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  • T61674COX-2/5-LOX-IN-1；化合物 COX-2/5-LOX-IN-1COX-2/5-LOX-IN-1

    COX-2/5-LOX-IN-1 (compound 3a), a benzothiophen-2-yl pyrazole carboxylic acid derivative, is a potent and dual inhibitor of COX-2 / 5-LOX. It exhibits superior analgesic and anti-inflammatory properties compared to Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 displays strong inhibitory activity against COX-1, COX-2, and 5-LOX, with IC50 values of 12.13 μM, 0.4 μM, and 4.96 μM, respectively [1].

    价 格：￥电议型 号：T61674产 地：中国大陆

  • T61658TYK2-IN-11；化合物 TYK2-IN-11TYK2-IN-11

    TYK2-IN-11 (Compound 5B) is a potent and selective inhibitor of Tyk-2, providing inhibition to TYK2-JH2 and JAK1-JH2 with IC50 values of 0.016 nM and 0.31 nM, respectively. This compound demonstrates potential for advancing research in the area of inflammatory and autoimmune diseases [1].

    价 格：￥电议型 号：T61658产 地：中国大陆

  • T61636ATR-IN-19；化合物 ATR-IN-19ATR-IN-19

    ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].

    价 格：￥电议型 号：T61636产 地：中国大陆

  • T61620AChE/PDE4-IN-1；化合物 AChE/PDE4-IN-1AChE/PDE4-IN-1

    AChE/PDE4-IN-1 (compound 12c) is a highly effective and specific dual inhibitor of PDE4 and AChE, with IC50 values of 0.28 μM and 1.88 μM for AChE and PDE4D, respectively. This compound demonstrates notable potential in reducing neuroinflammation associated with Alzheimer´s disease research [1].

    价 格：￥电议型 号：T61620产 地：中国大陆

  • T61613SARS-CoV-2-IN-17；化合物 SARS-CoV-2-IN-17SARS-CoV-2-IN-17

    SARS-CoV-2-IN-17 (Compound 16) is a highly effective inhibitor of SARS-CoV-2 nucleocapsid protein (NPro). It demonstrates potent anti-viral activity, with an EC50 value of 2.18 μM. Furthermore, SARS-CoV-2-IN-17 binds to NPro with a low Kd value of 7.82 μM, highlighting its potency as a NPro ligand [1].

    价 格：￥电议型 号：T61613产 地：中国大陆

  • T61605SK3 Channel-IN-1；化合物 SK3 Channel-IN-1SK3 Channel-IN-1

    SK3 Channel-IN-1 (compound 7a) is a powerful and selective modulator of the SK3 channel. It demonstrates significant efficacy in inhibiting breast cancer MDA-MB-435 cell migration while maintaining low cytotoxicity in other cell lines. Furthermore, SK3 Channel-IN-1 exhibits the ability to modulate ion channel activity in cancer cells [1].

    价 格：￥电议型 号：T61605产 地：中国大陆

  • T61600Tubulin polymerization-IN-10；化合物 Tubulin polymerization-IN-10Tubulin polymerization-IN-10

    Tubulin polymerization-IN-10 is a highly potent inhibitor of tubulin polymerization, exhibiting an IC50 value of 4.25±0.75 μM. It possesses significant anti-tumor properties [1].

    价 格：￥电议型 号：T61600产 地：中国大陆

  • T61596EGFR/HER2/DHFR-IN-1；化合物 EGFR/HER2/DHFR-IN-1EGFR/HER2/DHFR-IN-1

    EGFR/HER2/DHFR-IN-1 is a highly selective and potent anticancer compound specifically targeting MCF-7 breast cancer cells. It acts as a multi-inhibitor, targeting the EGFR/HER2 kinase and DHFR enzymes, with IC50 values of 0.153 μM, 0.108 μM, and 0.291 μM, respectively. Its mechanism of action involves cell cycle arrest at the G1/S phase and induction of apoptosis in cells [1].

    价 格：￥电议型 号：T61596产 地：中国大陆

  • T61589c-Fms-IN-13；化合物c-Fms-IN-13c-Fms-IN-13

    c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.

    价 格：￥电议型 号：T61589产 地：中国大陆

  • T61587ATR-IN-15；化合物 ATR-IN-15ATR-IN-15

    ATR-IN-15 (compound 1) is a highly potent and orally active inhibitor of ATR kinase with an IC50 of 8 nM. Additionally, ATR-IN-15 demonstrates inhibitory activity against several targets, including human colon tumor cells LoVo, DNA-PK, and PI3K, with IC50 values of 47, 663, and 5131 nM, respectively [1].

