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T70098CDK8-IN-18;化合物 CDK8-IN-18CDK8-IN-18
CDK8-IN-18, also known as ZINC584617986, is a potent and selective inhibitor of CDK8, also modulating CDK19.
价 格:¥电议型 号:T70098产 地:中国大陆
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T70095Mps1-IN-1 dihydrochloride;化合物 Mps1-IN-1 dihydrochlorideMps1-IN-1 dihydrochloride
Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM. It effectively inhibits the activity of Mps1 mitotic kinase and disrupts spindle assembly checkpoint (SAC) function, thereby reducing the viability of both cancerous and ´normal´ cells.
价 格:¥电议型 号:T70095产 地:中国大陆
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T70064PDE1-IN-1;化合物 PDE1-IN-1PDE1-IN-1
PDE1-IN-1can enhance levels of the second messengers cAMP/cGMP leading to the expression of neuronal plasticity-related genes, neurotrophic factors, and neuroprotective molecules. These neuronal plasticity enhancement properties make PDE1 inhibitors good candidates as therapeutic agents in many neurological conditions.
价 格:¥电议型 号:T70064产 地:中国大陆
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T69917EphB1-IN-10;化合物 EphB1-IN-10EphB1-IN-10
EphB1-IN-10 is a potent and selective covalent inhibitor of receptor tyrosine kinase EphB1.
价 格:¥电议型 号:T69917产 地:中国大陆
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T69894MAP3K14-IN-173;化合物 MAP3K14-IN-173MAP3K14-IN-173
MAP3K14-IN-173 is a potent MAP3K14 kinase inhibitor.
价 格:¥电议型 号:T69894产 地:中国大陆
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T68378PRMT4-IN-1;化合物 PRMT4-IN-1PRMT4-IN-1
PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].
价 格:¥电议型 号:T68378产 地:中国大陆
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T68343PyrD-IN-14;化合物 PyrD-IN-14PyrD-IN-14
PyrD-IN-14 is an inhibitor of the PyrD protein (a dihydroorotate dehydrogenase (DHODase) involved in pyrimidine biosynthesis) which suppresses bacterial cytotoxicity, biofilm formation, and antibiotic resistance.
价 格:¥电议型 号:T68343产 地:中国大陆
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T67939Tyrosinase-IN-16;化合物 Tyrosinase-IN-16Tyrosinase-IN-16
Tyrosinase-IN-16 inhibited tyrosinase.
价 格:¥电议型 号:T67939产 地:中国大陆
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T67919NMT-IN-1;化合物NMT-IN-1NMT-IN-1
NMT-IN-1 is a potent inhibitor of N-nutyltransferase (NMT), with IC50 of 31μM for TbNMT and 66μM for hNMT. NMT-IN-1 is a potential compound for the treatment of African trypanosomiasis.
价 格:¥电议型 号:T67919产 地:中国大陆
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T67912PA3552-IN-1;化合物 PA3552-IN-1PA3552-IN-1|||PA3552IN1;PA3552-IN-1|||PA3552IN1
PA3552-IN-1 is an antibiotic adjuvant that can reduce the expression of PA3552 and restore the sensitivity of MDR Pseudomonas aeruginosa DK2 strain to Polymyxin B.
价 格:¥电议型 号:T67912产 地:中国大陆
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T67901SRD5A1-IN-1;化合物SRD5A1-IN-1SRD5A1-IN-1
SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 ?M). SRD5A1-IN-1 lowers the production of dihydrotestosterone and shows a significant decrease in the SRD5A1 protein expression.
价 格:¥电议型 号:T67901产 地:中国大陆
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T67883EZH2-IN-15;化合物 EZH2-IN-15SHR2554;SHR2554
EZH2-IN-15 is a specific inhibitor of histone modifier enhancer of zeste 2 (EZH2). EZH2 is aberrantly overexpressed in a number of human cancers that controls the adaptive response via regulation of Treg activity. Intratumoral EZH2 expression has also been shown to control the innate immunity
价 格:¥电议型 号:T67883产 地:中国大陆
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T67783trans-isrib A17;化合物ISR-IN-1ISR-IN-1;ISR-IN-1
trans-isrib A17 (ISR-IN-1) is an potent inhibitor of the integrated stress response with EC50 of 0.6 nM.
价 格:¥电议型 号:T67783产 地:中国大陆
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T67780AM5992;化合物AM5992CDK4/6-IN-16;CDK4/6-IN-16
AM5992 (example 195) is a potent CDK4 and CDK6 inhibitor (CDK4, IC50= 0.013 μM). AM5992 can be used for the research of CDK4-mediated disorders.
价 格:¥电议型 号:T67780产 地:中国大陆
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T67776PCSK9-IN-11;化合物PCSK9-IN-11PCSK9-IN-11
PCSK9-IN-11 (compound 5r) is a potent PCSK9 inhibitor with oral activity. PCSK9-IN-11 shows inhibitory activity of PCSK9 transcription in HepG2 cells (IC50= 5.7 μM). PCSK9-IN-11 can increase LDL receptor (LDLR) protein level. PCSK9-IN-11 can be used for atherosclerosis research.
价 格:¥电议型 号:T67776产 地:中国大陆
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T67775Enpp/Carbonic anhydrase-IN-1;Enpp/Carbonic脱水酶-IN-1Enpp/Carbonic anhydrase-IN-1
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 ?M for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 exhibits selective antiproliferative activity for cancer cells.
价 格:¥电议型 号:T67775产 地:中国大陆
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T67754JAK3-IN-14;化合物 JAK3-IN-14JAK3-IN-14
JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ?40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.
价 格:¥电议型 号:T67754产 地:中国大陆
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T64362AZD0780;化合物AZD0780PCSK9-IN-12|||EX-A6975;PCSK9-IN-12|||EX-A6975
AZD0780 (EX-A6975) exhibits bind affinity for PCSK9 ( Kd <200 nM). AZD0780 has research value in cholesterol metabolism.
价 格:¥电议型 号:T64362产 地:中国大陆
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T64354Cystathionine-γ-lyase-IN-1;化合物Cystathionine-γ-lyase-IN-1SHIP-2a;SHIP-2a
Cystathionine-γ-lyase-IN-1 (SHIP-2a) is a selective inhibitor of cystathionine γ-lyase (CSE) enzyme (IC50= 6.3 μM).
价 格:¥电议型 号:T64354产 地:中国大陆
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T64321Octyl-beta-D-glucopyranoside;辛基-beta-D-吡喃葡萄糖苷Octyl glucoside|||11β-HSD1-IN-11;Octyl glucoside|||11β-
Octyl-beta-D-glucopyranoside (11β-HSD1-IN-11) is a non-ionic detergent, it can be widely used in the research of biotechnical, biochemical applications, solubilization and crystallization of membrane proteins.
价 格:¥电议型 号:T64321产 地:中国大陆