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T72604Multi-kinase-IN-1；化合物 Multi-kinase-IN-1Multi-kinase-IN-1
Multi-kinase-IN-1, a powerful kinase inhibitor, exhibits antitumor properties by inducing cell apoptosis. It is under investigation for its potential application in treating colorectal cancer.
价 格：￥电议型 号：T72604产 地：中国大陆
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T72574Axl/Mer/CSF1R-IN-1；化合物 Axl/Mer/CSF1R-IN-1Axl/Mer/CSF1R-IN-1
Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds) of less than 0.1 μM.
价 格：￥电议型 号：T72574产 地：中国大陆
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T72569Cathepsin L/S-IN-1；化合物 Cathepsin L/S-IN-1Cathepsin L/S-IN-1
Cathepsin L/S-IN-1, a dual inhibitor targeting Cathepsin L and Cathepsin S, exhibits potent and selective inhibition with IC50 values of 4.10 μM and 1.79 μM, respectively. Demonstrating significant antimetastatic and invasive effects, it effectively impacts pancreatic cancer BxPC-3 and PANC-1 cells.
价 格：￥电议型 号：T72569产 地：中国大陆
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T72553ARTD10/PARP10-IN-1；ARTD10/PARP10抑制剂1ARTD10/PARP10-IN-1
ARTD10/PARP10-IN-1 is a potent PARP inhibitor of the mono-ADP ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly ADP-ribose polymerase-1 (ARTD1/PARP1), with potential anticancer and antitumour activity for the study of prostate and breast cancers.
价 格：￥电议型 号：T72553产 地：中国大陆
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T72522Aurora kinase-IN-1；化合物 Aurora kinase-IN-1Aurora kinase-IN-1
Aurora kinase-IN-1, a potent aurora kinase inhibitor, modulates cell cycle progression and induces apoptosis by upregulating G1 cell cycle inhibitory proteins (including p21 and p27), elevating G1 progressive cyclin D1, and downregulating G1-to-S progressive cyclins, thereby arresting the cell cycle at the G1/S boundary. It stands as a promising lead compound for the development of chemotherapeutic agents.
价 格：￥电议型 号：T72522产 地：中国大陆
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T72505CTP Synthetase-IN-1；CTP Synthetase 抑制剂 1CTP Synthetase-IN-1
CTP Synthetase-IN-1 is an orally active and potent cytidine 5´-triphosphate synthetase (CTPS) inhibitor with potential antitumour activity, shows anti-inflammatory activity in animal models of inflammation, inhibits human CTPS1 and human CTPS2, and can be used in studies of arthritis and rheumatoid arthritis.
价 格：￥电议型 号：T72505产 地：中国大陆
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T72501CYP4A11/CYP4F2-IN-1；CYP4A11/CYP4F2 抑制剂 1CYP4A11/CYP4F2-IN-1
CYP4A11/CYP4F2-IN-1 is a cytochrome P450 (CYP) 4A11 and CYP4F2 inhibitor. CYP4A11/CYP4F2-IN-1 can be used to study kidney diseases and cardiovascular and cerebrovascular diseases.
价 格：￥电议型 号：T72501产 地：中国大陆
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T72437PARP1/2/TNKS1/2-IN-1；PARP1/2/TNKS1/2抑制剂1PARP1/2/TNKS1/2-IN-1
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis.
价 格：￥电议型 号：T72437产 地：中国大陆
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T72421LRRK2/NUAK1/TYK2-IN-1；化合物 LRRK2/NUAK1/TYK2-IN-1LRRK2/NUAK1/TYK2-IN-1
LRRK2/NUAK1/TYK2-IN-1 (compound 226) exhibits inhibitory activity against LRRK2 (Wt), LRRK2 (G2019), TYK2, and NUAK1, demonstrating IC50 values below 10 nM. This compound is useful for research into autoimmune diseases.
价 格：￥电议型 号：T72421产 地：中国大陆
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T72407c-Met/MEK1/Flt-3-IN-1；化合物 c-Met/MEK1/Flt-3-IN-1c-Met/MEK1/Flt-3-IN-1
Antiproliferative Against-3 (comp 33) demonstrates significant activity against Hela (IC 50 = 0.21 ?M), A549 (IC 50 = 0.39 ?M), and MCF-7 (IC 50 = 0.33 ?M) cell lines. Additionally, it induces apoptosis in a dose-dependent manner by arresting A549 cells in the G1 phase.
