROTAC ERRα Degrader-3
PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein. At a concentration of 30 nM, this compound exhibits a remarkable degradation capability, reducing the ERRα protein levels by >80%. Importantly, PROTAC ERRα Degrader-3 shows no activity against the ERRβ and ERRγ proteins.
价 格：￥电议型 号：T39837产 地：中国大陆
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T39727ERα degrader-2；ERα降解剂2ERα degrader-2
ERα degrader-2 is a selective and potent estrogen receptor (SERD) degrader with anticancer activity, inhibits ERα, and has an EC50 value for estrogen receptor degradation of 0.3 nM.ERα degrader-2 can be used for the prevention and treatment of HER-positive breast cancer.
价 格：￥电议型 号：T39727产 地：中国大陆