    价 格：￥电议型 号：T61587产 地：中国大陆

  • T61583CDK/HDAC-IN-1；化合物 CDK/HDAC-IN-1CDK/HDAC-IN-1

    CDK/HDAC-IN-1 exhibits potent inhibitory activity towards CDK2/4/6 and HDAC6, with IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM, respectively.

    价 格：￥电议型 号：T61583产 地：中国大陆

  • T61575USP15-IN-1；化合物USP15-IN-1USP15-IN-1

    USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM). USP15-IN-1 showed high antiproliferative activity against non-small cell lung cancer and leukemia cells. USP15 is an interacting protein of cGAS, and USP15 can promote cGAS to recognize DNA and activate downstream signaling pathways.

    价 格：￥电议型 号：T61575产 地：中国大陆

  • T61574PD-L1-IN-1；化合物 PD-L1-IN-1PD-L1-IN-1

    PD-L1-IN-1, a powerful PD-L1 inhibitor, demonstrated an IC50 of 115 nM. By forming a robust bond with the PD-L1 protein, PD-L1-IN-1 effectively suppressed tumor growth by enhancing the antitumor immune activity of peripheral blood mononuclear cells in co-cultures with PD-L1 expressing cancer cells (PC9 and HCC827 cells). It significantly elevated the release of interferon γ and induced apoptosis in cancer cells, while exhibiting minimal cytotoxicity in healthy cells [1].

    价 格：￥电议型 号：T61574产 地：中国大陆

  • T61569Mt KARI-IN-1；化合物 Mt KARI-IN-1Mt KARI-IN-1

    Mt KARI-IN-1 is a lead compound that demonstrates strong inhibitory activity towards Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), with a Ki value of 3.06 μM [1].

    价 格：￥电议型 号：T61569产 地：中国大陆

  • T61561VEGFR-2-IN-18；化合物 VEGFR-2-IN-18VEGFR-2-IN-18

    VEGFR-2-IN-18 (Compound 15d) is a high-potency inhibitor of VEGFR-2, with an IC 50 value of 60 nM. This compound effectively initiates cell apoptosis and demonstrates significant antitumor properties [1].

    价 格：￥电议型 号：T61561产 地：中国大陆

  • T61554CSF1R-IN-13；化合物 CSF1R-IN-13CSF1R-IN-13

    CSF1R-IN-13 is a powerful CSF1R inhibitor with potential applications in researching cancer diseases [1]. CSF1R, also known as colony stimulating factor 1 receptor, is a critical growth factor that regulates various cell types, including bone marrow progenitor cells, monocytes, macrophages, and giants [1]. CSF1R-IN-13 shows promise in furthering our understanding of cancer-related disorders (WO2019134661A1, compound 32) [1].

    价 格：￥电议型 号：T61554产 地：中国大陆

  • T61543CLK1/4-IN-1；化合物 CLK1/4-IN-1CLK1/4-IN-1

    CLK1/4-IN-1 (compound 31) is a highly potent and selective inhibitor of Clk1 and Clk4, with IC50 values of 9.7 nM and 6.6 nM, respectively. It effectively inhibits the growth of T24 cancer cells, with a GI50 value of 1.1 μM. CLK1/4-IN-1 has shown promising potential as an anticancer research tool [1].

    价 格：￥电议型 号：T61543产 地：中国大陆

  • T61542VEGFR-2-IN-17；化合物 VEGFR-2-IN-17VEGFR-2-IN-17

    VEGFR-2-IN-17 (Compound 15a) is a highly potent inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2), with an IC50 value of 67.25 nM. This compound exhibits significant antitumor properties [1].

    价 格：￥电议型 号：T61542产 地：中国大陆

  • T61537ASIC-IN-1；化合物 ASIC-IN-1ASIC-IN-1

    ASIC-IN-1 is a potent inhibitor of acid-sensing ion channels, demonstrating an IC 50 value of less than 10 μM. It effectively reduces pain intensity in a dose-dependent manner [1].

    价 格：￥电议型 号：T61537产 地：中国大陆

  • T61531NFATc1-IN-1；化合物NFATc1-IN-1NFATc1-IN-1

    NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuclear translocation of NFATc1. Due to its remarkable properties, NFATc1-IN-1 holds significant potential for advancing research related to osteoclastic diseases [1].

    价 格：￥电议型 号：T61531产 地：中国大陆

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