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T64274Neuraminidase-IN-11;化合物 Neuraminidase-IN-11Neuraminidase-IN-11
Neuraminidase-IN-11 (15e) is a selective and potent neuraminidase (NA) inhibitor that acts on the neuraminidase of H1N1 virus (IC50: 4.7 nM), H5N1 virus (IC50: 8.46 nM) and H5N8 virus (IC50: 1.5 nM).
价 格:¥电议型 号:T64274产 地:中国大陆
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T64273Nampt-IN-10 TFA;化合物 Nampt-IN-10 TFANampt-IN-10 TFA
Nampt-IN-10 TFA (compound 4) is a phosphoribosyltransferase (NAMPT) inhibitor with cellular efficacy against A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM). The Nampt-IN-10 TFA can be used as a non-antimitotic payload for ADCs.
价 格:¥电议型 号:T64273产 地:中国大陆
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T64247CREB-IN-1 TFA;化合物 CREB-IN-1 TFACREB-IN-1 TFA
CREB-IN-1 TFA is a potent, orally active CREB inhibitor with an IC50 value of 0.18 μM. CREB-IN-1 TFA exhibits inhibitory effects on the growth of breast cancer cells.
价 格:¥电议型 号:T64247产 地:中国大陆
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T64244CDK4/6-IN-10;化合物 CDK4/6-IN-10CDK4/6-IN-10
CDK4/6-IN-10 is a selective, potent, orally active inhibitor of CDK4 (IC50: 22 nM) and CDK6 (IC50: 10 nM) with antitumour effects. CDK4/6-IN-10 has potential for studies in multiple myeloma (MM).
价 格:¥电议型 号:T64244产 地:中国大陆
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T64229SENP2-IN-1;化合物 SENP2-IN-1SENP2-IN-1
SENP2-IN-1 is a selective inhibitor of SENP2. SENP2-IN-1 inhibits SENP1 (IC50: 1.3 μM), SENP2 (IC50: 0.69 μM) and SENP5 (IC50: 22.7 μM). SENP2-IN-1 can be used in cancer research.
价 格:¥电议型 号:T64229产 地:中国大陆
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T64218Keap1-Nrf2-IN-1 TFA;化合物 Keap1-Nrf2-IN-1 TFAKeap1-Nrf2-IN-1 TFA
Keap1-Nrf2-IN-1 TFA (compound35) is a Keap1-Nrf2 protein-protein interaction inhibitor (IC50: 43 nM) that activates Nrf2-regulated cytoprotective responses. Keap1-Nrf2-IN-1 TFA antagonizes acetaminophen-induced liver injury in cellular and in vivo models.
价 格:¥电议型 号:T64218产 地:中国大陆
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T64190Keap1-Nrf2-IN-12;化合物 Keap1-Nrf2-IN-12Keap1-Nrf2-IN-12
eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.
价 格:¥电议型 号:T64190产 地:中国大陆
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T64187HDAC1/6-IN-1;化合物 HDAC1/6-IN-1HDAC1/6-IN-1
HDAC1/6-IN-1 is a potent multi-target inhibitor of GLP (IC50: 1.3 nM), HDAC6 (IC50: 13 nM) and HDAC1 (IC50: 89 nM). HDAC1/6-IN-1 inhibits the methylation and deacetylation of H3K9 at the protein level. HDAC1/6-IN-1 can block the cell cycle of cancer cells in G0/G1 phase, induce apoptosis and prevent cancer cell migration and invasion.
价 格:¥电议型 号:T64187产 地:中国大陆
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T64186CARM1-IN-1 hydrochloride;化合物 CARM1-IN-1 hydrochlorideCARM1-IN-1 hydrochloride
CARM1-IN-1 hydrochloride is a potent and selective inhibitor of CARM1 (IC50: 8.6 μM) with low inhibition of PRMT1 and SET7.
价 格:¥电议型 号:T64186产 地:中国大陆
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T64185TAM&Met-IN-1;化合物 TAM&Met-IN-1TAM&Met-IN-1
TAM&Met-IN-1 is a potent inhibitor of TAM and c-Met, acting on AXL (IC50: 6.1 nM), MER (IC50: 13.2 nM) and TYRO3 (IC50: 21.6 nM). TAM&Met-IN-1 can be used in anticancer studies.
价 格:¥电议型 号:T64185产 地:中国大陆
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T64181sEH/AChE-IN-1;化合物 sEH/AChE-IN-1sEH/AChE-IN-1
sEH/AChE-IN-1 (Compound 12a) is a dual inhibitor of soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-1 has a cumulative effect against neuroinflammation and memory impairment. sEH/AChE-IN-1 has shown research potential in Alzheimer´s disease (AD).
