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  • T7281411β-HSD1-IN-12；11β-HSD1抑制剂1211β-HSD1-IN-12

    11β-HSD1-IN-12 is an 11β-HSD1 inhibitor.11β-HSD1-IN-12 is implicated in the conversion of glucocorticoids in vivo and can be used to study metabolic syndrome and obesity.

    价 格：￥电议型 号：T72814产 地：中国大陆

  • T72808(R)-TTBK1-IN-1；化合物 (R)-TTBK1-IN-1(R)-TTBK1-IN-1

    (R)-TTBK1-IN-1 is a potent, selective, and brain-penetrant inhibitor of tau tubulin kinase 1 (TTBK1), serving as an enantiomer of TTBK1-IN-1. It finds application in the research of Alzheimer’s disease and related tauopathies [1].

    价 格：￥电议型 号：T72808产 地：中国大陆

  • T72788EGFR/C797S-IN-1；化合物 EGFR/C797S-IN-1EGFR/C797S-IN-1

    EGFR/C797S-IN-1 is a potent inhibitor targeting the EGFR-C797S mutation, demonstrated by its IC 50 value of 0.128 ?M. This compound exhibits significant anti-proliferative and anti-tumor effects by inhibiting p-EGFR expression in a dose-dependent manner.

    价 格：￥电议型 号：T72788产 地：中国大陆

  • T72784LOTUB1/USP8-IN-1 HCl；OTUB1/USP8抑制剂1盐酸盐OTUB1/USP8-IN-1 HCl（2858800-98-1 Free base）；OTUB1/USP8-IN-1 HCl

    OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8. OTUB1/USP8-IN-1 may be used in the study of leukaemia.

    价 格：￥电议型 号：T72784L产 地：中国大陆

  • T72784OTUB1/USP8-IN-1；OTUB1/USP8 抑制剂1OTUB1/USP8-IN-1

    OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively.OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung cancer.

    价 格：￥电议型 号：T72784产 地：中国大陆

  • T72780HSP90/mTOR-IN-1；化合物 HSP90/mTOR-IN-1HSP90/mTOR-IN-1

    HSP90/mTOR-IN-1 is an effective and orally administrable inhibitor targeting both Hsp90 and mTOR, displaying IC50 values of 69 nM and 29 nM, respectively. This compound inhibits the proliferation of SW780 cells by overly activating the PI3K/AKT/mTOR pathway and induces apoptosis and autophagy through its selective inhibition of Hsp90 and mTOR. Additionally, HSP90/mTOR-IN-1 exhibits significant anti-tumor activity in vivo and is applicable in bladder cancer research.

    价 格：￥电议型 号：T72780产 地：中国大陆

  • T72763AChE/BuChE-IN-1；化合物 AChE/BuChE-IN-1AChE/BuChE-IN-1

    AChE/BuChE-IN-1, a selective butyrylcholinesterase (BuChE) inhibitor derived from chrysin, exhibits a potent efficacy with an IC50 of 0.48 μM against BuChE and a lesser inhibitory effect on acetylcholinesterase (AChE) with an IC50 of 7.16 μM. It demonstrates significant hydroxyl radical (·OH) scavenging activity, achieving an IC50 of 0.1674 μM, and effectively inhibits reactive oxygen species (ROS) and Aβ 1-42 aggregation, including self-aggregation, copper (Cu 2+)-induced, and AChE-induced aggr

    价 格：￥电议型 号：T72763产 地：中国大陆

  • T72754JAK2/STAT3-IN-1；化合物 JAK2/STAT3-IN-1JAK2/STAT3-IN-1

    JAK2/STAT3-IN-1 -10a) is a potent inhibitor of GP130, exhibiting an IC50 value of 3.04 ?M and demonstrating anti-tumor activity.

    价 格：￥电议型 号：T72754产 地：中国大陆

  • T72720Tyrosinase-IN-10；化合物 Tyrosinase-IN-10Tyrosinase-IN-10

    Tyrosinase-IN-10 serves as a partially competitive inhibitor of tyrosinase, demonstrating an inhibition concentration (IC50) value of 1.6 μM against the enzyme´s activity in lysates derived from human melanoma cells.

    价 格：￥电议型 号：T72720产 地：中国大陆

  • T72713PI3K/VEGFR2-IN-1；化合物 PI3K/VEGFR2-IN-1PI3K/VEGFR2-IN-1

    PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively. This compound also induces apoptosis and is utilized in cancer research [1].

