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  • T73025PARP7-IN-12；化合物 PARP7-IN-12PARP7-IN-12

    PARP7-IN-12, a potent inhibitor targeting PARP7, exhibits an IC50 of 7.836 nM. This compound is applicable in cancer research.

    价 格：￥电议型 号：T73025产 地：中国大陆

  • T73023PARP1-IN-12；化合物 PARP1-IN-12PARP1-IN-12

    PARP1-IN-12, a potent inhibitor of PARP1, demonstrates an IC50 value of 2.99 nM. It exhibits antiproliferative effects, induces apoptosis, and causes cell cycle arrest in the G2/M phase. Additionally, PARP1-IN-12 induces DNA double-strand breaks (DSBs) in BRCA-deficient cells.

    价 格：￥电议型 号：T73023产 地：中国大陆

  • T73022c-Met-IN-14；化合物 c-Met-IN-14c-Met-IN-14

    c-Met-IN-14, a N-sulfonylamidine-based derivative, is a selective c-Met kinase inhibitor with an IC50 value of 2.89 nM. It exhibits anticancer properties by inhibiting c-Met phosphorylation and arresting the cell cycle at the G2/M phase. Additionally, c-Met-IN-14 promotes dose-dependent apoptosis in A549 cells.

    价 格：￥电议型 号：T73022产 地：中国大陆

  • T73019MALT1-IN-11；化合物 MALT1-IN-11MALT1-IN-11

    MALT1-IN-11, a potent MALT1 protease inhibitor (IC 50 < 10 nM), effectively reduces IL10 secretion, exhibiting an IC 50 between 10-100 nM. This compound is primarily utilized in the study of cancer, autoimmune, and inflammatory disorders.

    价 格：￥电议型 号：T73019产 地：中国大陆

  • T73018NLRP3-IN-13；化合物 NLRP3-IN-13NLRP3-IN-13

    NLRP3-IN-13 is a selective and potent inhibitor of NLRP3 (IC 50: 2.1 μM), capable of inhibiting both NLRP3 and NLRC4 inflammasomes as well as NLRP3-mediated IL-1β production. Furthermore, NLRP3-IN-13 suppresses NLRP3 ATPase activity. This compound is utilized in research focused on neuroinflammatory disorders.

    价 格：￥电议型 号：T73018产 地：中国大陆

  • T73015NLRP3-IN-16；化合物 NLRP3-IN-16NLRP3-IN-16

    NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in inflammation research [1].

    价 格：￥电议型 号：T73015产 地：中国大陆

  • T73014NLRP3-IN-15；化合物 NLRP3-IN-15NLRP3-IN-15

    NLRP3-IN-15 is a potent, selective inhibitor of the NLRP3 inflammasome, demonstrating efficacy by inhibiting IL-1β (interleukin-1 beta) release with an IC50 value of 0.114 μM. This compound is utilized in the research of inflammation.

    价 格：￥电议型 号：T73014产 地：中国大陆

  • T73013NLRP3-IN-14；化合物 NLRP3-IN-14NLRP3-IN-14

    NLRP3-IN-14 is a potent, selective inhibitor of the NLRP3 inflammasome, displaying a dissociation constant (K D) of 5.87 μM and an IC50 of 0.131 μM for inhibiting IL-1β release. It is applicable for inflammation research.

    价 格：￥电议型 号：T73013产 地：中国大陆

  • T73008PCSK9-IN-13；化合物 PCSK9-IN-13PCSK9-IN-13

    PCSK9-IN-13 is a potent inhibitor of PCSK9, effectively preventing the binding of PCSK9 to low-density lipoprotein (LDL) receptors through its mechanism of action. It exhibits this inhibitory activity with an IC 50 value of 537 nM.

    价 格：￥电议型 号：T73008产 地：中国大陆

  • T73002METTL3-IN-1；化合物 METTL3-IN-1METTL3-IN-1

    METTL3-IN-1 is a polyheterocyclic compound, acts as METTL3 inhibitor [1] .

