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T74602PROTAC EZH2 Degrader-1；化合物 PROTAC EZH2 Degrader-1PROTAC EZH2 Degrader-1
PROTAC EZH2 Degrader-1 (Compound 150d), a potent inhibitor, effectively suppresses EZH2 methyltransferase activity, demonstrating an IC50 of 2.7 nM. EZH2 is crucial in various tumorigenesis and development processes [1].
价 格：￥电议型 号：T74602产 地：中国大陆
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T74557α1A-AR Degrader 9c；化合物 α1A-AR Degrader 9cα1A-AR Degrader 9c
α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC50 of 2.86 μM. It promotes the proteasomal degradation of the α1A-AR and exhibits anti-proliferative effects against PC-3 cells, presenting an IC50 value of 6.12 μM. This compound demonstrates antitumor activity and holds potential for prostate cancer research [1].
价 格：￥电议型 号：T74557产 地：中国大陆
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T74545STAT3 degrader-1；化合物 STAT3 degrader-1STAT3 degrader-1
STAT3 Degrader-1 (Compound 295) is a potent degrader of STAT3, utilized in anticancer research [1].
价 格：￥电议型 号：T74545产 地：中国大陆
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T74525PROTAC EGFR degrader 6；化合物 PROTAC EGFR degrader 6PROTAC EGFR degrader 6
PROTAC EGFR degrader 6 is a potent PROTAC EGFR degrader that effectively reduces EGFR Del19 levels in HCC827 cells, exhibiting a DC50 of 45.2 nM. It notably promotes apoptosis and induces G1 phase arrest in HCC827 cells [1].
价 格：￥电议型 号：T74525产 地：中国大陆
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T74524PROTAC EGFR degrader 5；化合物 PROTAC EGFR degrader 5PROTAC EGFR degrader 5
PROTAC EGFR Degrader 5 (Compound 10), a potent degrader of EGFR Del19 in HCC827 cells, achieves this with a DC50 of 34.8 nM. This compound effectively induces apoptosis in HCC827 cells and causes cell cycle arrest in the G1 phase [1].
价 格：￥电议型 号：T74524产 地：中国大陆
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T74519PROTAC CYP1B1 degrader-1；化合物 PROTAC CYP1B1 degrader-1PROTAC CYP1B1 degrader-1
PROTAC CYP1B1 Degrader-1 (Compound 6C), an α-naphthoflavone chimera derivative, effectively targets and degrades cytochrome P450 (CYP) 1B1 to overcome agent resistance, displaying half-maximal inhibitory concentrations (IC50s) of 95.1 nM for CYP1B1 and 9838.6 nM for CYP1A2. This compound is suitable for investigating prostate cancer characterized by overexpression of CYP1B1 [1].
价 格：￥电议型 号：T74519产 地：中国大陆
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T74518PROTAC VEGFR-2 degrader-2；化合物 PROTAC VEGFR-2 degrader-2PROTAC VEGFR-2 degrader-2
PROTAC VEGFR-2 degrader-2 (PROTAC-4), a specific degrader of VEGFR-2, demonstrates minimal inhibition of VEGFR-2 (IC50 > 1 μM) and low anti-proliferative activity towards EA.hy926 cells (IC50 > 100 μM) [1].
价 格：￥电议型 号：T74518产 地：中国大陆
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T74517PROTAC VEGFR-2 degrader-1；化合物 PROTAC VEGFR-2 degrader-1PROTAC VEGFR-2 degrader-1
PROTAC VEGFR-2 Degrader-1 (PROTAC-1), a specific degrader of PROTAC VEGFR-2, demonstrates minimal inhibition of VEGFR-2 (IC50 > 1 μM) and exhibits low anti-proliferative effects on EA.hy926 cells (IC50 > 100 μM) [1].
价 格：￥电议型 号：T74517产 地：中国大陆
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T74515PROTAC EGFR degrader 4；化合物 PROTAC EGFR degrader 4PROTAC EGFR degrader 4
PROTAC EGFR degrader 4 is a potent molecule designed to target and degrade mutant EGFR, showcasing its effectiveness by inducing degradation of EGFR del19 and EGFR L858R/T790M with DC50 values of 0.51 nM and 126 nM, respectively. Furthermore, it significantly inhibits the growth of HCC827 and H1975 cell lines, demonstrating IC50 values of 0.83 nM and 203.1 nM, respectively. The induced degradation of EGFR by this compound is associated with autophagy [1].