    价 格：￥电议型 号：T72713产 地：中国大陆

  • T72706Keap1-Nrf2-IN-13；化合物 Keap1-Nrf2-IN-13Keap1-Nrf2-IN-13

    Keap1-Nrf2-IN-13 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI), exhibiting an IC50 value of 0.15 μM, indicative of its high efficacy. It binds strongly to the Keap1 protein by forming hydrogen bonds with critical polar residues (Asn414, Arg415, Arg483, Gln530), showcasing its specificity. This compound has implications for research into diseases associated with oxidative stress and inflammation, such as pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD)

    价 格：￥电议型 号：T72706产 地：中国大陆

  • T72703Tyrosinase-IN-11；化合物 Tyrosinase-IN-11Tyrosinase-IN-11

    Tyrosinase-IN-11, a potent inhibitor of tyrosinase, exhibits IC50 values of 50 nM and 64 nM for L-tyrosinase and L-dopa (L-dopa), respectively. It demonstrates significant antioxidant activity coupled with low cytotoxicity, highlighting its potential for research on skin hyperpigmentation.

    价 格：￥电议型 号：T72703产 地：中国大陆

  • T72699Cavα2δ1&NET-IN-1；化合物 Cavα2δ1&NET-IN-1Cavα2δ1&NET-IN-1

    Cavα2δ1&NET-IN-1 . Cavα2δ1&NET-IN-1 inhibits Ca v α2δ-1 with a K i of 112 nM. Cavα2δ1&NET-IN-1 inhibits NET with a K i of 383 nM and IC 50 of 67 nM. Cavα2δ1&NET-IN-1 can be used for research of pain [1] .

    价 格：￥电议型 号：T72699产 地：中国大陆

  • T72687Keap1-Nrf2-IN-11；化合物 Keap1-Nrf2-IN-11Keap1-Nrf2-IN-11

    Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression of tumor necrosis factor-alpha (TNF-α). By promoting Nrf2 nuclear translocation, it mitigates inflammation and is utilized in anti-inflammatory studies [1].

    价 格：￥电议型 号：T72687产 地：中国大陆

  • T72683PRRSV/CD163-IN-1；化合物 PRRSV/CD163-IN-1PRRSV/CD163-IN-1

    PRRSV/CD163-IN-1, a PRRSV/CD163 inhibitor, effectively blocks the interaction between the PRRSV glycoproteins (GP2a or GP4) and the CD163-SRCR5 domain, making it a valuable tool for porcine reproductive and respiratory syndrome (PRRS) research.

    价 格：￥电议型 号：T72683产 地：中国大陆

  • T72676Tubulin/MMP-IN-1；化合物 Tubulin/MMP-IN-1Tubulin/MMP-IN-1

    Tubulin/MMP-IN-1, a potent inhibitor of both tubulin and MMP, holds promise for cancer research. It effectively suppresses tubulin polymerization, induces G2/M phase cell cycle arrest, and promotes reactive oxidative stress (ROS) generation in HepG2 cells, ultimately triggering apoptosis via the mitochondrial-dependent apoptotic pathway.

    价 格：￥电议型 号：T72676产 地：中国大陆

  • T72671SARS-CoV-2-IN-12；化合物 SARS-CoV-2-IN-12SARS-CoV-2-IN-12

    SARS-CoV-2-IN-12, a potent inhibitor of the SARS-CoV-2-related 3C-like protease (K_i=32.1 pM), plays a crucial role in preventing SARS-CoV-2 viral replication, showcasing potential significance in COVID-19 research.

    价 格：￥电议型 号：T72671产 地：中国大陆

  • T72670PD-1/PD-L1-IN-13；PD-1/PD-L1-IN-13PD-1/PD-L1-IN-13

    PD-1/PD-L1-IN-13 is a potent immune checkpoint PD-1/PD-L1 inhibitor with an IC50 value of 10.2 nM for PD-1/PD- L1 interaction.PD-1/PD-L1-IN-13 promotes CD8+ T-cell activation and delays tumour growth in a Hepa1-6 homozygous mouse model.

    价 格：￥电议型 号：T72670产 地：中国大陆

  • T72607VEGFR-2/BRAF-IN-1；化合物 VEGFR-2/BRAF-IN-1VEGFR-2/BRAF-IN-1

    VEGFR-2/BRAF-IN-1, a dual inhibitor of VEGFR-2 and BRAF kinases, demonstrates potent inhibitory activity with IC50 values of 0.049 ?M for VEGFR-2, 0.063 ?M for BRAF V600E, and 0.005 ?M for BRAF WT. It effectively induces apoptosis and arrests the cell cycle primarily at the G1/S phase.

    价 格：￥电议型 号：T72607产 地：中国大陆

  • T72605C-RAF kinase-IN-1；化合物 C-RAF kinase-IN-1C-RAF kinase-IN-1

    C-RAF kinase-IN-1 is a potent inhibitor of C-RAF kinase with an IC 50 of 0.193 μM. C-RAF kinase-IN-1 is a quinoline derivative. C-RAF kinase-IN-1 has the potential for the research of cancer diseases [1] .

    价 格：￥电议型 号：T72605产 地：中国大陆

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