价 格:¥电议型 号:T64181产 地:中国大陆
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T64172MraY-IN-1;化合物 MraY-IN-1MraY-IN-1
MraY-IN-1 (compound 12a) is a potent inhibitor (IC50: 140 μM) of the bacterial translocase MraY. MraY-IN-1 has antibacterial activity against Escherichia coli K12 (MIC50: 7 μg/ml), Bacillus subtilis W23 (MIC50: 12 μg/ml) and Pseudomonas fluorescens Pf-5 (MIC50: 46 μg/ml). /MraY-IN-1 can be used for antimicrobial studies.
价 格:¥电议型 号:T64172产 地:中国大陆
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T64170EGFR-IN-18;化合物 EGFR-IN-18EGFR-IN-18
EGFR-IN-18 is a potent inhibitor of the enzymatic activity of the L858R/T790M/C797S mutant EGFR (4.9 nM) and is also able to reduce the enzymatic activity of wild-type EGFR (47 nM).
价 格:¥电议型 号:T64170产 地:中国大陆
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T64156AChE/BChE-IN-1;化合物 AChE/BChE-IN-1AChE/BChE-IN-1
AChE/BChE-IN-1 is a potent dual inhibitor of acetylcholinesterase and butyrylcholinesterase with blood-brain barrier permeability, exhibiting an IC50 value of 1.06 and 7.3 nM for hAChE and hBChE, respectively, and showing antioxidant effects. AChE/BChE-IN-1 can be used in Alzheimer´s disease research.
价 格:¥电议型 号:T64156产 地:中国大陆
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T64154CYP51/HDAC-IN-1;化合物 CYP51/HDAC-IN-1CYP51/HDAC-IN-1
CYP51/HDAC-IN-1 is an orally active, potent, dual CYP51/HDAC inhibitor that inhibits important virulence factors and down-regulates the expression of associated drug resistance genes.CYP51/HDAC-IN-1 has shown effective therapeutic effects in both Candidiasis tropicalis and Cryptococcal meningitis.
价 格:¥电议型 号:T64154产 地:中国大陆
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T64145RORγt/DHODH-IN-1;化合物 RORγt/DHODH-IN-1RORγt/DHODH-IN-1
RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant in vivo anti-inflammatory effects.
价 格:¥电议型 号:T64145产 地:中国大陆
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T64143AChE/GSK-3β-IN-1;化合物 AChE/GSK-3β-IN-1AChE/GSK-3β-IN-1
AChE/GSK-3β-IN-1 is a potent dual AChE/GSK-3β inhibitor that crosses the blood-brain barrier and acts on hAChE (IC50: 1.2 nM), hBChE (IC50: 149.8 nM) and hGSK-3β (IC50: 22.4 nM). AChE/GSK-3β-IN-1 is able to occupy the ATP binding site of DYRK1A. aChE/GSK-3β-IN-1 exhibits high kinase selectivity for the CMGC kinase family. aChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. aChE/GSK-3β-IN-1 can be used to study Alzheimer´s disease.
价 格:¥电议型 号:T64143产 地:中国大陆
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T64138Cap-dependent endonuclease-IN-16;化合物 Cap-dependent endonuclease-IN-16Cap-dependent endonuclease-IN-1
Cap-dependent endonuclease-IN-16 is a pyridone polycyclic derivative and a potent inhibitor of cap-dependent nucleic acid endonucleases (CEN). cap-dependent endonuclease-IN-16 shows potential for influenza studies.
价 格:¥电议型 号:T64138产 地:中国大陆
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T64120SETDB1-TTD-IN-1 TFA;化合物 SETDB1-TTD-IN-1 TFASETDB1-TTD-IN-1 TFA
SETDB1-TTD-IN-1 TFA is a potent, selective, endogenous binding agent-competitive inhibitor of SETDB1-TTD (Kd: 88 nM).SETDB1-TTD-IN-1 TFA can be used to study SETDB1-TTD-associated biological functions and diseases.
价 格:¥电议型 号:T64120产 地:中国大陆
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T64107FGFR3-IN-1;化合物 FGFR3-IN-1FGFR3-IN-1
FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor that inhibits FGFR1 (IC50: 40 nM), FGFR2 (IC50: 5.1 nM) and FGFR3 (IC50: 12 nM).
价 格:¥电议型 号:T64107产 地:中国大陆