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T72064TASK-1-IN-1；化合物TASK-1-IN-1TASK-1-IN-1
TASK-1-IN-1 is a potent and selective inhibitor of TASK-1 (Potassium Channel) (IC50: 148 nM).TASK-1-IN-1 has a reduced inhibitory effect on the TASK-3 channel with an IC50 of 1750 nM.TASK-1-IN-1 has anticancer effects.
价 格：￥电议型 号：T72064产 地：中国大陆
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T72063PDCD4-IN-1；化合物PDCD4-IN-1PDCD4-IN-1
PDCD4-IN-1, a PDCD4 inhibitor (Kd : 350 nM), promotes BDNF expression in hippocampal neuronal cells HT-22.
价 格：￥电议型 号：T72063产 地：中国大陆
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T72060Myosin V-IN-1；化合物Myosin V-IN-1Myosin V-IN-1
Myosin V-IN-1 is a potent and selective inhibitor of Myosin V with a Ki value of 6 μM.Myosin V-IN-1 inhibits actin V and slows down actin-activated myosin V ATPase by selectively inhibiting the release of ADP from the actinoglobulin complex.
价 格：￥电议型 号：T72060产 地：中国大陆
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T72054SLC26A3-IN-1；化合物SLC26A3-IN-1SLC26A3-IN-1
SLC26A3-IN-1 is an inhibitor of the anion-exchange protein SLC26A3 with an IC50 value of 340 nM.SLC26A3 is a solute carrier (SLC) protein and a member of the SLC26 family, which has a wide range of anionic specificities for chloride, bicarbonate, sulfate, and oxalate.SLC26A3 is downregulated in adenomas (DRA) and is involved in the intestinal absorption of chloride and oxalate and is associated with chloride-losing diarrhea. SLC26A3 is downregulated in adenomas (DRA), is involved in the intestin
价 格：￥电议型 号：T72054产 地：中国大陆
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T72048CDK8-IN-12；化合物CDK8-IN-12CDK8-IN-12
CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showed anti-proliferative activity against MV4-11 cells.
价 格：￥电议型 号：T72048产 地：中国大陆
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T72029CDK8-IN-13；化合物CDK8-IN-13CDK8-IN-13
CDK8-IN-13 is a CDK8 inhibitor (IC50: 51.9 nM) with potent, selective and oral activity. CDK8-IN-13 induces apoptosis and reduces the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 exhibits anti-tumour activity.
价 格：￥电议型 号：T72029产 地：中国大陆
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T72026p53-MDM2-IN-1；化合物p53-MDM2-IN-1p53-MDM2-IN-1
p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 ?M. This compound holds potential for applications in anti-tumor research.
价 格：￥电议型 号：T72026产 地：中国大陆
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T72025PCSK9-IN-10；化合物PCSK9-IN-10PCSK9-IN-10
PCSK9-IN-10, a potent and orally active inhibitor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), exhibits a half-maximal inhibitory concentration (IC50) of 6.4 ?M. By enhancing the expression of Low-Density Lipoprotein Receptor (LDLR) protein and reducing PCSK9 expression, PCSK9-IN-10 effectively decreases atherosclerosis progression. This compound holds promise for hyperlipidemia research applications.
价 格：￥电议型 号：T72025产 地：中国大陆
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T71862GPR120-IN-1；化合物 GPR120-IN-1GPR120-IN-1
GPR120-IN-1 is a novel GPR120 inhibitor, showing ~90% inhibitory effects on cell growth with micromolar affinities against SW480.
价 格：￥电议型 号：T71862产 地：中国大陆
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T71747IKK?-IN-124；化合物 IKK?-IN-124IKK?-IN-124
IKK?-IN-124 is an allosteric inhibitor of IκBα phosphorylation and NF-κB transcriptional activity through selective capture of the inactive conformation and hence blockade of IKKβ S177/S181 phosphorylation.
价 格：￥电议型 号：T71747产 地：中国大陆
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T71739PTPMT1-IN-1；化合物 PTPMT1-IN-1PTPMT1-IN-1
PTPMT1-IN-1 is a PTEN-like mitochondrial phosphatase PTPMT1 inhibitor.
价 格：￥电议型 号：T71739产 地：中国大陆
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T71718Plk1 PBD-IN-143；化合物 Plk1 PBD-IN-143Plk1 PBD-IN-143
Plk1 PBD-IN-143 is a novel Inhibitor of the Polo-Box Domain of Polo-like Kinase 1 (Plk1 PBD).
价 格：￥电议型 号：T71718产 地：中国大陆
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T71558Pim-IN-14j；化合物 Pim-IN-14jPim-IN-14j
Pim-IN-14j is a potent, highly selective, and orally bioavailable inhibitor of PIM-1 kinases.
价 格：￥电议型 号：T71558产 地：中国大陆
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T70905TLR9-IN-18；化合物 TLR9-IN-18TLR9-IN-18
TLR9-IN-18 is a potent and selective TLR9 antagonist. TLR9-IN-18 suppresses the production of the proinflammatory cytokine IL-6 in a CpG-induced mouse model.
价 格：￥电议型 号：T70905产 地：中国大陆
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T7082HDAC8-IN-1；化合物HDAC8-IN-1HDAC8-IN-1
MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells[1].
价 格：￥电议型 号：T7082产 地：中国大陆
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T70650Caspase-6-IN-1；化合物 Caspase-6-IN-1Caspase-6-IN-1
Caspase-6-IN-1 is a novel Allosteric Inhibitor of Caspase-6 Activation, blocking the interaction between C6 and mHTT1-586.
价 格：￥电议型 号：T70650产 地：中国大陆
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T70604ClpB-IN-1；化合物ClpB-IN-1ClpB-IN-1
ClpB-IN-1 is a potential antimicrobial agent.ClpB-IN-1 is a potent ClpB inhibitor.
价 格：￥电议型 号：T70604产 地：中国大陆
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T70320GNLPT-IN-1；化合物 GNLPT-IN-1GNLPT-IN-1
GNLPT-IN-1 is an inhibitor of gram-negative lipoprotein trafficking.
价 格：￥电议型 号：T70320产 地：中国大陆
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T70202DDR1-IN-1 dihydrochloride；化合物 DDR1-IN-1 HClDDR1-IN-1 dihydrochloride
DDR1-IN-1 dihydrochloride is a selective and potent inhibitor of the DDR1 receptor tyrosine kinase, exhibiting an IC50 of 105 nM. It demonstrates fourfold reduced potency against DDR2, with an IC50 of 413 nM.
价 格：￥电议型 号：T70202产 地：中国大陆
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T7015Vps34-IN-1；化合物VPS34-IN1VPS34-IN1；VPS34-IN1
Vps34-IN-1 (VPS34-IN1) is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM in vitro, which does not significantly inhibit the isoforms of class I as well as class II PI3Ks.
价 格：￥电议型 号：T7015产 地：中国大陆