价 格：￥电议型 号：T72407产 地：中国大陆
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T72313SARS-CoV-2 3CLpro-IN-11；化合物 SARS-CoV-2 3CLpro-IN-11SARS-CoV-2 3CLpro-IN-11
SARS-CoV-2 3CLpro-IN-11(11d) is a broad-spectrum antiviral compound that effectively inhibits the SARS-CoV-2 3CL protease, achieving an IC50 of 140 nM. Additionally, it exhibits inhibitory activity against SARS-CoV-1 and MERS-CoV with IC50 values of 240 nM and 70 nM, respectively.
价 格：￥电议型 号：T72313产 地：中国大陆
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T72312SARS-CoV-2 3CLpro-IN-10；化合物 SARS-CoV-2 3CLpro-IN-10SARS-CoV-2 3CLpro-IN-10
SARS-CoV-2 3CLpro-IN-10(5d) is a potent inhibitor of the SARS-CoV-2 3CL protease, exhibiting an IC50 value of 190 nM, and demonstrates varied efficiency against other coronaviruses with IC50 values of 790 nM for SARS-CoV-1 and 70 nM for MERS-CoV, indicating broad-spectrum antiviral activity.
价 格：￥电议型 号：T72312产 地：中国大陆
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T72306Mycobacterial Zmp1-IN-1；化合物 Mycobacterial Zmp1-IN-1Mycobacterial Zmp1-IN-1
Mycobacterial Zmp1-IN-1, a zinc metalloprotease-1 (Zmp1) inhibitor, demonstrates dose-dependent anti-mycobacterial activity against Mtb H37Ra, making it suitable for tuberculosis (TB) research.
价 格：￥电议型 号：T72306产 地：中国大陆
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T72297Mtb-cyt-bd oxidase-IN-1；化合物 Mtb-cyt-bd oxidase-IN-1Mtb-cyt-bd oxidase-IN-1
Mtb-cyt-bd oxidase-IN-1 is a potent inhibitor of Mycobacterium tuberculosis cytochrome bd oxidase, possessing an inhibition constant (IC50) of 0.13 μM, making it valuable for tuberculosis research.
价 格：￥电议型 号：T72297产 地：中国大陆
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T72242DYRKs-IN-1 hydrochloride；化合物 DYRKs-IN-1 hydrochlorideDYRKs-IN-1 hydrochloride
DYRKs-IN-1 hydrochloride is a potent inhibitor of Dual-specificity tyrosine-phosphorylation-regulated kinases (DYRKs), exhibiting IC50 values of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. This compound demonstrates antitumor activity.
价 格：￥电议型 号：T72242产 地：中国大陆
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T72230SARS-CoV-2/MERS Mpro-IN-1；化合物 SARS-CoV-2/MERS Mpro-IN-1SARS-CoV-2/MERS Mpro-IN-1
SARS-CoV-2/MERS Mpro-IN-1 is a potent inhibitor of the main proteases in SARS-CoV-2 and MERS, exhibiting IC50 values of 0.10 and 0.06 ?M, respectively.
价 格：￥电议型 号：T72230产 地：中国大陆
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T72225Hsp90-IN-17 hydrochloride；化合物 Hsp90-IN-17 hydrochlorideHsp90-IN-17 hydrochloride
Hsp90-IN-17 (Example 5) hydrochloride, an HSP90 inhibitor, has potential applications in the research of proliferative conditions including cancer and neurodegenerative diseases.
价 格：￥电议型 号：T72225产 地：中国大陆
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T72180Acetyl-CoA Carboxylase-IN-1；化合物 Acetyl-CoA Carboxylase-IN-1Acetyl-CoA Carboxylase-IN-1
Acetyl-CoA Carboxylase-IN-1 is a potent inhibitor of acetyl-CoA carboxylase (ACC), exhibiting an inhibition concentration (IC50) of less than 5 nM. This compound also displays antibacterial activity.
价 格：￥电议型 号：T72180产 地：中国大陆
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T72117Cap-dependent endonuclease-IN-15；化合物 Cap-dependent endonuclease-IN-15Cap-dependent endonuclease-IN-1
Cap-dependent endonuclease-IN-15 is a potent inhibitor of cap-dependent endonuclease (CEN), effectively hindering the replication of influenza virus. This compound shows promise for the investigation of viral infections triggered by influenza viruses.
价 格：￥电议型 号：T72117产 地：中国大陆
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T72107Werner syndrome RecQ helicase-IN-1；Werner 综合征 RecQ 解旋酶-IN-1Werner syndrome RecQ helicase-IN-1
Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.
价 格：￥电议型 号：T72107产 地：中国大陆
