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  • T61435(S)-Cdc7-IN-18；化合物 (S)-Cdc7-IN-18(S)-Cdc7-IN-18

    (S)-Cdc7-IN-18, a potent CDC7 inhibitor, effectively impedes the overactivation of MCM2, a crucial tumor cell marker, induced by huCdc7 overexpression. Consequently, it inhibits the aberrant proliferation of tumor cells. This compound, exhibits promise for cancer disease research [1].

    价 格：￥电议型 号：T61435产 地：中国大陆

  • T61432ATR-IN-16；化合物 ATR-IN-16ATR-IN-16

    ATR-IN-16 (compound 46) is a highly effective ATR kinase inhibitor, exhibiting considerable anticancer activity in LoVo cells, as demonstrated by its IC 50 value of 410 nM [1].

    价 格：￥电议型 号：T61432产 地：中国大陆

  • T61423Transthyretin-IN-1；化合物 Transthyretin-IN-1Transthyretin-IN-1

    Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].

    价 格：￥电议型 号：T61423产 地：中国大陆

  • T61422DPP-4-IN-1；化合物 DPP-4-IN-1DPP-4-IN-1

    DPP-4-IN-1 (compound d1) is a highly potent inhibitor of DPP-4 (dipeptidyl peptidase 4) with an IC 50 of 49 nM, making it suitable for diabetes research [1]. It shares structural similarities to Alogliptin and can be effectively utilized for studying diabetes-related mechanisms.

    价 格：￥电议型 号：T61422产 地：中国大陆

  • T61415FLT3/ITD-IN-1；化合物 FLT3/ITD-IN-1FLT3/ITD-IN-1

    FLT3/ITD-IN-1 (Compound 1) is a highly potent inhibitor of FLT3 internal tandem duplications (FLT3-ITD). It exhibits remarkable inhibitory effects against FLT3 and FLT3-ITD, with impressive IC50 values of 38.2 nM and 144.1 nM, respectively. Moreover, FLT3/ITD-IN-1 shows exceptional antiproliferative activities against several acute myeloid leukemia cell lines [1].

    价 格：￥电议型 号：T61415产 地：中国大陆

  • T61407TRPC3/6-IN-1；化合物 TRPC3/6-IN-1TRPC3/6-IN-1

    TRPC3/6-IN-1 is a highly potent and selective inhibitor that specifically blocks the activity of the canonical transient receptor channels TRPC3 and TRPC6. It exhibits a significant blocking potency against the human isoforms hTRPC3 and hTRPC6, with IC50 values of 1260 nM and 500 nM, respectively. This compound, TRPC3/6-IN-1, is particularly valuable for conducting research on chronic models of heart failure [1].

    价 格：￥电议型 号：T61407产 地：中国大陆

  • T61405LSD1-IN-14；化合物 LSD1-IN-14LSD1-IN-14

    LSD1-IN-14, a powerful and specific inhibitor of LSD1 (with an IC50 value of 0.89 μM), effectively suppresses the growth of A549 and THP-1 cells and promotes the apoptosis of tumor cells [1].

    价 格：￥电议型 号：T61405产 地：中国大陆

  • T61392NLRP3-IN-10；化合物NLRP3-IN-10ZVN26391；ZVN26391

    NLRP3-IN-10 (ZVN26391) is a potent NLRP3 inhibitor. NLRP3-IN-10 inhibits IL-1β release with an IC50 value of 251.1 nM. NLRP3-IN-10 attenuates ASC speck formation, leading to suppress activation of NLRP3 inflammasome.

    价 格：￥电议型 号：T61392产 地：中国大陆

  • T61389TGFβ1-IN-1；TGFβ1 抑制剂1TGFβ1-IN-1

    TGFβ1-IN-1 is an orally active TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrotic markers (α-SMA and fibronectin) and can be used for the study of cancer and autoimmune diseases.

    价 格：￥电议型 号：T61389产 地：中国大陆

  • T61388hAChE/Aβ1-42-IN-1；化合物 hAChE/Aβ1-42-IN-1hAChE/Aβ1-42-IN-1

    Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and excellent brain-blood barrier (BBB) penetration with a broad safety margin. This compound shows promise for Alzheimer´s disease (AD) research [1].