价 格：￥电议型 号：T74515产 地：中国大陆
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T74512PROTAC eEF2K degrader-1；化合物 PROTAC eEF2K degrader-1PROTAC eEF2K degrader-1
PROTAC eEF2K degrader-1 (Compound 11l), an eEF2K-targeting PROTAC small molecule, effectively induces apoptosis in MDA-MB-231 cells through mediating eEF2K degradation [1].
价 格：￥电议型 号：T74512产 地：中国大陆
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T74439PROTAC SOS1 degrader-1；化合物 PROTAC SOS1 degrader-1PROTAC SOS1 degrader-1
PROTAC SOS1 degrader-1, a potent compound, demonstrates an effective degradation of PROTAC SOS1 with a DC50 value of 98.4 nM. It exhibits antiproliferative activity against cancer cells harboring diverse KRAS mutations and has shown an antitumor effect with low toxicity [1].
价 格：￥电议型 号：T74439产 地：中国大陆
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T74430SHP2 protein degrader-2；化合物 SHP2 protein degrader-2SHP2 protein degrader-2
SHP2 protein degrader-2 (SHP2-D26), a PROTAC degrader targeting the SHP2 protein, effectively diminishes its expression levels across various cancer cell types [1].
价 格：￥电议型 号：T74430产 地：中国大陆
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T74410PROTAC AR-V7 degrader-1；化合物 PROTAC AR-V7 degrader-1PROTAC AR-V7 degrader-1
PROTAC AR-V7 degrader-1 (Compound 6) is an orally bioavailable, potent, and selective degrader targeting the androgen receptor (AR) variant V7, achieving degradation with a DC50 of 0.32 ?M by directing the VHL E3 ligase to the AR DNA-binding domain (DBD). It demonstrates efficacy in the 22Rv1 cell line expressing AR-V7, with an EC50 of 0.88 ?M [1].
价 格：￥电议型 号：T74410产 地：中国大陆
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T74376PROTAC ER Degrader-10；化合物 PROTAC ER Degrader-10PROTAC ER Degrader-10
PROTAC ER Degrader-10 is a potent PROTAC ER degrader and can be used for cancer research.
价 格：￥电议型 号：T74376产 地：中国大陆
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T74375PROTAC ERα Y537S degrader-1；化合物 PROTAC ERα Y537S degrader-1PROTAC ERα Y537S degrader-1
PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader [1] .
价 格：￥电议型 号：T74375产 地：中国大陆
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T74356PROTAC SOS1 degrader-2；化合物 PROTAC SOS1 degrader-2PROTAC SOS1 degrader-2
PROTAC SOS1 degrader-2, a potent degrader of PROTAC SOS1, effectively reduces the expression of pERK and RAS-GTP in a dose-dependent manner. It significantly inhibits tumor growth in vivo [1].
价 格：￥电议型 号：T74356产 地：中国大陆
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T74354PROTAC Axl Degrader 2；化合物 PROTAC Axl Degrader 2PROTAC Axl Degrader 2
PROTAC Axl Degrader 2, a potent and selective PROTAC Axl degrader, demonstrates an IC50 of 1.61 ?M. It exhibits anti-proliferative and anti-migratory activities in vitro and induces mehuosis [1].
价 格：￥电议型 号：T74354产 地：中国大陆
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T74353PROTAC Axl Degrader 1；化合物 PROTAC Axl Degrader 1PROTAC Axl Degrader 1
PROTAC Axl Degrader 1 is a potent, selective degrader of PROTAC Axl, exhibiting an IC50 of 0.92 ?M. It demonstrates in vitro anti-proliferative and anti-migratory activities and induces mehuosis [1].
价 格：￥电议型 号：T74353产 地：中国大陆
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T74351PROTAC EGFR degrader 3；化合物 PROTAC EGFR degrader 3PROTAC EGFR degrader 3
PROTAC EGFR Degrader 3, a highly potent molecule, exhibits remarkable cellular activity against H1975 and HCC827 cells, maintaining high selectivity. It additionally reveals the lysosome´s crucial role in the degradation mechanism of mutant EGFR [1].
价 格：￥电议型 号：T74351产 地：中国大陆
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T74333PROTAC EGFR degrader 2；化合物 PROTAC EGFR degrader 2PROTAC EGFR degrader 2
PROTAC EGFR degrader 2 is a potent compound with exceptional antiproliferative activity, evidenced by its IC50 of 4.0 nM, and exhibits strong EGFR degradation activity with a DC50 of 36.51 nM. It is suitable for synthesizing nitroreductase (NTR)-responsive PROTACs [1].
价 格：￥电议型 号：T74333产 地：中国大陆