    价 格：￥电议型 号：T73002产 地：中国大陆

  • T73000SIRT2-IN-11；化合物 SIRT2-IN-11SIRT2-IN-11

    SIRT2-IN-11 (AEM1) is a selective inhibitor of SIRT2, demonstrating an inhibitory concentration (IC50) of 18.5 μM. It induces apoptosis in a p53-dependent manner and activates the expression of CDKN1A, PUMA, and NOXA, while also enhancing the acetylation of p53. This compound is utilized in the study of p53-associated cancers.

    价 格：￥电议型 号：T73000产 地：中国大陆

  • T72996Hsp90-IN-17；化合物 Hsp90-IN-17Hsp90-IN-17

    Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.

    价 格：￥电议型 号：T72996产 地：中国大陆

  • T72978c-Met-IN-16；化合物 c-Met-IN-16c-Met-IN-16

    c-Met-IN-16 is a c-Met inhibitor that can be used for cancer research [1] .

    价 格：￥电议型 号：T72978产 地：中国大陆

  • T7296THZ2；化合物THZ2CDK7-IN-1；CDK7-IN-1

    THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).

    价 格：￥电议型 号：T7296产 地：中国大陆

  • T72957DRAK1/2-IN-1；化合物 DRAK1/2-IN-1DRAK1/2-IN-1

    DRAK1/2-IN-1 is a potent inhibitor targeting both DRAK1 and DRAK2, displaying dissociation constants (Kd) of 1 ?M and 6 ?M, respectively.

    价 格：￥电议型 号：T72957产 地：中国大陆

  • T72951CDK4/6-IN-14；化合物 CDK4/6-IN-14CDK4/6-IN-14

    CDK4/6-IN-14 is a potent, highly selective inhibitor of Cyclin-Dependent Kinases 4 and 6 (CDK4/6), demonstrating inhibition concentrations (IC50s) of 10 nM and 16 nM, respectively. It possesses over 60-fold greater selectivity for CDK4/6 compared to CDKs 1, 2, 7, and 9, and exhibits significant selectivity against a panel of 205 other kinases.

    价 格：￥电议型 号：T72951产 地：中国大陆

  • T7295015-PGDH-IN-1；化合物 15-PGDH-IN-115-PGDH-IN-1

    15-PGDH-IN-1 is an orally active, potent inhibitor of 15-PGDH, exhibiting significant inhibitory activity against recombinant human 15-PGDH with an IC50 value of 3 nM. This compound is utilized in the research of tissue repair and regeneration.

    价 格：￥电议型 号：T72950产 地：中国大陆

  • T72948hDHODH-IN-11；化合物 hDHODH-IN-11hDHODH-IN-11

    hDHODH-IN-11, a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 value of 7.2 nM and has low cytotoxicity. It is applicable in acute myeloid leukemia (AML) research.

    价 格：￥电议型 号：T72948产 地：中国大陆

  • T72946G4/HDAC-IN-1；化合物 G4/HDAC-IN-1G4/HDAC-IN-1

    G4/HDAC-IN-1, a dual-targeting compound for G4 and HDAC, shows inhibition of intracellular HDAC activity, with an IC50 value of 1.1 μM, and promotes G4 formation. It effectively inhibits proliferation and tumor growth in a TNBC xenograft model, presenting potential for cancer research applications.

    价 格：￥电议型 号：T72946产 地：中国大陆

  • T72944eIF4A3-IN-18；化合物 eIF4A3-IN-18eIF4A3-IN-18

    eIF4A3-IN-18, a silvestrol analogue, disrupts the formation of the eIF4F translation complex, exhibiting EC 50 values of 0.8, 35, and 2 nM for myc-LUC, tub-LUC, and the growth inhibition of MBA-MB-231 cells, respectively. Additionally, it demonstrates cytotoxicity towards RMPI-8226 cells with an LC 50 of 0.06 nM. This compound is utilized in researching human cancer pathogenesis [1].

    价 格：￥电议型 号：T72944产 地：中国大陆

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