    价 格：￥电议型 号：T61388产 地：中国大陆

  • T61385IDO1/TDO-IN-1；化合物 IDO1/TDO-IN-1IDO1/TDO-IN-1

    IDO1/TDO-IN-1 (30) is a highly effective inhibitor that targets both IDO1 and TDO enzymes with uncompetitive (Ki = 0.23 μM) and competitive (Ki = 0.73 μM) mechanisms, respectively. This compound, IDO1/TDO-IN-1 (30), exhibits a significant capacity to induce cell apoptosis via the potential mitochondria-mediated Bcl-2/Bax pathway [1].

    价 格：￥电议型 号：T61385产 地：中国大陆

  • T61377NTPDase-IN-1；化合物 NTPDase-IN-1NTPDase-IN-1

    NTPDase-IN-1 (compound 5a) is a selective inhibitor of NTPDase enzymes. It shows inhibitory activity against h-NTPDase-1, h-NTPDase-2, and h-NTPDase-8 with IC50 values of 0.05 μM, 0.23 μM, and 0.54 μM, respectively. NTPDase-IN-1 exerts non-competitive inhibition on h-NTPDase-1 and h-NTPDase-2, with a K m value of 21 μM for h-NTPDase-1. This compound is useful for investigating various conditions like cancer, immunologic disorders, and bacterial infections [1].

    价 格：￥电议型 号：T61377产 地：中国大陆

  • T61374Pantothenate kinase-IN-1；化合物 Pantothenate kinase-IN-1Pantothenate kinase-IN-1

    Pantothenate Kinase-IN-1 (Compound 1) functions as a modulator of Pantothenate Kinase (PANK), exhibiting an inhibition concentration (IC50) value of 0.51 μM against PANK3. It demonstrates notable ligand efficiency with a LipE value of 2.8 [1].

    价 格：￥电议型 号：T61374产 地：中国大陆

  • T61364LmCPB-IN-1；化合物 LmCPB-IN-1LmCPB-IN-1

    LmCPB-IN-1 (compound 35) is a highly effective and reversible covalent inhibitor of Leishmania mexicana cysteine protease B (LmCPB). It exhibits a strong binding affinity with a pK i value of 9.7 [1].

    价 格：￥电议型 号：T61364产 地：中国大陆

  • T61343RSV/IAV-IN-1；化合物 RSV/IAV-IN-1RSV/IAV-IN-1

    RSV/IAV-IN-1 (compound 14e) is a potent dual inhibitor of RSV/IAV with lower cytotoxicity compared to Ribavirin, suggesting promising potential for researching RSV and/or IAV infections [1].

    价 格：￥电议型 号：T61343产 地：中国大陆

  • T61342BChE-IN-13；化合物 BChE-IN-13BChE-IN-13

    BChE-IN-13 (Compound 17c) is an orally active, potent, and selective inhibitor of Butyrylcholinesterase (BChE). It exhibits IC50 values of 0.22 μM and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 demonstrates the capability to enhance memory and cognitive impairments, making it valuable for Alzheimer´s disease (AD) research [1].

    价 格：￥电议型 号：T61342产 地：中国大陆

  • T61339LDHA/PDKs-IN-1；化合物 LDHA/PDKs-IN-1LDHA/PDKs-IN-1

    LDHA/PDKs-IN-1 (compound 20e) is a highly effective dual inhibitor of PDKs and LDHA, displaying IC50 values of 0.8 μM and 0.15 μM, respectively. It significantly suppresses A549 cell proliferation (EC50 = 13.2 μM), reduces lactate formation, and enhances oxygen consumption. This compound holds great promise for cancer research [1].

    价 格：￥电议型 号：T61339产 地：中国大陆

  • T61333PDE11-IN-1；化合物 PDE11-IN-1PDE11-IN-1

    PDE11-IN-1 is a PDE11 inhibitor and can be used for adrenal insufficiency research [1].

    价 格：￥电议型 号：T61333产 地：中国大陆

  • T61326AIMP2-DX2-IN-1；AIMP2-DX2抑制剂1AIMP2-DX2-IN-1

    AIMP2-DX2-IN-1 is a potent AIMP2-DX2 inhibitor with potential antitumor activity for the study of lymphoma.

    价 格：￥电议型 号：T61326产 地：中国大陆

  • T61324BCR-ABL1-IN-1；化合物 BCR-ABL1-IN-1BCR-ABL1-IN-1

    BCR-ABL1-IN-1 is a highly potent and orally bioavailable inhibitor, displaying remarkable specificity towards ABL kinase. Notably, this compound holds significant promise for delineating the precise involvement of ABL kinases within the central nervous system, particularly in preclinical investigations [1].

    价 格：￥电议型 号：T61324产 地：中国大陆

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