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T61524Tubulin/HDAC-IN-1；化合物 Tubulin/HDAC-IN-1Tubulin/HDAC-IN-1
Tubulin/HDAC-IN-1 is a compound that functions as a dual inhibitor for tubulin and HDAC-IN-1. It achieves this by interacting with tubulin through CH/π interaction and with HDAC8 through hydrogen bond interaction. This compound effectively inhibits tubulin polymerization and selectively targets HDAC8 with an IC50 of 150 nM. Additionally, Tubulin/HDAC-IN-1 demonstrates cytotoxicity against various human cancer cells, induces cell cycle arrest in the G2/M phase, and triggers cell apoptosis. This c
价 格：￥电议型 号：T61524产 地：中国大陆
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T61519α-Glucosidase-IN-18；化合物 α-Glucosidase-IN-18α-Glucosidase-IN-18
α-Glucosidase-IN-18 (7B) is an orally active inhibitor of α-glucosidase, displaying an IC 50 value of 3.96 μM. This compound exhibits antidiabetic properties [1].
价 格：￥电议型 号：T61519产 地：中国大陆
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T61514Enpp-1-IN-12；化合物 Enpp-1-IN-12Enpp-1-IN-12
Enpp-1-IN-12 (compound 43), an orally active and potent inhibitor of ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) with a K i of 41 nM, exhibits anti-tumor activity [1].
价 格：￥电议型 号：T61514产 地：中国大陆
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T61510PIM-1/HDAC-IN-1；化合物 PIM-1/HDAC-IN-1PIM-1/HDAC-IN-1
PIM-1/HDAC-IN-1 (compound 4d) is a potent inhibitor of PIM-1, with an IC 50 of 343.87 nM. It also exhibits strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC 50 values of 63.65 and 62.39 nM, respectively. Furthermore, PIM-1/HDAC-IN-1 demonstrates apoptosis-inducing potential in MCF-7 cell lines, specifically inducing pre-G1 apoptosis and causing cell cycle arrest at the G2/M phase [1].
价 格：￥电议型 号：T61510产 地：中国大陆
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T61503α-Glucosidase-IN-15；化合物 α-Glucosidase-IN-15α-Glucosidase-IN-15
α-Glucosidase-IN-15 (Compound 14B) exhibits potent inhibitory activity against α-glucosidase, with an IC50 value of 3.34 μM. It possesses antidiabetic properties [1].
价 格：￥电议型 号：T61503产 地：中国大陆
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T61489VEGFR-2/DHFR-IN-1；化合物 VEGFR-2/DHFR-IN-1VEGFR-2/DHFR-IN-1
VEGFR-2/DHFR-IN-1 (compound 8b) is a chemical inhibitor targeting VEGFR-2 and DHFR, exhibiting IC50 values of 0.384 μM and 7.881 μM, respectively. It demonstrates effective antibacterial properties against a range of pathogens including Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA, and MRSA, with MIC values ranging from 8 to 16 μg/mL. Additionally, this compound shows potent cytotoxic effects against various cancer cell lines such as C26, HepG2, and MCF7, with IC50 values
价 格：￥电议型 号：T61489产 地：中国大陆
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T61487APE1-IN-1；APE1抑制剂1APE1-IN-1
APE1-IN-1 is a potent purine/pyrimidine endonuclease 1 (APE1)-free inhibitor that crosses the blood-brain barrier with potential antitumor activity and potentiates the cytotoxicity of the alkylating agent, methyl methanesulfonate, on cancer cells.
价 格：￥电议型 号：T61487产 地：中国大陆
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T61484LasR-IN-1；化合物 LasR-IN-1LasR-IN-1
LasR-IN-1 (compound 9g) is a highly effective inhibitor of LasR, exhibiting strong potency against E. coli. It also demonstrates significant anti-bacterial properties, displaying a minimum inhibitory concentration (MIC) of 28.13 μM against P. aeruginosa [1].
价 格：￥电议型 号：T61484产 地：中国大陆
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T61482Tubulin polymerization-IN-13；化合物 Tubulin polymerization-IN-13Tubulin polymerization-IN-13
Tubulin polymerization-IN-13 (Compound 4f) is a potent inhibitor of tubulin polymerization, with an IC50 value of 0.37 μM. It displays significant anti-proliferative effects against cancer cells, inducing apoptosis and exhibiting potential antivascular activity [1].
价 格：￥电议型 号：T61482产 地：中国大陆
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T61478ROS1-IN-1；化合物 ROS1-IN-1ROS1-IN-1
ROS1-IN-1 (Compound 31) is a highly effective and specific inhibitor of the ROS1 kinase, displaying a remarkable inhibitory concentration (IC 50) of 0.097 μM [1].
价 格：￥电议型 号：T61478产 地：中国大陆
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T61474HDAC6-IN-13；化合物 HDAC6-IN-13HDAC6-IN-13
HDAC6-IN-13 (Compound 35m) is a potent and highly selective orally active inhibitor of HDAC6, with an IC50 of 0.019 μM. It also demonstrates inhibitory activity against HDAC1, HDAC2, and HDAC3, with IC50 values of 1.53 μM, 2.06 μM, and 1.03 μM, respectively. HDAC6-IN-13 exhibits substantial blood-brain barrier permeability and displays anti-inflammatory properties [1].
价 格：￥电议型 号：T61474产 地：中国大陆
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T61463Monoamine oxidase/Aromatase-IN-1；化合物 Monoamine oxidase/Aromatase-IN-1Monoamine oxidase/Aromatase-IN-
Monoamine oxidase/Aromatase-IN-1 (compound 2q) is a potent dual inhibitor of monoamine oxidase (MAO) and aromatase, with IC50 values of 39 nM and 31 nM for MAO-B and aromatase, respectively. It holds significant potential for research in neurological disorders and breast cancer [1].
价 格：￥电议型 号：T61463产 地：中国大陆
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T61462EV-A71-IN-1；化合物 EV-A71-IN-1EV-A71-IN-1
EV-A71-IN-1 is a potent inhibitor of the human enterovirus A71 (EV-A71) capsid protein, with an EC50 of 0.27 μM against EV-A71. Acting as a capsid binder, EV-A71-IN-1 disrupts the crucial interaction between the viral VP1 protein and the host receptor hSCARB2. It displays broad-spectrum antiviral activity against various human enteroviruses, while being non-toxic to human cells (CC50 > 56.2 μM) [1].
价 格：￥电议型 号：T61462产 地：中国大陆
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T61451NMDAR/HDAC-IN-1；化合物 NMDAR/HDAC-IN-1NMDAR/HDAC-IN-1
NMDAR/HDAC-IN-1 (Compound 9d) is a potent dual inhibitor of N-methyl-D-aspartate receptors (NMDARs) and histone deacetylases (HDACs). It exhibits a high affinity (Ki = 0.59 μM) for NMDARs, while demonstrating significant inhibitory effects on various HDAC isoforms, including HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC 50 values of 2.67 μM, 8.00 μM, 2.21 μM, 0.18 μM, and 0.62 μM, respectively. Moreover, NMDAR/HDAC-IN-1 efficiently crosses the blood-brain barrier [1].
价 格：￥电议型 号：T61451产 地：中国大陆
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T61449HPK1-IN-18；化合物 HPK1-IN-18HPK1-IN-18
HPK1-IN-18 is a highly effective and specific HPK1 inhibitor. HPK1, a MAP kinase kinase kinase kinases (MAP4K) member, was initially isolated from hematopoietic progenitor cells. This compound, known as HPK1-IN-18, is valuable for investigating, preventing, or managing diseases or conditions linked to HPK1 activity, such as cancer[1].
价 格：￥电议型 号：T61449产 地：中国大陆
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T61448AZA1；化合物AZA1Rac1/Cdc42-IN-1；Rac1/Cdc42-IN-1
AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.
价 格：￥电议型 号：T61448产 地：中国大陆
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T61446BioA-IN-13；化合物 BioA-IN-13BioA-IN-13
BioA-IN-13 is a highly effective inhibitor of the Mycobacterium tuberculosis BioA enzyme, displaying potent cell permeability and whole-cell activity [1].
价 格：￥电议型 号：T61446产 地：中国大陆
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T61442HIF-1/2α-IN-1；化合物 HIF-1/2α-IN-1HIF-1/2α-IN-1
HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrease HIF-1α levels. This compound is particularly valuable for research on clear cell renal cell carcinoma (ccRCC) [1].
价 格：￥电议型 号：T61442产 地：中国大陆
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T61440TOPK-p38/JNK-IN-1；化合物 TOPK-p38/JNK-IN-1TOPK-p38/JNK-IN-1
TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NO production. It demonstrates anti-inflammatory properties by inhibiting downstream phosphorylation of related proteins and preventing the degradation of TOPK [1].
价 格：￥电议型 号：T61440产 地：中国大陆
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T61436Cdc7-IN-18；化合物 Cdc7-IN-18Cdc7-IN-18
Cdc7-IN-18 (compound 1-2) is a highly effective inhibitor of the CDC7 enzyme. It has an IC 50 value of 1.29 nM for the Cdc7/DBF4 enzyme. In addition, this compound exhibits strong antiproliferative activities, with an IC 50 value of 53.62 nM in COLO205 cells [1].
价 格：￥电议型 号：T61436产 地：中国大陆
